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01-11-2017 | Original Paper

Viscosupplementation in patients with severe osteoarthritis of the knee: six month follow-up of a randomized, double-blind clinical trial

Authors: André Luiz Siqueira Campos, Rodrigo Satamini Pires e Albuquerque, Edmilson Barbosa da Silva, Sami Gobbi Fayad, Lucas Delunardo Acerbi, Felipe Nunes de Almeida, Nelson Hiroyuki Myiabe Ooka, José Sergio Franco, Vinícius Schott Gameiro

Published in: International Orthopaedics | Issue 11/2017

Abstract

Purpose

To analyze the early outcomes of viscosupplementation in patients with severe knee osteoarthritis.

Method

A randomized, double-blind clinical trial of 143 knees divided into three groups: Group 1 – intra-articular injection of triamcinolone; Group 2 – hylan GF20; and Group 3 – triamcinolone + hylan GF20. Outcomes were evaluated using Lysholm and KSS scores before treatment and after one, three and six months.

Results

Within-group comparisons revealed improvements in Lysholm scores in all groups in the one month evaluation relative to pre-treatment levels (p < 0.01). This improvement was maintained in the third month after treatment (p > 0.05). Scores at six months were significantly lower than those observed in the previous follow-up assessments (p < 0.05), but still higher than pre-treatment levels (p < 0.05). KSS scores also improved after one month relative to pre-treatment levels (p < 0.01). This improvement was still present at three and six months after treatment in the corticosteroid group (p > 0.05). Patients treated with hylan GF20 showed lower scores in the last evaluation relative to month one (p < 0.05). No significant differences were observed between the treatment groups (p > 0.05).

Conclusions

Viscosupplementation increased functional scores in patients with severe osteoarthritis of the knee, especially within three months of injection. However, it was not superior to the use of triamcinolone.

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Title: Viscosupplementation in patients with severe osteoarthritis of the knee: six month follow-up of a randomized, double-blind clinical trial
Authors: André Luiz Siqueira Campos
Rodrigo Satamini Pires e Albuquerque
Edmilson Barbosa da Silva
Sami Gobbi Fayad
Lucas Delunardo Acerbi
Felipe Nunes de Almeida
Nelson Hiroyuki Myiabe Ooka
José Sergio Franco
Vinícius Schott Gameiro
Publication date: 01-11-2017
Publisher: Springer Berlin Heidelberg
Published in: International Orthopaedics / Issue 11/2017
Print ISSN: 0341-2695
Electronic ISSN: 1432-5195
DOI: https://doi.org/10.1007/s00264-017-3625-9

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Viscosupplementation in patients with severe osteoarthritis of the knee: six month follow-up of a randomized, double-blind clinical trial

Abstract

Purpose

Method

Results

Conclusions

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Abstract

Purpose

Method

Results

Conclusions

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