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European Journal of Nuclear Medicine and Molecular Imaging

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01-12-2016 | Image of the Month

HIV encephalitis with subcortical tau deposition: imaging pathology in vivo using F-18 THK 5117

Authors: Madhavi Tripathi, Saroj Yadav, Vivek Kumar, Rajeev Kumar, Manjari Tripathi, Shailesh Gaikwad, Parveen Kumar, Chandrasekhar Bal

Published in: European Journal of Nuclear Medicine and Molecular Imaging | Issue 13/2016

Excerpt

A 70-year-old widow of 4 years presented with memory complaints for the past 4 months, apraxia, and bladder and bowel incontinence. As a part of an ongoing study the patient underwent both F-18 FDG positron emission tomography (PET) and F-18 THK5117 PET. There was frontal, parietal, and temporal hypometabolism on F-18 FDG PET (a) while F-18 THK 5117 study showed increased TAU binding in the periventricular and deep white matter regions (b). MRI showed hyperintensities in the periventricular and deep white matter (c). The patient was subsequently found to be HIV positive on ELISA with a CD4 count of 124. A working diagnosis of HIV encephalitis (HIVE) was made. …

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Title: HIV encephalitis with subcortical tau deposition: imaging pathology in vivo using F-18 THK 5117
Authors: Madhavi Tripathi
Saroj Yadav
Vivek Kumar
Rajeev Kumar
Manjari Tripathi
Shailesh Gaikwad
Parveen Kumar
Chandrasekhar Bal
Publication date: 01-12-2016
Publisher: Springer Berlin Heidelberg
Published in: European Journal of Nuclear Medicine and Molecular Imaging / Issue 13/2016
Print ISSN: 1619-7070
Electronic ISSN: 1619-7089
DOI: https://doi.org/10.1007/s00259-016-3473-7

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