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International Orthopaedics

Published in:

01-10-2012 | Original Paper

Aspirin for elective hip and knee arthroplasty: a multimodal thromboprophylaxis protocol

Authors: Ettore Vulcano, Mark Gesell, Amanda Esposito, Yan Ma, Stavros G. Memtsoudis, Alejandro Gonzalez Della Valle

Published in: International Orthopaedics | Issue 10/2012

Abstract

Purpose

Multimodal thromboprophylaxis includes preoperative thromboembolic risk stratification and autologous blood donation, surgery performed under regional anaesthesia, postoperative rapid mobilisation, use of pneumatic compression devices and chemoprophylaxis tailored to the patient’s individual risk. We determined the 90-day rate of venous thromboembolism (VTE), other complications and mortality in patients who underwent primary elective hip and knee replacement surgery with multimodal thromboprophylaxis.

Methods

A total of 1,568 consecutive patients undergoing hip and knee replacement surgery received multimodal thromboprophylaxis: 1,115 received aspirin, 426 received warfarin and 27 patients received low molecular weight heparin and warfarin with or without a vena cava filter.

Results

The rate of VTE, pulmonary embolism, proximal deep vein thrombosis (DVT) and distal DVT was 1.2, 0.36, 0.45 and 0.36 %, respectively, in patients who received aspirin. The rates in those who received warfarin were 1.4, 0.9, 0.47 and 0.47 %, respectively. The overall 90-day mortality rate was 0.2 %.

Conclusions

Multimodal thromboprophylaxis in which aspirin is administered to low-risk patients is safe and effective following primary total joint replacement.

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Title: Aspirin for elective hip and knee arthroplasty: a multimodal thromboprophylaxis protocol
Authors: Ettore Vulcano
Mark Gesell
Amanda Esposito
Yan Ma
Stavros G. Memtsoudis
Alejandro Gonzalez Della Valle
Publication date: 01-10-2012
Publisher: Springer-Verlag
Published in: International Orthopaedics / Issue 10/2012
Print ISSN: 0341-2695
Electronic ISSN: 1432-5195
DOI: https://doi.org/10.1007/s00264-012-1588-4

At a glance: The STEP trials

Springer Medicine

Aspirin for elective hip and knee arthroplasty: a multimodal thromboprophylaxis protocol

Abstract

Purpose

Methods

Results

Conclusions

At a glance: The STEP trials

Springer Medicine

Abstract

Purpose

Methods

Results

Conclusions

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