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European Journal of Nuclear Medicine and Molecular Imaging

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01-07-2015 | Editorial Commentary

Radioembolization with ⁹⁰Y-loaded microspheres: high clinical impact of treatment simulation with MAA-based dosimetry

Author: Etienne Garin

Published in: European Journal of Nuclear Medicine and Molecular Imaging | Issue 8/2015

Excerpt

Radioembolization with ⁹⁰Y-loaded glass or resin microspheres is being increasingly used in the treatment of primary and secondary liver cancers. However, no randomized phase III studies have so far been conducted providing proof of this technique’s effectiveness. In colorectal metastatic disease refractory to chemotherapy, its efficacy has been proven by two randomized studies using ⁹⁰Y-loaded resin microspheres [1, 2]. In hepatocellular carcinoma (HCC), the efficacy of radioembolization in patients with portal vein thrombosis (PVT) was demonstrated a long time ago using ¹³¹I-Lipiodol [3], and the results of this large patient cohort are encouraging [4, 5]. …

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Hendlisz A, Van den Eynde M, Peeters M, Maleux G, Lambert B, Vannoote J, et al. Phase III trial comparing protracted intravenous fluorouracil infusion alone or with yttrium-90 resin microspheres radioembolization for liver-limited metastatic colorectal cancer refractory to standard chemotherapy. J Clin Oncol 2010;28(23):3687–94.PubMedCrossRef

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Garin E, Lenoir L, Edeline J, Laffont S, Mesbah H, Porée P, et al. Boosted selective internal radiation therapy with 90Y-loaded glass microspheres (B-SIRT) for hepatocellular carcinoma patients: a new personalized promising concept. Eur J Nucl Med Mol Imaging 2013;40(7):1057–68.PubMedCentralPubMedCrossRef

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Dhabuwala A, Lamerton P, Stubbs RS. Relationship of 99mtechnetium labelled macroaggregated albumin (99mTc-MAA) uptake by colorectal liver metastases to response following selective internal radiation therapy (SIRT). BMC Nucl Med 2005;23:5–7.

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Ulrich G, Dudeck O, Furth C, Ruf J, Grosser OS, Adolf D, et al. Predictive value of intratumoral 99mTc-macroaggregated albumin uptake in patients with colorectal liver metastases scheduled for radioembolization with 90Y-microspheres. J Nucl Med 2013;54(4):516–22.PubMedCrossRef

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Garin E, Rolland Y, Edeline J, Icard N, Lenoir L, Laffont S, et al. Personalized dosimetry and intensification concept with 90Y-loaded glass microsphere radioembolization induces prolonged overall survival in hepatocellular carcinoma patients with portal vein thrombosis. J Nucl Med 2015;56(3):339–46.PubMedCrossRef

Title: Radioembolization with 90Y-loaded microspheres: high clinical impact of treatment simulation with MAA-based dosimetry
Author: Etienne Garin
Publication date: 01-07-2015
Publisher: Springer Berlin Heidelberg
Published in: European Journal of Nuclear Medicine and Molecular Imaging / Issue 8/2015
Print ISSN: 1619-7070
Electronic ISSN: 1619-7089
DOI: https://doi.org/10.1007/s00259-015-3073-y

At a glance: The STEP trials

Springer Medicine

Radioembolization with ⁹⁰Y-loaded microspheres: high clinical impact of treatment simulation with MAA-based dosimetry

Excerpt

At a glance: The STEP trials

Springer Medicine

Excerpt

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