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International Orthopaedics

Published in:

01-09-2014 | Original Paper

Angiogenic cytokine expression profiles in plasma and synovial fluid of primary knee osteoarthritis

Authors: Thomas Mabey, Sittisak Honsawek, Natthaphon Saetan, Yong Poovorawan, Aree Tanavalee, Pongsak Yuktanandana

Published in: International Orthopaedics | Issue 9/2014

Abstract

Purpose

The aim of this study was to compare angiogenic cytokine levels in knee osteoarthritis (OA) patients and healthy controls and to investigate the relationships between angiogenic cytokines and the OA severity.

Methods

Thirty-one knee OA patients and 15 healthy controls were recruited. Nine angiogenic cytokines (angiopoietin-2, follistatin, granulocyte-colony stimulating factor (G-CSF), hepatocyte growth factor (HGF), interleukin (IL)-8, leptin, platelet-derived growth factor-BB (PDGF-BB), platelet endothelial cell adhesion molecule (PECAM)-1, and vascular endothelial growth factor (VEGF)) in plasma and synovial fluid were measured using a multiplex immunoassay.

Results

PECAM-1, HGF, VEGF, angiopoietin-2, follistatin, G-CSF, and IL-8 concentrations in plasma were significantly higher in OA patients than those in controls. Plasma angiopoietin-2 was significantly greater in advanced OA than in early OA. Synovial fluid VEGF was positively correlated with the severity (r = 0.367, P = 0.04). Plasma follistatin was significantly lower in advanced knee OA than in early OA and was negatively correlated with the severity (r = −0.374, P < 0.05).

Conclusions

Angiogenic cytokine concentrations in plasma can distinguish between controls and OA patients. Local and circulating levels of angiogenic cytokines could give an insight into the pathophysiology of OA. Follistatin, angiopoietin-2, and VEGF may have potential as biochemical markers for the assessment of OA severity.

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Title: Angiogenic cytokine expression profiles in plasma and synovial fluid of primary knee osteoarthritis
Authors: Thomas Mabey
Sittisak Honsawek
Natthaphon Saetan
Yong Poovorawan
Aree Tanavalee
Pongsak Yuktanandana
Publication date: 01-09-2014
Publisher: Springer Berlin Heidelberg
Published in: International Orthopaedics / Issue 9/2014
Print ISSN: 0341-2695
Electronic ISSN: 1432-5195
DOI: https://doi.org/10.1007/s00264-014-2406-y

At a glance: The STEP trials

Springer Medicine

Angiogenic cytokine expression profiles in plasma and synovial fluid of primary knee osteoarthritis

Abstract

Purpose

Methods

Results

Conclusions

At a glance: The STEP trials

Springer Medicine

Abstract

Purpose

Methods

Results

Conclusions

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