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Cancer Immunology, Immunotherapy
Published in: Cancer Immunology, Immunotherapy 10/2008

01-10-2008 | Symposium Paper

NK cell-mediated targeting of human cancer and possibilities for new means of immunotherapy

Authors: Karl-Johan Malmberg, Yenan T. Bryceson, Mattias Carlsten, Sandra Andersson, Andreas Björklund, Niklas K. Björkström, Bettina C. Baumann, Cyril Fauriat, Evren Alici, M. Sirac Dilber, Hans-Gustaf Ljunggren

Published in: Cancer Immunology, Immunotherapy | Issue 10/2008

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Abstract

Insights into the molecular basis for natural killer (NK) cell recognition of human cancer have been obtained in recent years. Here, we review current knowledge on the molecular specificity and function of human NK cells. Evidence for NK cell targeting of human tumors is provided and new strategies for NK cell-based immunotherapy against human cancer are discussed. Based on current knowledge, we foresee a development where more cancers may be subject to treatment with drugs or other immunomodulatory agents affecting NK cells, either directly or indirectly. We also envisage a possibility that certain forms of cancers may be subject to treatment with adoptively transferred NK cells, either alone or in combination with other therapeutic interventions.
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Metadata
Title
NK cell-mediated targeting of human cancer and possibilities for new means of immunotherapy
Authors
Karl-Johan Malmberg
Yenan T. Bryceson
Mattias Carlsten
Sandra Andersson
Andreas Björklund
Niklas K. Björkström
Bettina C. Baumann
Cyril Fauriat
Evren Alici
M. Sirac Dilber
Hans-Gustaf Ljunggren
Publication date
01-10-2008
Publisher
Springer-Verlag
Published in
Cancer Immunology, Immunotherapy / Issue 10/2008
Print ISSN: 0340-7004
Electronic ISSN: 1432-0851
DOI
https://doi.org/10.1007/s00262-008-0492-7

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