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European Journal of Nuclear Medicine and Molecular Imaging

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Open Access 01-09-2012 | Editorial

Can animal data predict human outcome? Problems and pitfalls of translational animal research

Authors: Marianne I. Martić-Kehl, Roger Schibli, P. August Schubiger

Published in: European Journal of Nuclear Medicine and Molecular Imaging | Issue 9/2012

Excerpt

Animal models are believed to be predictive for drug development in human health care. While LD₅₀ studies of drug candidates have always been performed in animals like rodents or dogs, efficacy and adverse effect studies using animals as a model for humans were prompted only in the late 1950s, as a consequence of the thalidomide scandal, where thousands of babies were born with severe extremity deformations. …

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Title: Can animal data predict human outcome? Problems and pitfalls of translational animal research
Authors: Marianne I. Martić-Kehl
Roger Schibli
P. August Schubiger
Publication date: 01-09-2012
Publisher: Springer-Verlag
Published in: European Journal of Nuclear Medicine and Molecular Imaging / Issue 9/2012
Print ISSN: 1619-7070
Electronic ISSN: 1619-7089
DOI: https://doi.org/10.1007/s00259-012-2175-z

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Can animal data predict human outcome? Problems and pitfalls of translational animal research

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