Top

European Journal of Nuclear Medicine and Molecular Imaging

Published in:

01-09-2015 | Image of the Month

First evidence of PSMA expression in differentiated thyroid cancer using [⁶⁸Ga]PSMA-HBED-CC PET/CT

Authors: Frederik A. Verburg, Thomas Krohn, Alexander Heinzel, Felix M. Mottaghy, Florian F. Behrendt

Published in: European Journal of Nuclear Medicine and Molecular Imaging | Issue 10/2015

Excerpt

The prostate-specific membrane antigen (PSMA) has recently emerged as a target for radionuclide imaging and therapy of prostate cancer [1, 2]. However, PSMA expression was also shown on the cell membrane of endothelial cells of tumour neovasculature in a number of other cancers such as renal cell carcinoma [3, 4], colon carcinoma, neuroendocrine tumours, melanoma or breast cancer [3]. However, to our knowledge no study has yet investigated the expression of PSMA in the neovasculature of differentiated thyroid cancer (DTC). …

Afshar-Oromieh A, Avtzi E, Giesel FL, Holland-Letz T, Linhart HG, Eder M, et al. The diagnostic value of PET/CT imaging with the (68)Ga-labelled PSMA ligand HBED-CC in the diagnosis of recurrent prostate cancer. Eur J Nucl Med Mol Imaging 2015;42:197–209.PubMedCentralPubMedCrossRef

Kratochwil C, Giesel FL, Eder M, Afshar-Oromieh A, Benešová M, Mier W, Kopka K, Haberkorn U. [(177)Lu]Lutetium-labelled PSMA ligand-induced remission in a patient with metastatic prostate cancer. Eur J Nucl Med Mol Imaging 2015;42:987–8.

Chang SS, Reuter VE, Heston WD, Bander NH, Grauer LS, Gaudin PB. Five different anti-prostate-specific membrane antigen (PSMA) antibodies confirm PSMA expression in tumor-associated neovasculature. Cancer Res 1999;59:3192–8.PubMed

Demirci E, Ocak M, Kabasakal L, Decristoforo C, Talat Z, Halaç M, et al. (68)Ga-PSMA PET/CT imaging of metastatic clear cell renal cell carcinoma. Eur J Nucl Med Mol Imaging 2014;41:1461–2.PubMedCrossRef

Luster M, Weber T, Verburg FA. Differentiated thyroid cancer-personalized therapies to prevent overtreatment. Nat Rev Endocrinol 2014;10:563–74.PubMedCrossRef

Title: First evidence of PSMA expression in differentiated thyroid cancer using [68Ga]PSMA-HBED-CC PET/CT
Authors: Frederik A. Verburg
Thomas Krohn
Alexander Heinzel
Felix M. Mottaghy
Florian F. Behrendt
Publication date: 01-09-2015
Publisher: Springer Berlin Heidelberg
Published in: European Journal of Nuclear Medicine and Molecular Imaging / Issue 10/2015
Print ISSN: 1619-7070
Electronic ISSN: 1619-7089
DOI: https://doi.org/10.1007/s00259-015-3065-y

At a glance: The STEP trials

Springer Medicine

First evidence of PSMA expression in differentiated thyroid cancer using [⁶⁸Ga]PSMA-HBED-CC PET/CT

Excerpt

At a glance: The STEP trials

Springer Medicine

Excerpt

Please log in to get access to this content

Other articles of this Issue 10/2015

Test–retest repeatability of myocardial blood flow and infarct size using 11C-acetate micro-PET imaging in mice

β-Amyloid binding in elderly subjects with declining or stable episodic memory function measured with PET and [11C]AZD2184

Very high coronary artery calcium score with normal myocardial perfusion SPECT imaging is associated with a moderate incidence of severe coronary artery disease

Amyloid PET in European and North American cohorts; and exploring age as a limit to clinical use of amyloid imaging

Test–retest reproducibility of the metabotropic glutamate receptor 5 ligand [18F]FPEB with bolus plus constant infusion in humans

Frank Rösch: Nuclear and Radiochemistry, Volume 1: Introduction