Top

International Orthopaedics

Published in:

01-11-2017 | Original Paper

The degree of cartilage degradation assessed by serum biomarker levels changes after arthroscopic knee synovectomy in rheumatoid arthritis patients

Authors: Marina Lipina, Maxim Makarov, Sergey Makarov, Alexander Novikov

Published in: International Orthopaedics | Issue 11/2017

Abstract

Purpose

In order to test the validity of the selected surgical technique as a way to manage persistent synovitis of the knee joint, as well as to slow down the cartilage and bone destruction, we studied the dynamics of biomarkers of inflammatory conditions, and bone and cartilage destruction after total arthroscopic synovectomy (TAS) of the knee joint.

Methods

The sampling comprised 124 RA patients (158 knees) who had undergone the TAS procedure between 2003 and 2015. Before surgery the rheumatoid factor (IgM), C-reactive protein (CRP), erythrocyte sedimentation rate test was completed for all patients. Blood serum samples were collected (prior to surgery, and three, six and 12 months after surgery) and frozen at −70°С. The content of CRP, Matrix metalloproteinase-3 (MMP-3), Cartilage Oligomeric Matrix Protein, as well as cross-linked Ctelopeptides of types I and II were measured in blood serum by means of polarization fluoroimmunoassay with the use of a standard set of reagents.

Results

The average duration of the disease in the studied group was 8.7 ± 6.6 years. Concentration of the inflammation markers showed that only MMP-3 displayed statistical significance.

Conclusions

The obtained results can be used as basis in assessing the efficiency and effectiveness of this method of treatment of persistent knee joint synovitis associated with the RA.

Åhlén M, Roshani L, Lidén M, Struglics A, Rostgård-Christensen L, Kartus J (2015) Inflammatory cytokines and biomarkers of cartilage metabolism 8 years after anterior cruciate ligament reconstruction: results from operated and contralateral knees. Am J Sports Med 43(6):1460–1466CrossRefPubMed

Arnett FC, Edworth SM, Bloch DA, et al (1988) The American rheumatism association 1987 revised criteria for the classification of rheumatoid arthritis. Arthritis Rheum 31(3):315-24. https://doi.org/10.1002/art.1780310302

Benucci M, Meacci F, Manfredi M, Gobbi FL, Infantino M, Ricci C, Sarzi-Puttini P, Atzeni F (2014) Can Tocilizumab decrease cartilage Oligomeric matrix protein levels and disease activity in patients with long-standing rheumatoid arthritis? Curr Rheumatol Rev 10(2):131–135CrossRefPubMed

Boers M, Brooks P, Simon LS et al (2005) OMERACT: an international initiative to improve outcome measurement in rheumatology. Clin Exp Rheumatol 23:10–13

Christgau S, Garnero P, Fledelius C, Moniz C et al (2001) Collagen type. II C-telopeptide fragments as an index of cartilage degradation Bone 29(3):209–215PubMed

Chu XQ, Wang JJ, Dou LD, Zhao G (2015) Cartilage oligomeric matrix protein and matrix metalloproteinase-3 expression in the serum and joint fluid of a reversible osteoarthritis rabbit model//. Genet Mol Res 14(4):14207–14215CrossRefPubMed

Crnkic M, Månsson B, Larsson L et al (2003) Serum cartilage oligomeric matrix protein (COMP) decreases in rheumatoid arthritis patients treated with infliximab or etanercept. Arthritis Res Ther 5(4):181–185CrossRef

El Defrawy AO, Gheita TA, Raslan HM, El Ansary MM, El Awar AH (2016) Serum and synovial cartilage oligomeric matrix protein levels in early and established rheumatoid arthritis. Z Rheumatol 75(9):917–923CrossRefPubMed

Fujikawa K, Kawakami A, Tamai M et al (2009) High serum cartilage oligomeric matrix protein determines the subset of patients with early-stage rheumatoid arthritis with high serum C-reactive protein, matrix metalloproteinase-3, and MRI-proven bone erosion J. Rheumatol 36(6):1126–1129. https://doi.org/10.3899/jrheum.080926

10.

Houseman M et al (2012) Baseline serum MMP-3 levels in patients with rheumatoid arthritis are still independently predictive of radiographic progression in a longitudinal observational cohort at 8 years follow up. Arthritis Res Ther 14(1):30. https://doi.org/10.1186/ar3734 CrossRef

11.

Gabay C, Kushner I (1999) Acute phase proteins and other systemic responses to inflammation. Engl J Med 340:448–454CrossRef

12.

Galil SM, El-Shafey AM, Hagrass HA, Fawzy F, Sammak AE (2016) Baseline serum level of matrix metalloproteinase-3 as a biomarker of progressive joint damage in rheumatoid arthritis patients. Int J Rheum Dis 19(4):377–384CrossRefPubMed

13.

Geiler G, Stiehl P (1974) Significance of the concepts basic activity and actual activity in the morphological evaluation of synovial membranes in rheumatoid arthritis. Z Rheumatol 33:73–86PubMed

14.

Karateev DE, Radenska-Lopovok SG, Nasonova VA, Ivanova MM (2003) Synovial membrane in the early stage of rheumatoid arthritis: clinico-morphological comparisons. Ter Arkh 75(5):12–20PubMed

15.

Karmakar S, Kay J, Gravallese EM (2010) Bone damage in rheumatoid arthritis: mechanistic insights and approaches to prevention. Rheum Dis Clin N Am 2:385–404CrossRef

16.

Larsen A, Dale K, Eek M (1977) Radiographic evaluation of rheumatoid arthritis and related conditions by standard reference films. Acta Radiol Diag 18(4):481–491

17.

Lohmander LS, Atley LM, Pietka TA, Eyre DR (2003) The release of crosslinked peptides from type II collagen into human synovial fluid is increased soon after joint injury and in osteoarthritis. Arthritis Rheum 11:3130–3139CrossRef

18.

Outerbridge RE (1961) The etiology of chondromalacia patellae. J Bone Joint Surg Br 43:752–757PubMed

19.

Reijman M, Hazes JM, Bierma-Zeinstra SM et al (2004) A new marker for osteoarthritis: cross-sectional and longitudinal approach. Arthritis Rheum 8:2471–2478CrossRef

20.

Smolen S, Aletaha D, Steiner G (2009) Does damage cause inflammation? Revisiting the link between joint damage and inflammation. Ann Rheum Dis 68:159–162CrossRefPubMed

21.

Spector TD, Hart DJ, Nandra D et al (1997) Low-level increases in serum C-reactive protein are present in early osteoarthritis of the knee and predict progressivedisease. Arthr Rheum 40:723–727CrossRef

22.

Taylor PC (2002) VEGF and imaging of vessels in rheumatoid arthritis. Arthritis Res 4:99–107CrossRef

23.

Tseng S, Reddi AH, Di Cesare PE (2009) Cartilage Oligomeric matrix protein (COMP): a biomarker of arthritis. Biomark Insights 4:33–44PubMedPubMedCentral

24.

Turesson C, Bergstrom U, Jacobsson LTH et al (2011) Increased cartilage turnover and circulating autoantibodies in different subsets before the clinical onset of rheumatoid arthritis. Ann Rheum Dis 70:520–522CrossRefPubMed

Title: The degree of cartilage degradation assessed by serum biomarker levels changes after arthroscopic knee synovectomy in rheumatoid arthritis patients
Authors: Marina Lipina
Maxim Makarov
Sergey Makarov
Alexander Novikov
Publication date: 01-11-2017
Publisher: Springer Berlin Heidelberg
Published in: International Orthopaedics / Issue 11/2017
Print ISSN: 0341-2695
Electronic ISSN: 1432-5195
DOI: https://doi.org/10.1007/s00264-017-3634-8

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

The degree of cartilage degradation assessed by serum biomarker levels changes after arthroscopic knee synovectomy in rheumatoid arthritis patients

Abstract

Purpose

Methods

Results

Conclusions

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Abstract

Purpose

Methods

Results

Conclusions

Please log in to get access to this content

Other articles of this Issue 11/2017

The horizontal plane appearances of scoliosis: what information can be obtained from top-view images?

Viscosupplementation in patients with severe osteoarthritis of the knee: six month follow-up of a randomized, double-blind clinical trial

Comment on the article “Staphylococcus lugdunensis: a neglected pathogen of infections involving fracture-fixation devices”

Three dimensional printing technology and materials for treatment of elbow fractures

Computer aided planning of orthopaedic surgeries: the definition of generic planning steps for bone removal procedures

Efficacy of pedobarographic analysis to evaluate proximal medial gastrocnemius recession in patients with gastrocnemius tightness and metatarsalgia