Published in:
01-03-2004 | Review
Exosome-based immunotherapy
Authors:
Nathalie Chaput, Julien Taïeb, Noël E. C. Schartz, Fabrice André, Eric Angevin, Laurence Zitvogel
Published in:
Cancer Immunology, Immunotherapy
|
Issue 3/2004
Login to get access
Abstract
Exosomes are small membrane vesicles originating from late endosomes and secreted by hematopoietic and epithelial cells in culture. Exosome proteic and lipid composition is unique and might shed some light into exosome biogenesis and function. Exosomes secreted from professional antigen-presenting cells (i.e., B lymphocytes and dendritic cells) are enriched in MHC class I and II complexes, costimulatory molecules, and hsp70–90 chaperones, and have therefore been more extensively studied for their immunomodulatory capacities in vitro and in vivo. This review will present the main biological features pertaining to tumor or DC-derived exosomes, will emphasize their immunostimulatory function, and will discuss their implementation in cancer immunotherapy.