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Cancer Immunology, Immunotherapy
Published in: Cancer Immunology, Immunotherapy 8/2011

01-08-2011 | Review

Cooperativity of adaptive and innate immunity: implications for cancer therapy

Authors: Anil Shanker, Francesco M. Marincola

Published in: Cancer Immunology, Immunotherapy | Issue 8/2011

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Abstract

The dichotomy of immunology into innate and adaptive immunity has created conceptual barriers in appreciating the intrinsic two-way interaction between immune cells. An emerging body of evidence in various models of immune rejection, including cancer, indicates an indispensable regulation of innate effector functions by adaptive immune cells. This bidirectional cooperativity in innate and adaptive immune functions has broad implications for immune responses in general and for regulating the tumor-associated inflammation that overrides the protective antitumor immunity. Mechanistic understanding of this two-way immune cross-talk could provide insights into novel strategies for designing better immunotherapy approaches against cancer and other diseases that normally defy immune control.
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Metadata
Title
Cooperativity of adaptive and innate immunity: implications for cancer therapy
Authors
Anil Shanker
Francesco M. Marincola
Publication date
01-08-2011
Publisher
Springer-Verlag
Published in
Cancer Immunology, Immunotherapy / Issue 8/2011
Print ISSN: 0340-7004
Electronic ISSN: 1432-0851
DOI
https://doi.org/10.1007/s00262-011-1053-z

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Focussed Research Review

Ten years of progress in vaccination against cancer: the need to counteract cancer evasion by dual targeting in future therapies

Meeting report

Tenth International Conference on Progress in Vaccination Against Cancer (PIVAC 10), Cambridge, UK, 27th–30th September 2010: New hopes and strategies for cancer vaccines

Focussed Research Review

Camouflage and sabotage: tumor escape from the immune system

Original article

Phase I/II study of adoptive transfer of γδ T cells in combination with zoledronic acid and IL-2 to patients with advanced renal cell carcinoma

Focussed Research Review

Immunotherapy of prostate cancer: should we be targeting stem cells and EMT?

Original Article

Foxp3 expression in melanoma cells as a possible mechanism of resistance to immune destruction
Webinar | 19-02-2024 | 17:30 (CET)

Keynote webinar | Spotlight on antibody–drug conjugates in cancer

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Antibody–drug conjugates (ADCs) are novel agents that have shown promise across multiple tumor types. Explore the current landscape of ADCs in breast and lung cancer with our experts, and gain insights into the mechanism of action, key clinical trials data, existing challenges, and future directions.

Dr. Véronique Diéras
Prof. Fabrice Barlesi
Developed by: Springer Medicine
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