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European Journal of Nuclear Medicine and Molecular Imaging

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01-03-2020 | Multiple Myeloma | Original Article

Chemokine receptor-4 targeted PET/CT with ⁶⁸Ga-Pentixafor in assessment of newly diagnosed multiple myeloma: comparison to ¹⁸F-FDG PET/CT

Authors: Qingqing Pan, Xinxin Cao, Yaping Luo, Jian Li, Jun Feng, Fang Li

Published in: European Journal of Nuclear Medicine and Molecular Imaging | Issue 3/2020

Abstract

Purpose

¹⁸F-FDG PET/CT has some limitations in the evaluation of multiple myeloma (MM). Since chemokine receptor-4 is overexpressed in MM, we perform a prospective cohort study to compare the performance of ⁶⁸Ga-Pentixafor and ¹⁸F-FDG PET/CT in newly diagnosed MM.

Methods

Thirty patients with newly diagnosed MM were recruited. All patients underwent ⁶⁸Ga-Pentixafor and¹⁸F-FDG PET/CT within 1 week after enrollment. A positive PET/CT was defined as the presence of focal PET-positive lesions in bone marrow or diffuse bone marrow patterns (uptake > liver). Bone marrow uptake values in ⁶⁸Ga-Pentixafor and¹⁸F-FDG PET/CT (total bone marrow glycolysis [TBmG_FDG], total bone marrow uptake with ⁶⁸Ga-Pentixafor [TBmU_CXCR4], total bone marrow volume [TBmV], SUVmean, and SUVmax) were obtained by drawing total bone marrow volume of interest on PET/CT. The positive rates of the PET/CT scans were statistically compared, and the correlation between quantitative bone marrow uptake values and clinical characteristics, laboratory findings, and staging was analyzed.

Results

⁶⁸Ga-Pentixafor PET/CT had a higher positive rate than ¹⁸F-FDG PET/CT in recruited patients (93.3 vs. 53.3%, p = 0.0005). In quantitative analysis, bone marrow uptake values in ⁶⁸Ga-Pentixafor (TBmU_CXCR4, SUVmax, and SUVmean) were positively correlated with end organ damage, staging, and laboratory biomarkers related to tumor burden including serum β2-microglobulin, serum free light chain, and 24-h urine light chain (p < 0.05). In ¹⁸F-FDG PET/CT, only the SUVmean of total bone marrow was positively correlated with serum free light chain and 24-h urine light chain (p < 0.05).

Conclusions

⁶⁸Ga-Pentixafor PET/CT is promising in assessment of newly diagnosed MM.

Trial registration number

NCT 03436342

Available only for authorised users

Two patients (patients 2 and 5) had bone marrow plasma cells lower than 10%. Patient 2 was presented with biopsy-proven plasmacytoma in T3 vertebra. In patient 5, the plasma cells in bone marrow core biopsy were 70% (however, 4% in bone marrow aspirates).

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Title: Chemokine receptor-4 targeted PET/CT with 68Ga-Pentixafor in assessment of newly diagnosed multiple myeloma: comparison to 18F-FDG PET/CT
Authors: Qingqing Pan
Xinxin Cao
Yaping Luo
Jian Li
Jun Feng
Fang Li
Publication date: 01-03-2020
Publisher: Springer Berlin Heidelberg
Keyword: Multiple Myeloma
Published in: European Journal of Nuclear Medicine and Molecular Imaging / Issue 3/2020
Print ISSN: 1619-7070
Electronic ISSN: 1619-7089
DOI: https://doi.org/10.1007/s00259-019-04605-z

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Chemokine receptor-4 targeted PET/CT with ⁶⁸Ga-Pentixafor in assessment of newly diagnosed multiple myeloma: comparison to ¹⁸F-FDG PET/CT

Abstract

Purpose

Methods

Results

Conclusions

Trial registration number

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Abstract

Purpose

Methods

Results

Conclusions

Trial registration number

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