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Open Access 01-06-2015 | Review Article

The role of adipocytokines in the pathogenesis of knee joint osteoarthritis

Authors: Magdalena Richter, Tomasz Trzeciak, Maciej Owecki, Andrzej Pucher, Jacek Kaczmarczyk

Published in: International Orthopaedics | Issue 6/2015

Abstract

Osteoarthritis (OA) is one of the most common causes of musculoskeletal disability in the world. Traditionally, it has been thought that obesity contributes to the development and progression of OA by increased mechanical load of the joint structures. Nevertheless, studies have shown that adipose tissue-derived cytokines (adipocytokines) are a possible link between obesity and OA. Furthermore, according to recent findings, not only articular cartilage may be the main target of these cytokines but also the synovial membrane, subchondral bone and infrapatellar fat pad may be encompassed in the process of degradation. This review presents the most recent reports on the contribution of adipocytokines to the knee joint cartilage degradation, osteophyte formation, infrapatellar fat pad alterations and synovitis.

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Title: The role of adipocytokines in the pathogenesis of knee joint osteoarthritis
Authors: Magdalena Richter
Tomasz Trzeciak
Maciej Owecki
Andrzej Pucher
Jacek Kaczmarczyk
Publication date: 01-06-2015
Publisher: Springer Berlin Heidelberg
Published in: International Orthopaedics / Issue 6/2015
Print ISSN: 0341-2695
Electronic ISSN: 1432-5195
DOI: https://doi.org/10.1007/s00264-015-2707-9

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

The role of adipocytokines in the pathogenesis of knee joint osteoarthritis

Abstract

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Abstract

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