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Cancer Immunology, Immunotherapy
Published in: Cancer Immunology, Immunotherapy 5/2014

Open Access 01-05-2014 | Review

Interleukin 12: still a promising candidate for tumor immunotherapy?

Authors: Witold Lasek, Radosław Zagożdżon, Marek Jakobisiak

Published in: Cancer Immunology, Immunotherapy | Issue 5/2014

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Abstract

Interleukin 12 (IL-12) seemed to represent the ideal candidate for tumor immunotherapy, due to its ability to activate both innate (NK cells) and adaptive (cytotoxic T lymphocytes) immunities. However, despite encouraging results in animal models, very modest antitumor effects of IL-12 in early clinical trials, often accompanied by unacceptable levels of adverse events, markedly dampened  hopes of the successful use of this cytokine in cancer patients. Recently, several clinical studies have been initiated in which IL-12 is applied as an adjuvant in cancer vaccines, in gene therapy including locoregional injections of IL-12 plasmid and in the form of tumor-targeting immunocytokines (IL-12 fused to monoclonal antibodies). The near future will show whether this renewed interest in the use of IL-12 in oncology will result in meaningful therapeutic effects in a select group of cancer patients.
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Metadata
Title
Interleukin 12: still a promising candidate for tumor immunotherapy?
Authors
Witold Lasek
Radosław Zagożdżon
Marek Jakobisiak
Publication date
01-05-2014
Publisher
Springer Berlin Heidelberg
Published in
Cancer Immunology, Immunotherapy / Issue 5/2014
Print ISSN: 0340-7004
Electronic ISSN: 1432-0851
DOI
https://doi.org/10.1007/s00262-014-1523-1

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