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European Journal of Nuclear Medicine and Molecular Imaging

Published in:

01-07-2016 | Original Article

Development of a nomogram combining clinical staging with ¹⁸F-FDG PET/CT image features in non-small-cell lung cancer stage I–III

Authors: Marie-Charlotte Desseroit, Dimitris Visvikis, Florent Tixier, Mohamed Majdoub, Rémy Perdrisot, Rémy Guillevin, Catherine Cheze Le Rest, Mathieu Hatt

Published in: European Journal of Nuclear Medicine and Molecular Imaging | Issue 8/2016

Abstract

Purpose

Our goal was to develop a nomogram by exploiting intratumour heterogeneity on CT and PET images from routine ¹⁸F-FDG PET/CT acquisitions to identify patients with the poorest prognosis.

Methods

This retrospective study included 116 patients with NSCLC stage I, II or III and with staging ¹⁸F-FDG PET/CT imaging. Primary tumour volumes were delineated using the FLAB algorithm and 3D Slicer™ on PET and CT images, respectively. PET and CT heterogeneities were quantified using texture analysis. The reproducibility of the CT features was assessed on a separate test–retest dataset. The stratification power of the PET/CT features was evaluated using the Kaplan-Meier method and the log-rank test. The best standard metric (functional volume) was combined with the least redundant and most prognostic PET/CT heterogeneity features to build the nomogram.

Results

PET entropy and CT zone percentage had the highest complementary values with clinical stage and functional volume. The nomogram improved stratification amongst patients with stage II and III disease, allowing identification of patients with the poorest prognosis (clinical stage III, large tumour volume, high PET heterogeneity and low CT heterogeneity).

Conclusion

Intratumour heterogeneity quantified using textural features on both CT and PET images from routine staging ¹⁸F-FDG PET/CT acquisitions can be used to create a nomogram with higher stratification power than staging alone.

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Title: Development of a nomogram combining clinical staging with 18F-FDG PET/CT image features in non-small-cell lung cancer stage I–III
Authors: Marie-Charlotte Desseroit
Dimitris Visvikis
Florent Tixier
Mohamed Majdoub
Rémy Perdrisot
Rémy Guillevin
Catherine Cheze Le Rest
Mathieu Hatt
Publication date: 01-07-2016
Publisher: Springer Berlin Heidelberg
Published in: European Journal of Nuclear Medicine and Molecular Imaging / Issue 8/2016
Print ISSN: 1619-7070
Electronic ISSN: 1619-7089
DOI: https://doi.org/10.1007/s00259-016-3325-5

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Development of a nomogram combining clinical staging with ¹⁸F-FDG PET/CT image features in non-small-cell lung cancer stage I–III

Abstract

Purpose

Methods

Results

Conclusion

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Abstract

Purpose

Methods

Results

Conclusion

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