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European Journal of Nuclear Medicine and Molecular Imaging

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17-03-2022 | Heart Failure | Original Article

Clinical significance of ¹²³I-BMIPP washout rate in patients with uncertain chronic heart failure

Authors: Chihiro Aoshima, Shinichiro Fujimoto, Ayako Kudo, Yuko O. Kawaguchi, Kazuhisa Takamura, Yuya Matsue, Takao Kato, Yoshifumi Kawamura, Satoshi Kimura, Yuki Kamo, Yui O. Nozaki, Daigo Takahashi, Nobuo Tomizawa, Makoto Hiki, Takatoshi Kasai, Shuko Nojiri, Hideyuki Miyauchi, Ken-ichi Hirano, Kazunori Shimada, Koji Murakami, Tohru Minamino

Published in: European Journal of Nuclear Medicine and Molecular Imaging | Issue 9/2022

Abstract

Background

Recently, triglyceride deposit cardiomyovasculopathy (TGCV) with defective intracellular lipolysis was found to be a disease that causes heart failure. As a diagnostic criterion for TGCV, an Iodaine-123-β-methyl iodophenyl-pentadecanoic acid washout rate (BMIPP WOR) of < 10% is used, but its clinical significance in patients with heart failure remains to be clarified.

Methods

In 62 hospitalized patients with chronic heart failure, ¹²³I-BMIPP myocardial single-photon emission computed tomography (SPECT) was performed predischarge state. The prevalence of TGCV was investigated. Subsequently, follow-up was conducted for ≥ 90 days (mean: 724.6 ± 392.7 days), and the association between the BMIPP WOR and cardiac events was examined, establishing all-cause mortality and admission due to heart failure as endpoints.

Results

Of the 62 patients, the WOR was < 10% in 41 (66.1%). Of these, 26 (41.9%) were diagnosed with definite TGCV. Furthermore, cardiac events were noted in 12 patients (19.4%). Analysis with Cox proportional hazards models showed that the BMIPP WOR < 4.5% was a significant event-predicting factor [HR 4.29, 95% CI: 1.20–16.87; p = 0.0245]. On a Kaplan–Meier curve, the WOR was 4.5%; there was a significant difference in the incidence of events (p = 0.0298).

Conclusion

In the predischarge state of heart failure, ¹²³I-BMIPP myocardial SPECT was performed. In approximately 40% of the patients, a diagnosis of TGCV was made. The results suggested that the BMIPP WOR is useful for predicting the prognosis of chronic heart failure patients regardless of TGCV.

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Title: Clinical significance of 123I-BMIPP washout rate in patients with uncertain chronic heart failure
Authors: Chihiro Aoshima
Shinichiro Fujimoto
Ayako Kudo
Yuko O. Kawaguchi
Kazuhisa Takamura
Yuya Matsue
Takao Kato
Yoshifumi Kawamura
Satoshi Kimura
Yuki Kamo
Yui O. Nozaki
Daigo Takahashi
Nobuo Tomizawa
Makoto Hiki
Takatoshi Kasai
Shuko Nojiri
Hideyuki Miyauchi
Ken-ichi Hirano
Kazunori Shimada
Koji Murakami
Tohru Minamino
Publication date: 17-03-2022
Publisher: Springer Berlin Heidelberg
Keywords: Heart Failure
Chronic Heart Failure
Published in: European Journal of Nuclear Medicine and Molecular Imaging / Issue 9/2022
Print ISSN: 1619-7070
Electronic ISSN: 1619-7089
DOI: https://doi.org/10.1007/s00259-022-05749-1

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Clinical significance of ¹²³I-BMIPP washout rate in patients with uncertain chronic heart failure

Abstract

Background

Methods

Results

Conclusion

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Abstract

Background

Methods

Results

Conclusion

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