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International Orthopaedics

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01-06-2016 | Review Article

Increased risk of vertebral fracture in patients with diabetes: a meta-analysis of cohort studies

Authors: Jie Wang, Wenjun You, Zhaohai Jing, Robin Wang, Zhengju Fu, Yangang Wang

Published in: International Orthopaedics | Issue 6/2016

Abstract

Purpose

The relationship between diabetes and risk of fracture has been reported differently in study design and risk estimates, and the relationship between diabetes and risk of vertebral fracture remained unclear. Therefore, we performed a meta-analysis of prospective or retrospective cohort studies to assess the potential relationship between diabetes and vertebral fracture.

Methods

We searched medical databases for prospective or retrospective cohort studies on the association between diabetes and vertebral fracture risk. Pooled relative risks (RR) and corresponding 95 % confidence intervals (95 % CI) were calculated with a random-effects model of meta-analysis.

Results

Meta-analysis of eight studies showed that the pooled RR of vertebral fracture for diabetic individuals was 2.03 (95 % CI 1.60–2.59; p < 0.0001). Subgroup analysis by gender showed that the corresponding RRs for male and female were 2.70 (95 % CI 1.34–5.43; p = 0.005) and 1.93 (95 % CI 1.18–3.13; p = 0.008), respectively. Subgroup analysis by study design showed that the corresponding RRs for prospective design and retrospective design were 1.81 (95 % CI 1.19–2.75; p = 0.006) and 2.23 (95 % CI 1.60–3.10; p < 0.0001), respectively. Subgroup analysis by time of follow-up showed that the RR of vertebral fracture for patients with >20 and <20 years of follow-up were 2.23 (95 % CI 1.98–3.62; p < 0.0001) and 1.67 (95 % CI 1.29–2.16; p < 0.0001), respectively.

Conclusions

Diabetes is an independent risk factor for vertebral fracture, primarily being due to diabetic osteoporosis.

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Title: Increased risk of vertebral fracture in patients with diabetes: a meta-analysis of cohort studies
Authors: Jie Wang
Wenjun You
Zhaohai Jing
Robin Wang
Zhengju Fu
Yangang Wang
Publication date: 01-06-2016
Publisher: Springer Berlin Heidelberg
Published in: International Orthopaedics / Issue 6/2016
Print ISSN: 0341-2695
Electronic ISSN: 1432-5195
DOI: https://doi.org/10.1007/s00264-016-3146-y

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Increased risk of vertebral fracture in patients with diabetes: a meta-analysis of cohort studies

Abstract

Purpose

Methods

Results

Conclusions

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Abstract

Purpose

Methods

Results

Conclusions

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