Top

European Journal of Nuclear Medicine and Molecular Imaging

Published in:

01-01-2016 | Image of the Month

Intense PSMA-expression using ⁶⁸Ga-PSMA PET/CT in a paravertebral schwannoma mimicking prostate cancer metastasis

Authors: Christoph Rischpler, Tobias Maurer, Markus Schwaiger, Matthias Eiber

Published in: European Journal of Nuclear Medicine and Molecular Imaging | Issue 1/2016

Excerpt

The prostate-specific membrane antigen (PSMA) is highly expressed in prostate cancer (PC) cells. The recently introduced PSMA-PET/CT has evolved as a powerful imaging tool for staging of PC [1‐3]. Albeit the high specificity of PSMA-tracers, there are reports of high PSMA-expression in non-prostatic malignant (e.g., renal cell carcinoma, bronchial carcinoma, and glioblastoma) and benign (schwannomas) lesions [4]. These reports raise concerns over the specificity of PSMA-PET imaging indicating the need for thorough review of accompanying morphological images besides exclusive interpretation of and reliance on PSMA-expression in PET. …

Eiber M, Maurer T, Souvatzoglou M, Beer AJ, Ruffani A, Haller B, et al. Evaluation of Hybrid (6)(8)Ga-PSMA Ligand PET/CT in 248 Patients with Biochemical Recurrence After Radical Prostatectomy. J Nucl Med. 2015;56:668–74.CrossRefPubMed

Afshar-Oromieh A, Avtzi E, Giesel FL, Holland-Letz T, Linhart HG, Eder M, et al. The diagnostic value of PET/CT imaging with the (68)Ga-labelled PSMA ligand HBED-CC in the diagnosis of recurrent prostate cancer. Eur J Nucl Med Mol Imaging. 2015;42:197–209.PubMedCentralCrossRefPubMed

Maurer T, Beer AJ, Wester HJ, Kubler H, Schwaiger M, Eiber M. Positron emission tomography/magnetic resonance imaging with 68Gallium-labeled ligand of prostate-specific membrane antigen: promising novel option in prostate cancer imaging? Int J Urol. 2014;21:1286–8.CrossRefPubMed

Wang W, Tavora F, Sharma R, Eisenberger M, Netto GJ. PSMA expression in Schwannoma: a potential clinical mimicker of metastatic prostate carcinoma. Urol Oncol. 2009;27:525–8.CrossRefPubMed

Wu JS, Hochman MG. Soft-tissue tumors and tumorlike lesions: a systematic imaging approach. Radiology. 2009;253:297–316.CrossRefPubMed

Title: Intense PSMA-expression using 68Ga-PSMA PET/CT in a paravertebral schwannoma mimicking prostate cancer metastasis
Authors: Christoph Rischpler
Tobias Maurer
Markus Schwaiger
Matthias Eiber
Publication date: 01-01-2016
Publisher: Springer Berlin Heidelberg
Published in: European Journal of Nuclear Medicine and Molecular Imaging / Issue 1/2016
Print ISSN: 1619-7070
Electronic ISSN: 1619-7089
DOI: https://doi.org/10.1007/s00259-015-3235-y

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Intense PSMA-expression using ⁶⁸Ga-PSMA PET/CT in a paravertebral schwannoma mimicking prostate cancer metastasis

Excerpt

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Excerpt

Please log in to get access to this content

Other articles of this Issue 1/2016

Of standard of reference and accuracy: the problem of truth in imaging

Quantification of TSPO overexpression in a rat model of local neuroinflammation induced by intracerebral injection of LPS by the use of [18F]DPA-714 PET

Factors affecting 223Ra therapy: clinical experience after 532 cycles from a single institution

Locoregional tumour evaluation of squamous cell carcinoma in the head and neck area: a comparison between MRI, PET/CT and integrated PET/MRI

Utility of the combination of DAT SPECT and MIBG myocardial scintigraphy in differentiating dementia with Lewy bodies from Alzheimer’s disease

Dosimetry for 177Lu-DKFZ-PSMA-617: a new radiopharmaceutical for the treatment of metastatic prostate cancer