Published in:
01-11-2003 | Symposium in Writing
Modulation of costimulation to enhance tumor immunity
Authors:
Bridget Vesosky, Arthur A. Hurwitz
Published in:
Cancer Immunology, Immunotherapy
|
Issue 11/2003
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Excerpt
It is widely accepted that two signals are required for efficient T-cell activation. T cells receive their first, antigen-specific signal following ligation of TCR by MHC-peptide complexes. The second signal, which is antigen-independent, is delivered by ligation of CD28 by CD80 or CD86 (B7-1 or B7-2). The importance of this second, costimulatory signal has been clearly demonstrated. T cells receiving an antigen-specific signal without costimulation may become unresponsive. In addition to CD28, many other important costimulatory pathways have been described. …