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International Orthopaedics
Published in: International Orthopaedics 2/2009

01-04-2009 | Original Paper

Experimental study of nano-HA artificial bone with different pore sizes for repairing the radial defect

Authors: Weimin Zhu, Jiande Xiao, Daping Wang, Jianquan Liu, Jianyi Xiong, Lijun Liu, Xiaojun Zhang, Yanjun Zeng

Published in: International Orthopaedics | Issue 2/2009

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Abstract

The purpose of this study was to examine the repairing ability of nano-hydroxyapatite (nano-HA) artificial bone with different pore sizes. Animal models of bone defects were created in both radii of 60 New Zealand white rabbits. The bone defects in A, B, and C groups were repaired with nano-HA artificial bone with three different pore sizes while those in group D were left unrepaired. The repairing ability of material was evaluated by gross observation, histopathological study, X-ray examination, scanning electron microscope (SEM), and biomechanical analysis in the fourth, eighth, and 12th weeks. Group B stimulated more bone formation than the other groups. Nano-HA artificial bone is capable of good bone formation and biocompatibility. The ability of bone formation of nano-HA artificial bone may be affected significantly by the pore size. The material with pore size in the range of 100 –250 μm has a greater ability to form bone.
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Metadata
Title
Experimental study of nano-HA artificial bone with different pore sizes for repairing the radial defect
Authors
Weimin Zhu
Jiande Xiao
Daping Wang
Jianquan Liu
Jianyi Xiong
Lijun Liu
Xiaojun Zhang
Yanjun Zeng
Publication date
01-04-2009
Publisher
Springer-Verlag
Published in
International Orthopaedics / Issue 2/2009
Print ISSN: 0341-2695
Electronic ISSN: 1432-5195
DOI
https://doi.org/10.1007/s00264-008-0572-5

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