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European Journal of Nuclear Medicine and Molecular Imaging

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01-04-2013 | Review Article

Value of ¹¹C-methionine PET in imaging brain tumours and metastases

Authors: Andor W. J. M. Glaudemans, Roelien H. Enting, Mart A. A. M. Heesters, Rudi A. J. O. Dierckx, Ronald W. J. van Rheenen, Annemiek M. E. Walenkamp, Riemer H. J. A. Slart

Published in: European Journal of Nuclear Medicine and Molecular Imaging | Issue 4/2013

Abstract

¹¹C-methionine (MET) is the most popular amino acid tracer used in PET imaging of brain tumours. Because of its characteristics, MET PET provides a high detection rate of brain tumours and good lesion delineation. This review focuses on the role of MET PET in imaging cerebral gliomas. The Introduction provides a clinical overview of what is important in primary brain tumours, recurrent brain tumours and brain metastases. The indications for radiotherapy and the results and problems arising after chemoradiotherapy in relation to imaging (pseudoprogression or radionecrosis) are discussed. The working mechanism, scan interpretation and quantification possibilities of MET PET are then explained. A literature overview is given of the role of MET PET in primary gliomas (diagnostic accuracy, grading, prognosis, assessment of tumour extent, biopsy and radiotherapy planning), in brain metastases, and in the differentiation between tumour recurrence and radiation necrosis. Finally, MET PET is compared to other nuclear imaging possibilities in brain tumour imaging.

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Title: Value of 11C-methionine PET in imaging brain tumours and metastases
Authors: Andor W. J. M. Glaudemans
Roelien H. Enting
Mart A. A. M. Heesters
Rudi A. J. O. Dierckx
Ronald W. J. van Rheenen
Annemiek M. E. Walenkamp
Riemer H. J. A. Slart
Publication date: 01-04-2013
Publisher: Springer-Verlag
Published in: European Journal of Nuclear Medicine and Molecular Imaging / Issue 4/2013
Print ISSN: 1619-7070
Electronic ISSN: 1619-7089
DOI: https://doi.org/10.1007/s00259-012-2295-5

At a glance: The STEP trials

Springer Medicine

Value of ¹¹C-methionine PET in imaging brain tumours and metastases

Abstract

At a glance: The STEP trials

Springer Medicine

Abstract

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