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Cancer Immunology, Immunotherapy
Published in: Cancer Immunology, Immunotherapy 11/2006

01-11-2006 | Original Article

Expression of macrophage-derived chemokine (MDC)/CCL22 in human lung cancer

Authors: Toru Nakanishi, Kazuyoshi Imaizumi, Yoshinori Hasegawa, Tsutomu Kawabe, Naozumi Hashimoto, Masakazu Okamoto, Kaoru Shimokata

Published in: Cancer Immunology, Immunotherapy | Issue 11/2006

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Abstract

Background: Ligands for CXCR3 chemokines [IFN-γ-inducible protein of 10 kD (IP-10/CXCL10), monokine induced by IFN-γ (Mig/CXCL9), IFN-inducible T cell α chemoattractant (I-TAC/CXCL11)] and those for CCR4 [macrophage-derived chemokine (MDC/CCL22), thymus- and activation-regulated chemokine (TARC/CCL17)] have been shown to play the central roles for T helper-cell recruitment into the tissues. To examine the role of these chemokines in tumor progression of lung cancer, we investigated their expression in human lung cancer tissues to determine the possible relationship between their expression and the prognosis of patients. Methods: Total RNA was prepared from lung cancer tissues of 40 patients (24 adenocarcinoma and 16 squamous cell carcinoma). We measured gene expression levels of chemokines (IP-10, Mig, I-TAC, MDC and TARC) by real-time quantitative RT-PCR. Results: Higher gene expression of MDC in lung cancer was significantly correlated with longer disease-free survival time and lower risk of recurrence after tumor resection. We could not find any significant relationship of IP-10, Mig, I-TAC and TARC gene expression with disease-free survival or lower risk of recurrence after surgery. Conclusions: These results suggest that increased gene expression of MDC in tumor tissues may be a predictive marker for improving the prognosis of lung cancer.
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Metadata
Title
Expression of macrophage-derived chemokine (MDC)/CCL22 in human lung cancer
Authors
Toru Nakanishi
Kazuyoshi Imaizumi
Yoshinori Hasegawa
Tsutomu Kawabe
Naozumi Hashimoto
Masakazu Okamoto
Kaoru Shimokata
Publication date
01-11-2006
Publisher
Springer-Verlag
Published in
Cancer Immunology, Immunotherapy / Issue 11/2006
Print ISSN: 0340-7004
Electronic ISSN: 1432-0851
DOI
https://doi.org/10.1007/s00262-006-0133-y

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