Skip to main content
Key Specialties
Cardiology Diabetology Endocrinology Gastroenterology Geriatrics and Gerontology Gynecology and Obstetrics Hematology Infectious Disease Internal Medicine Nephrology Neurology Oncology Pediatrics Respiratory Medicine Rheumatology Surgery
Congress Coverage
2024 ACC Congress 2023 ESMO Congress 2023 EASD Congress 2023 ERS Congress 2023 ESC Congress
Clinical Collections
Advances in Alzheimer’s

At a glance: The STEP trials

A round-up of the STEP phase 3 clinical trials evaluating semaglutide for weight loss in people with overweight or obesity.
ADVANCED SEARCH
Log in
Top
European Journal of Nuclear Medicine and Molecular Imaging
Published in: European Journal of Nuclear Medicine and Molecular Imaging 4/2016

01-04-2016 | Original Article

Predictors of ventricular remodelling in patients with reperfused acute myocardial infarction and left ventricular dysfunction candidates for bone marrow cell therapy: insights from the BONAMI trial

Authors: Alain Manrique, Patricia Lemarchand, Béatrice Delasalle, Olivier Lairez, Catherine Sportouch-Duckan, Guillaume Lamirault, Philippe Le Corvoisier, Yannick Neuder, Marjorie Richardson, Alain Lebon, Jérome Roncalli, Christophe Piot, Jean-Noel Trochu, Emmanuel Teiger, Claude Hossein-Foucher, Thierry Le Tourneau

Published in: European Journal of Nuclear Medicine and Molecular Imaging | Issue 4/2016

Login to get access

Abstract

Purpose

Few data are available regarding the relation of left ventricular (LV) mechanical dyssynchrony to remodelling after acute myocardial infarction (MI) and stem cell therapy. We evaluated the 1-year time course of both LV mechanical dyssynchrony and remodelling in patients enrolled in the BONAMI trial, a randomized, multicenter controlled trial assessing cell therapy in patients with reperfused MI.

Methods

Patients with acute MI and ejection fraction (EF) ≤ 45 % were randomized to cell therapy or to control and underwent thallium single-photon emission computed tomography (SPECT), radionuclide angiography, and echocardiography at baseline, 3 months, and 1 year. Eighty-three patients with a comprehensive 1-year follow-up were included. LV dyssynchrony was assessed by the standard deviation (SD) of the LV phase histogram using radionuclide angiography. Remodelling was defined as a 20 % increase in LV end-systolic volume index (LVESVI) at 1 year.

Results

At baseline, LVEF, wall motion score index, and perfusion defect size were significantly impaired in the 43 patients (52 %) with LV remodelling (all p < 0.001), without significant increase in LV mechanical dyssynchrony. During follow-up, there was a progressive increase in LV SD (p = 0.01). Baseline independent predictors of LV remodelling were perfusion SPECT defect size (p = 0.001), LVEF (p = 0.01) and a history of hypertension (p = 0.043). Bone marrow cell therapy did not affect the time-course of LV remodelling and dyssynchrony.

Conclusions

LV remodelling 1 year after reperfused MI is associated with progressive LV dyssynchrony and is related to baseline infarct size and ejection fraction, without impact of cell therapy on this process.
Appendix
Available only for authorised users
Literature
1.
Bolognese L, Neskovic AN, Parodi G, Cerisano G, Buonamici P, Santoro GM, et al. Left ventricular remodeling after primary coronary angioplasty patterns of left ventricular dilation and long-term prognostic implications. Circulation. 2002;106:2351–7.CrossRefPubMed
2.
Parodi G, Memisha G, Carrabba N, Signorini U, Migliorini A, Cerisano G, et al. Prevalence, predictors, time course, and long-term clinical implications of left ventricular functional recovery after mechanical reperfusion for acute myocardial infarction. Am J Cardiol. 2007;100:1718–22.CrossRefPubMed
3.
Nucifora G, Bertini M, Marsan NA, Delgado V, Scholte AJ, Ng ACT, et al. Impact of left ventricular dyssynchrony early on left ventricular function after first acute myocardial infarction. Am J Cardiol. 2010;105:306–11.CrossRefPubMed
4.
Zhang Y, Yip GW, Chan AKY, Wang M, Lam WWM, Fung JWH, et al. Left ventricular systolic dyssynchrony is a predictor of cardiac remodeling after myocardial infarction. Am Heart J. 2008;156:1124–32.CrossRefPubMed
5.
Chang S-A, Chang H-J, Choi SI, Chun EJ, Yoon YE, Kim H-K, et al. Usefulness of left ventricular dyssynchrony after acute myocardial infarction, assessed by a tagging magnetic resonance image derived metric, as a determinant of ventricular remodeling. Am J Cardiol. 2009;104:19–23.CrossRefPubMed
6.
Zimmet H, Porapakkham P, Porapakkham P, Sata Y, Haas SJ, Itescu S, et al. Short- and long-term outcomes of Intracoronary and endogenously mobilized bone marrow stem cells in the treatment of ST-segment elevation myocardial infarction: a meta-analysis of randomized control trials. Eur J Heart Fail. 2012;14:91–105.CrossRefPubMed
7.
Roncalli J, Mouquet F, Piot C, Trochu J-N, Le Corvoisier P, Neuder Y, et al. Intracoronary autologous mononucleated bone marrow cell infusion for acute myocardial infarction: results of the randomized multicenter BONAMI trial. Eur Heart J. 2011;32:1748–57.PubMedCentralCrossRefPubMed
8.
Manrique A, Bernard M, Hitzel A, Bauer F, Ménard J-F, Sabatier R, et al. Prognostic value of sympathetic innervation and cardiac asynchrony in dilated cardiomyopathy. Eur J Nucl Med Mol Imaging. 2008;35:2074–81.CrossRefPubMed
9.
Cerqueira MD, Weissman NJ, Dilsizian V, Jacobs AK, Kaul S, Laskey WK, et al. Standardized myocardial segmentation and nomenclature for tomographic imaging of the heart a statement for healthcare professionals from the cardiac imaging committee of the council on clinical cardiology of the american heart association. Circulation. 2002;105:539–42.CrossRefPubMed
10.
Faraggi M, Karila-Cohen D, Brochet E, Lebtahi R, Czitrom D, Feldman LJ, et al. Relationship between resting 201Tl reverse redistribution, microvascular perfusion, and functional recovery in acute myocardial infarction. J Nucl Med. 2000;41:393–9.PubMed
11.
Lang RM, Bierig M, Devereux RB, Flachskampf FA, Foster E, Pellikka PA, et al. Recommendations for chamber quantification: a report from the american society of echocardiography’s guidelines and standards committee and the chamber quantification writing group, developed in conjunction with the european association of echocardiography, a branch of the european society of cardiology. J Am Soc Echocardiogr. 2005;18:1440–63.CrossRefPubMed
12.
Sutton MGSJ, Sharpe N. Left ventricular remodeling after myocardial infarction pathophysiology and therapy. Circulation. 2000;101:2981–8.CrossRefPubMed
13.
Lipinski MJ, Biondi-Zoccai GGL, Abbate A, Khianey R, Sheiban I, Bartunek J, et al. Impact of Intracoronary cell therapy on left ventricular function in the setting of acute myocardial infarction: a collaborative systematic review and meta-analysis of controlled clinical trials. J Am Coll Cardiol. 2007;50:1761–7.CrossRefPubMed
14.
Brunskill SJ, Hyde CJ, Doree CJ, Watt SM, Martin-Rendon E. Route of delivery and baseline left ventricular ejection fraction, key factors of bone-marrow-derived cell therapy for ischaemic heart disease. Eur J Heart Fail. 2009;11:887–96.CrossRefPubMed
15.
Zhang S, Sun A, Ge J, Yao K, Huang Z, Wang K, et al. Intracoronary autologous bone marrow stem cells transfer for patients with acute myocardial infarction: a meta-analysis of randomised controlled trials. Int J Cardiol. 2009;136:178–85.CrossRefPubMed
16.
17.
Mollema SA, Liem SS, Suffoletto MS, Bleeker GB, van der Hoeven BL, van de Veire NR, et al. Left ventricular dyssynchrony acutely after myocardial infarction predicts left ventricular remodeling. J Am Coll Cardiol. 2007;50:1532–40.CrossRefPubMed
18.
Giannuzzi P, Temporelli PL, Bosimini E, Gentile F, Lucci D, Maggioni AP, et al. Heterogeneity of left ventricular remodeling after acute myocardial infarction: results of the gruppo italiano per lo studio della sopravvivenza nell’Infarto miocardico-3 echo substudy. Am Heart J. 2001;141:131–8.CrossRefPubMed
19.
White HD, Norris RM, Brown MA, Brandt PW, Whitlock RM, Wild CJ. Left ventricular end-systolic volume as the major determinant of survival after recovery from myocardial infarction. Circulation. 1987;76:44–51.CrossRefPubMed
20.
Pfeffer MA, Braunwald E, Moyé LA, Basta L, Brown EJ, Cuddy TE, et al. Effect of captopril on mortality and morbidity in patients with left ventricular dysfunction after myocardial infarction. N Engl J Med. 1992;327:669–77.CrossRefPubMed
21.
Doughty RN, Whalley GA, Walsh HA, Gamble GD, López-Sendón J, Sharpe N. Effects of carvedilol on left ventricular remodeling after acute myocardial infarction the CAPRICORN echo substudy. Circulation. 2004;109:201–6.CrossRefPubMed
22.
Pitt B, Remme W, Zannad F, Neaton J, Martinez F, Roniker B, et al. Eplerenone, a selective aldosterone blocker, in patients with left ventricular dysfunction after myocardial infarction. N Engl J Med. 2003;348:1309–21.CrossRefPubMed
23.
Parodi G, Antoniucci D. Left ventricular remodeling after primary percutaneous coronary intervention. Am Heart J. 2010;160:S11–5.CrossRefPubMed
24.
Turan B, Yilmaz F, Karaahmet T, Tigen K, Mutlu B, Basaran Y. Role of left ventricular dyssynchrony in predicting remodeling after ST elevation myocardial infarction. Echocardiography. 2012;29:165–72.CrossRefPubMed
25.
Fahmy Elnoamany M, Mahfouz Badran H, Helmy Abo Elazm T, Shawky Abdelaziz E. Asynchrony of left ventricular systolic performance after the first acute myocardial infarction in patients with narrow QRS complexes: doppler tissue imaging study. J Am Soc Echocardiogr. 2006;19:1449–57.CrossRefPubMed
26.
Zhang Y, Chan AKY, Yu C-M, Lam WWM, Yip GWK, Fung W-H, et al. Left ventricular systolic asynchrony after acute myocardial infarction in patients with narrow QRS complexes. Am Heart J. 2005;149:497–503.CrossRefPubMed
27.
Nucifora G, Bertini M, Marsan NA, Scholte AJ, Siebelink H-MJ, Holman ER, et al. Temporal evolution of left ventricular dyssynchrony after myocardial infarction: relation with changes in left ventricular systolic function. Eur Heart J Cardiovasc Imaging. 2012;13(12):1041–6.CrossRefPubMed
28.
Marsan NA, Henneman MM, Chen J, Ypenburg C, Dibbets P, Ghio S, et al. Left ventricular dyssynchrony assessed by two three-dimensional imaging modalities: phase analysis of gated myocardial perfusion SPECT and tri-plane tissue doppler imaging. Eur J Nucl Med Mol Imaging. 2008;35:166–73.CrossRefPubMed
29.
Henneman MM, Chen J, Dibbets-Schneider P, Stokkel MP, Bleeker GB, Ypenburg C, et al. Can LV dyssynchrony as assessed with phase analysis on gated myocardial perfusion SPECT predict response to CRT? J Nucl Med. 2007;48:1104–11.CrossRefPubMed
30.
Miller TD, Christian TF, Hopfenspirger MR, Hodge DO, Gersh BJ, Gibbons RJ. Infarct size after acute myocardial infarction measured by quantitative tomographic 99mTc sestamibi imaging predicts subsequent mortality. Circulation. 1995;92:334–41.CrossRefPubMed
31.
Bolognese L, Cerisano G, Buonamici P, Santini A, Santoro GM, Antoniucci D, et al. Influence of infarct-zone viability on left ventricular remodeling after acute myocardial infarction. Circulation. 1997;96:3353–9.CrossRefPubMed
32.
Lipiecki J, Cachin F, Durel N, de Tauriac O, Ponsonnaille J, Maublant J. Influence of infarct-zone viability detected by rest Tc-99 m sestamibi gated SPECT on left ventricular remodeling after acute myocardial infarction treated by percutaneous transluminal coronary angioplasty in the acute phase. J Nucl Cardiol. 2004;11:673–81.CrossRefPubMed
33.
Berti V, Sciagrà R, Acampa W, Ricci F, Cerisano G, Gallicchio R, et al. Relationship between infarct size and severity measured by gated SPECT and long-term left ventricular remodelling after acute myocardial infarction. Eur J Nucl Med Mol Imaging. 2011;38:1124–31.CrossRefPubMed
34.
Schächinger V, Erbs S, Elsässer A, Haberbosch W, Hambrecht R, Hölschermann H, et al. Intracoronary bone marrow–derived progenitor cells in acute myocardial infarction. N Engl J Med. 2006;355:1210–21.CrossRefPubMed
Metadata
Title
Predictors of ventricular remodelling in patients with reperfused acute myocardial infarction and left ventricular dysfunction candidates for bone marrow cell therapy: insights from the BONAMI trial
Authors
Alain Manrique
Patricia Lemarchand
Béatrice Delasalle
Olivier Lairez
Catherine Sportouch-Duckan
Guillaume Lamirault
Philippe Le Corvoisier
Yannick Neuder
Marjorie Richardson
Alain Lebon
Jérome Roncalli
Christophe Piot
Jean-Noel Trochu
Emmanuel Teiger
Claude Hossein-Foucher
Thierry Le Tourneau
Publication date
01-04-2016
Publisher
Springer Berlin Heidelberg
Published in
European Journal of Nuclear Medicine and Molecular Imaging / Issue 4/2016
Print ISSN: 1619-7070
Electronic ISSN: 1619-7089
DOI
https://doi.org/10.1007/s00259-015-3279-z

Other articles of this Issue 4/2016

European Journal of Nuclear Medicine and Molecular Imaging 4/2016 Go to the issue

Image of the Month

68Ga-PSMA PET/CT imaging in primary hepatocellular carcinoma

Society Communications

2015 Young Investigators Meeting

Original Article

Relationship between left ventricular diastolic function and myocardial sympathetic denervation measured by 123I-meta-iodobenzylguanidine imaging in Anderson-Fabry disease

Original Article

Symptomatic versus asymptomatic knees after bilateral total knee arthroplasty: what is the difference in SPECT/CT?

Image of the Month

Vulnerable plaque on the common iliac artery detected by 18F-FDG PET/MRI

Original Article

Quantitative and qualitative analysis of [18F]FDG and [18F]FAZA positron emission tomography of head and neck cancers and associations with HPV status and treatment outcome