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International Orthopaedics

Published in:

01-05-2012 | Original Paper

Correlation between plasma and synovial fluid basic fibroblast growth factor with radiographic severity in primary knee osteoarthritis

Authors: Sittisak Honsawek, Pongsak Yuktanandana, Aree Tanavalee, Natthaphon Saetan, Wilai Anomasiri, Vinai Parkpian

Published in: International Orthopaedics | Issue 5/2012

Abstract

Purpose

The aim of this study was to investigate plasma and synovial fluid basic fibroblast growth factor (bFGF) levels in patients with primary knee osteoarthritis (OA) and to evaluate the correlation between bFGF levels and disease severity.

Methods

Thirty-five patients with knee OA and 15 healthy individuals were recruited into this study. Knee OA grading was performed according to the Kellgren–Lawrence classification. bFGF concentrations in both plasma and synovial fluid were determined using enzyme-linked immunosorbent assay.

Results

Plasma and synovial fluid bFGF levels in knee OA patients were significantly higher than in controls (P < 0.001). Moreover, plasma and synovial fluid bFGF concentrations were positively correlated with radiographic severity (r = 0.535, P < 0.001 and r = 0.570, P < 0.001, respectively). Further analysis revealed that there was a positive correlation between plasma and synovial fluid bFGF levels (r = 0.674, P < 0.001).

Conclusions

Plasma and synovial fluid bFGF levels were significantly increased in OA patients, and these elevated levels were positively correlated with radiographic severity. These findings indicate that bFGF levels may be a monitor of disease severity and could play an essential part in the pathophysiology of degenerative process in OA.

Abraham JA, Whang JL, Tumolo A, Mergia A, Friedman J, Gospodarowicz D, Fiddes JC (1986) Human basic fibroblast growth factor: nucleotide sequence and genomic organization. EMBO J 5:2523–2528PubMed

Alzheimer C, Werner S (2002) Fibroblast growth factors and neuroprotection. Adv Exp Med Biol 513:335–351PubMedCrossRef

Anitua E, Sánchez M, de la Fuente M, Azofra J, Zalduendo M, Aguirre JJ, Andía I (2009) Relationship between investigative biomarkers and radiographic grading in patients with knee osteoarthritis. Int J Rheumatol 2009:747432PubMed

Barrientos S, Stojadinovic O, Golinko MS, Brem H, Tomic-Canic M (2008) Growth factors and cytokines in wound healing. Wound Repair Regen 16:585–601PubMedCrossRef

Bikfalvi A, Klein S, Pintucci G, Rifkin DB (1997) Biological roles of fibroblast growth factor-2. Endocr Rev 18:26–45PubMedCrossRef

Chia SL, Sawaji Y, Burleigh A, McLean C, Inglis J, Saklatvala J, Vincent T (2009) Fibroblast growth factor 2 is an intrinsic chondroprotective agent that suppresses ADAMTS-5 and delays cartilage degradation in murine osteoarthritis. Arthritis Rheum 60:2019–2027PubMedCrossRef

Friesel RE, Maciag T (1995) Molecular mechanisms of angiogenesis: fibroblast growth factor signal transduction. FASEB J 9:919–925PubMed

Fujisato T, Sajiki T, Liu Q, Ikada Y (1996) Effect of basic fibroblast growth factor on cartilage regeneration in chondrocyte-seeded collagen sponge scaffold. Biomaterials 17:155–162PubMedCrossRef

Honsawek S, Chayanupatkul M, Tanavalee A, Sakdinakiattikoon M, Deepaisarnsakul B, Yuktanandana P, Ngarmukos S (2009) Relationship of plasma and synovial fluid BMP-7 with disease severity in knee osteoarthritis patients: a pilot study. Int Orthop 33:1171–1175PubMedCrossRef

10.

Honsawek S, Tanavalee A, Sakdinakiattikoon M, Chayanupatkul M, Yuktanandana P (2009) Correlation of plasma and synovial fluid osteopontin with disease severity in knee osteoarthritis. Clin Biochem 42:808–812PubMedCrossRef

11.

Jingushi S, Shida J, Iwamoto Y, Kinoshita T, Hiyama Y, Tamura M, Izumi T (2006) Transient exposure of fibroblast growth factor-2 induced proliferative but not destructive changes in mouse knee joints. Connect Tissue Res 47:242–248PubMedCrossRef

12.

Kellgren JH, Lawrence JS (1957) Radiological assessment of osteo-arthrosis. Ann Rheum Dis 16:494–502PubMedCrossRef

13.

Khan IM, Palmer EA, Archer CW (2010) Fibroblast growth factor-2 induced chondrocyte cluster formation in experimentally wounded articular cartilage is blocked by soluble Jagged-1. Osteoarthr Cartil 18:208–219PubMedCrossRef

14.

Kraus VB (1997) Pathogenesis and treatment of osteoarthritis. Med Clin North Am 81:85–112PubMedCrossRef

15.

Ku JH, Lee CK, Joo BS, An BM, Choi SH, Wang TH, Cho HL (2009) Correlation of synovial fluid leptin concentrations with the severity of osteoarthritis. Clin Rheumatol 28:1431–1435PubMedCrossRef

16.

Kurokawa T, Sasada R, Iwane M, Igarashi K (1987) Cloning and expression of cDNA encoding human basic fibroblast growth factor. FEBS Lett 213:189–194PubMedCrossRef

17.

Muddasani P, Norman JC, Ellman M, van Wijnen AJ, Im HJ (2007) Basic fibroblast growth factor activates the MAPK and NFkappaB pathways that converge on Elk-1 to control production of matrix metalloproteinase-13 by human adult articular chondrocytes. J Biol Chem 282:31409–31421PubMedCrossRef

18.

Okada-Ban M, Thiery JP, Jouanneau J (2000) Fibroblast growth factor-2. Int J Biochem Cell Biol 32:263–267PubMedCrossRef

19.

Orito K, Koshino T, Saito T (2003) Fibroblast growth factor 2 in synovial fluid from an osteoarthritic knee with cartilageregeneration. J Orthop Sci 8:294–300PubMedCrossRef

20.

Przybylski M (2009) A review of the current research on the role of bFGF and VEGF in angiogenesis. J Wound Care 18:516–519PubMed

21.

Qu Z, Huang XN, Ahmadi P, Andresevic J, Planck SR, Hart CE, Rosenbaum JT (1995) Expression of basic fibroblast growth factor in synovial tissue from patients with rheumatoid arthritis anddegenerative joint disease. Lab Invest 73:339–346PubMed

22.

Quintavalla J, Kumar C, Daouti S, Slosberg E, Uziel-Fusi S (2005) Chondrocyte cluster formation in agarose cultures as a functional assay to identify genes expressed in osteoarthritis. J Cell Physiol 204:560–566PubMedCrossRef

23.

Saetan N, Honsawek S, Tanavalee A, Tantavisut S, Yuktanandana P, Parkpian V (2011) Association of plasma and synovial fluid interferon-γ inducible protein-10 with radiographic severity in knee osteoarthritis. Clin Biochem 44:1218–1222PubMedCrossRef

24.

Sato J, Segami N, Kaneyama K, Konishi H, Yoshitake Y, Nishikawa K (2003) Levels of fibroblast growth factor 2 in synovial fluids in human patients with internal derangement of the temporomandibular joint. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 96:673–679PubMedCrossRef

25.

Tchetina EV, Squires G, Poole AR (2005) Increased type II collagen degradation and very early focal cartilage degeneration is associated with upregulation of chondrocyte differentiation related genes in early humanarticular cartilage lesions. J Rheumatol 32:876–886PubMed

26.

Thomas KA (1987) Fibroblast growth factors. FASEB J 1:434–440PubMed

27.

Uchino M, Izumi T, Tominaga T, Wakita R, Minehara H, Sekiguchi M, Itoman M (2003) Growth factor expression in the osteophytes of the human femoral head in osteoarthritis. Clin Orthop Relat Res 377:119–125CrossRef

28.

Ushiyama T, Chano T, Inoue K, Matsusue Y (2003) Cytokine production in the infrapatellar fat pad: another source of cytokines in knee synovial fluids. Ann Rheum Dis 62:108–112PubMedCrossRef

Title: Correlation between plasma and synovial fluid basic fibroblast growth factor with radiographic severity in primary knee osteoarthritis
Authors: Sittisak Honsawek
Pongsak Yuktanandana
Aree Tanavalee
Natthaphon Saetan
Wilai Anomasiri
Vinai Parkpian
Publication date: 01-05-2012
Publisher: Springer-Verlag
Published in: International Orthopaedics / Issue 5/2012
Print ISSN: 0341-2695
Electronic ISSN: 1432-5195
DOI: https://doi.org/10.1007/s00264-011-1435-z

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Correlation between plasma and synovial fluid basic fibroblast growth factor with radiographic severity in primary knee osteoarthritis

Abstract

Purpose

Methods

Results

Conclusions

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Purpose

Methods

Results

Conclusions

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