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International Orthopaedics
Published in: International Orthopaedics 5/2013

01-05-2013 | Original Paper

Smoking as a predictor of negative outcome in diaphyseal fracture healing

Authors: Jacques Hernigou, Frédéric Schuind

Published in: International Orthopaedics | Issue 5/2013

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Abstract

Purpose

The purpose of this study was to evaluate the impact of tobacco abuse in the consolidation of fractures.

Methods

We retrospectively identified all patients with a diaphyseal fracture (femur, tibia, or humerus), between January 1999 and December 2010, in our orthopaedic trauma registry (Erasme hospital, Brussels, Belgium). Thirty-eight diaphyseal nonunions (ten femurs, 16 tibias and 12 humerus) were identified. Each nonunion was paired (on age, sex and location) with two control-healed fractures (76 control patients). The chi-squared test and a binary logistic regression were used for statistical analysis.

Results

In multivariate analysis, smoking (tobacco use) was significantly associated with nonunion, whether the fracture was open or closed (p < 0.01). In univariate analysis, open fracture was associated with a higher risk of nonunion (p < 0.05), while external fixation was associated with better bone healing (p < 0.05).

Conclusion

Tobacco is confirmed as a deleterious factor for diaphyseal bone healing.
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Metadata
Title
Smoking as a predictor of negative outcome in diaphyseal fracture healing
Authors
Jacques Hernigou
Frédéric Schuind
Publication date
01-05-2013
Publisher
Springer-Verlag
Published in
International Orthopaedics / Issue 5/2013
Print ISSN: 0341-2695
Electronic ISSN: 1432-5195
DOI
https://doi.org/10.1007/s00264-013-1809-5

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