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European Journal of Nuclear Medicine and Molecular Imaging

Published in:

01-09-2019 | Metastasis | Review Article

Hybrid PET/MRI in major cancers: a scoping review

Authors: Anni Morsing, Malene Grubbe Hildebrandt, Mie Holm Vilstrup, Sara Elisabeth Wallenius, Oke Gerke, Henrik Petersen, Allan Johansen, Thomas Lund Andersen, Poul Flemming Høilund-Carlsen

Published in: European Journal of Nuclear Medicine and Molecular Imaging | Issue 10/2019

Abstract

Purpose

PET/MRI was introduced for clinical use in 2011 and is now an established modality for the imaging of brain and certain pelvic cancers, whereas clinical use for the imaging of other forms of cancer is not yet widespread. We therefore systematically investigated what has been published on the use of PET/MRI compared to PET/CT in the imaging of cancers outside the brain, focusing on clinical areas of application related to diagnosis, staging and restaging.

Methods

A systematic search of PubMed/MEDLINE, Embase and the Cochrane Library was performed. Studies evaluating the diagnostic performance of simultaneous PET/MRI in cancer patients were chosen.

Results

A total of 3,138 publications were identified and 116 published during the period 2012–2018 were included and were grouped according to the major cancer forms: 13 head and neck (HNC), 9 breast (BC), 21 prostate (PC), 14 gynaecological, 13 gastrointestinal (GIC), and 46 various cancers. Data from studies comparing PET/MRI and PET/CT for staging/restaging suggested the superiority of ¹⁸F-FDG PET/MRI for the detection of tumour extension and retropharyngeal lymph node metastases in nasopharyngeal cancer, and for the detection of liver metastases and possibly bone marrow metastases in high-risk BC. FDG PET/MRI tended to be inferior for the detection of lung metastases in HNC and BC. ⁶⁸Ga-PSMA-11 PET/MRI was superior to PET/CT for the detection of local PC recurrence. FDG PET/MRI was superior to FDG PET/CT for the detection of local tumour invasion in cervical cancer and had higher accuracy for the detection of liver metastases in colorectal cancer.

Conclusion

The scoping review methodology resulted in the identification of a huge number of records, of which less than 5% were suitable for inclusion and only a limited number allowed conclusions on the advantages/disadvantages of PET/MRI compared to PET/CT in the oncological setting. There was evidence to support the use of FDG PET/MRI in staging of nasopharyngeal cancer and high-risk BC. Preliminary data indicate the superiority of PET/MRI for the detection of local recurrence in PC, local tumour invasion in cervical cancer, and liver metastases in colorectal cancer. These conclusions are based on small datasets and need to be further explored.

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Title: Hybrid PET/MRI in major cancers: a scoping review
Authors: Anni Morsing
Malene Grubbe Hildebrandt
Mie Holm Vilstrup
Sara Elisabeth Wallenius
Oke Gerke
Henrik Petersen
Allan Johansen
Thomas Lund Andersen
Poul Flemming Høilund-Carlsen
Publication date: 01-09-2019
Publisher: Springer Berlin Heidelberg
Keywords: Metastasis
Prostate Cancer
Prostate Cancer
Breast Cancer
Breast Cancer
Published in: European Journal of Nuclear Medicine and Molecular Imaging / Issue 10/2019
Print ISSN: 1619-7070
Electronic ISSN: 1619-7089
DOI: https://doi.org/10.1007/s00259-019-04402-8

At a glance: The STEP trials

Springer Medicine

Hybrid PET/MRI in major cancers: a scoping review

Abstract

Purpose

Methods

Results

Conclusion

At a glance: The STEP trials

Springer Medicine

Abstract

Purpose

Methods

Results

Conclusion

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