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European Journal of Nuclear Medicine and Molecular Imaging

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01-10-2019 | Diarrhea | Original Article

Quality of life in patients with midgut NET following peptide receptor radionuclide therapy

Authors: Milka Marinova, Martin Mücke, Felix Fischer, Markus Essler, Henning Cuhls, Lukas Radbruch, Shiwa Ghaei, Rupert Conrad, Hojjat Ahmadzadehfar

Published in: European Journal of Nuclear Medicine and Molecular Imaging | Issue 11/2019

Abstract

Objectives

There is convincing evidence that peptide receptor radionuclide therapy (PRRT) using ¹⁷⁷Lu-DOTATATE compared to octreotide therapy has a positive effect on overall survival and progression-free survival in midgut neuroendocrine tumors (NET). The current study analyzed health-related quality of life (QoL) in patients undergoing PRRT with a special focus on differences in functional performance.

Materials and methods

In our study, 70 patients (39 men or 31 female) suffering from midgut NET were included, with a mean age of 64.2 years. Functional performance was assessed by the index of the Eastern Cooperative of Oncology Group (ECOG). Thirty-three patients (47%) showed ECOG 0, 31 patients (44%) ECOG 1, and six patients (9%) ECOG 2. Health-related QoL was assessed by the EORTC QLQ-C30 questionnaire filled in at baseline and 3 months after each PRRT cycle.

Results

The median cumulative administered activity was 27.4 GBq. Global health status significantly improved compared to baseline status after 1st (p = 0.05), 2nd (p = 0.004), and 3rd (p = 0.04) treatment cycle. Analyzing specific aspects of QoL, emotional functioning significantly improved after 1st and 2nd treatment cycle (both p < 0.001) as well as after 3rd cycle (p = 0.001). With regard to cognitive functioning, there was a significant improvement after 1st and 2nd treatment cycle (p = 0.003 and p = 0.05 respectively). With regard to alleviation of somatic symptoms, a significant reduction in pain and diarrhea was observed after the 2nd cycle (p = 0.038) and 3rd cycle (p = 0.036). Furthermore, changes in QoL in relation to functional performance status as assessed by ECOG were analyzed. There were no significant differences with regard to QoL alterations between patients with high (ECOG 0 or 1) and moderate performance status.

Conclusion

Our study confirmed an equally positive effect of PRRT on quality of life in midgut NET patients with high or moderate functional status in terms of increasing global health, functional status, and alleviating symptoms.

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Title: Quality of life in patients with midgut NET following peptide receptor radionuclide therapy
Authors: Milka Marinova
Martin Mücke
Felix Fischer
Markus Essler
Henning Cuhls
Lukas Radbruch
Shiwa Ghaei
Rupert Conrad
Hojjat Ahmadzadehfar
Publication date: 01-10-2019
Publisher: Springer Berlin Heidelberg
Keywords: Diarrhea
Radionuclide Therapy
Diarrhea
Neuroendocrine Tumor
Published in: European Journal of Nuclear Medicine and Molecular Imaging / Issue 11/2019
Print ISSN: 1619-7070
Electronic ISSN: 1619-7089
DOI: https://doi.org/10.1007/s00259-019-04431-3

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Quality of life in patients with midgut NET following peptide receptor radionuclide therapy

Abstract

Objectives

Materials and methods

Results

Conclusion

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Abstract

Objectives

Materials and methods

Results

Conclusion

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