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International Orthopaedics
Published in: International Orthopaedics 2/2009

01-04-2009 | Original Paper

Correlation between synovial fluid and serum IL-1β levels after ACL surgery–preliminary report

Authors: Nikica Darabos, Zeljka Hundric-Haspl, Miroslav Haspl, Alemka Markotic, Anela Darabos, Carsten Moser

Published in: International Orthopaedics | Issue 2/2009

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Abstract

The possibility of controlling the harmful intra-articular influence of elevated interleukin (IL)-1β synovial fluid concentration after anterior cruciate ligament (ACL) surgery could be useful. We investigated the correlation between serum and synovial fluid IL-1β levels following ACL reconstruction. We measured IL-1β concentration periodically in three synovial fluid and four serum samples in each of 20 patients receiving either autologous conditioned serum (ACS) containing endogenous anti-inflammatory cytokines including IL-1Ra and several growth factors (group A) or placebo (group B). A decrease in IL-1β synovial fluid concentration appeared to be more pronounced in absolute terms in group A. In eight patients serum IL-1β was detected on the 6th postoperative day. In four of them whose synovial fluid levels were over 10 pg/ml on the 6th postoperative day, serum IL-1β was detected on the 10th postoperative day. The results were different in group B. Correlation between serum and synovial fluid IL-1β appearance persists in patients after ACL surgery and ACS application. This study is an example of ACS influence on the ACL healing process controlling the IL-1β levels on the basis of the serum IL-1β detection.
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Metadata
Title
Correlation between synovial fluid and serum IL-1β levels after ACL surgery–preliminary report
Authors
Nikica Darabos
Zeljka Hundric-Haspl
Miroslav Haspl
Alemka Markotic
Anela Darabos
Carsten Moser
Publication date
01-04-2009
Publisher
Springer-Verlag
Published in
International Orthopaedics / Issue 2/2009
Print ISSN: 0341-2695
Electronic ISSN: 1432-5195
DOI
https://doi.org/10.1007/s00264-008-0649-1

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