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European Journal of Nuclear Medicine and Molecular Imaging
Published in: European Journal of Nuclear Medicine and Molecular Imaging 3/2017

Open Access 01-03-2017 | Original Article

The prognostic value of FET PET at radiotherapy planning in newly diagnosed glioblastoma

Authors: Sidsel Højklint Poulsen, Thomas Urup, Kirsten Grunnet, Ib Jarle Christensen, Vibeke Andrée Larsen, Michael Lundemann Jensen, Per Munck af Rosenschöld, Hans Skovgaard Poulsen, Ian Law

Published in: European Journal of Nuclear Medicine and Molecular Imaging | Issue 3/2017

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Abstract

Background

Glioblastoma patients show a great variability in progression free survival (PFS) and overall survival (OS). To gain additional pretherapeutic information, we explored the potential of O-(2-18F-fluoroethyl)-L-tyrosine (FET) PET as an independent prognostic biomarker.

Methods

We retrospectively analyzed 146 consecutively treated, newly diagnosed glioblastoma patients. All patients were treated with temozolomide and radiation therapy (RT). CT/MR and FET PET scans were obtained postoperatively for RT planning. We used Cox proportional hazards models with OS and PFS as endpoints, to test the prognostic value of FET PET biological tumor volume (BTV).

Results

Median follow-up time was 14 months, and median OS and PFS were 16.5 and 6.5 months, respectively. In the multivariate analysis, increasing BTV (HR = 1.17, P < 0.001), poor performance status (HR = 2.35, P < 0.001), O(6)-methylguanine-DNA methyltransferase protein status (HR = 1.61, P = 0.024) and higher age (HR = 1.32, P = 0.013) were independent prognostic factors of poor OS. For poor PFS, only increasing BTV (HR = 1.18; P = 0.002) was prognostic. A prognostic index for OS was created based on the identified prognostic factors.

Conclusion

Large BTV on FET PET is an independent prognostic factor of poor OS and PFS in glioblastoma patients. With the introduction of FET PET, we obtain a prognostic index that can help in glioblastoma treatment planning.
Appendix
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Metadata
Title
The prognostic value of FET PET at radiotherapy planning in newly diagnosed glioblastoma
Authors
Sidsel Højklint Poulsen
Thomas Urup
Kirsten Grunnet
Ib Jarle Christensen
Vibeke Andrée Larsen
Michael Lundemann Jensen
Per Munck af Rosenschöld
Hans Skovgaard Poulsen
Ian Law
Publication date
01-03-2017
Publisher
Springer Berlin Heidelberg
Published in
European Journal of Nuclear Medicine and Molecular Imaging / Issue 3/2017
Print ISSN: 1619-7070
Electronic ISSN: 1619-7089
DOI
https://doi.org/10.1007/s00259-016-3494-2

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