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International Orthopaedics
Published in: International Orthopaedics 7/2017

Open Access 01-07-2017 | Original Paper

Intercalary frozen autograft for reconstruction of malignant bone and soft tissue tumours

Authors: Karem M. Zekry, Norio Yamamoto, Katsuhiro Hayashi, Akihiko Takeuchi, Takashi Higuchi, Kensaku Abe, Yuta Taniguchi, Ali Zein A. A. Alkhooly, Ahmed Saleh Abd-Elfattah, Ezzat H. Fouly, Adel Refaat Ahmed, Hiroyuki Tsuchiya

Published in: International Orthopaedics | Issue 7/2017

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Abstract

Purpose

In 1999, we developed a technique using frozen autografts—tumour-containing bone treated with liquid nitrogen—for the reconstruction of malignant bone tumours. The purpose of this study was to evaluate the functional and oncological outcomes of frozen autografts for intercalary reconstruction of malignant bones and soft tissue tumours.

Methods

This retrospective study was designed to assess 34 patients of mean age 35 (range, 6–79) years. The mean follow-up period was 62 (24–214) months. The median length of the frozen autografts was 138.4 ± 60.39 (50–290) mm.

Results

Postsurgically, 20 patients remained disease-free, seven patients survived with no evidence of disease, five patients were alive with disease, and two patients died of disease. The five- and ten-year survival rates of the frozen autografts were 91.2% and the mean International Society of Limb Salvage score was 90%. Complete bony union was achieved in 97% of the patients. There were five cases of nonunion, six cases of fracture, two cases of deep infection and four cases of local recurrence.

Conclusion

Utilizing intercalary frozen autografts for patients with a nonosteolytic primary or secondary bone tumour without involvement of the subchondral bone is a good alternative treatment, because it is a straightforward biological technique and can provide excellent limb function.
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Metadata
Title
Intercalary frozen autograft for reconstruction of malignant bone and soft tissue tumours
Authors
Karem M. Zekry
Norio Yamamoto
Katsuhiro Hayashi
Akihiko Takeuchi
Takashi Higuchi
Kensaku Abe
Yuta Taniguchi
Ali Zein A. A. Alkhooly
Ahmed Saleh Abd-Elfattah
Ezzat H. Fouly
Adel Refaat Ahmed
Hiroyuki Tsuchiya
Publication date
01-07-2017
Publisher
Springer Berlin Heidelberg
Published in
International Orthopaedics / Issue 7/2017
Print ISSN: 0341-2695
Electronic ISSN: 1432-5195
DOI
https://doi.org/10.1007/s00264-017-3446-x

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