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European Journal of Nuclear Medicine and Molecular Imaging
Published in: European Journal of Nuclear Medicine and Molecular Imaging 1/2012

01-02-2012 | Review Article

Feasibility and availability of 68Ga-labelled peptides

Authors: Clemens Decristoforo, Roger D. Pickett, Alfons Verbruggen

Published in: European Journal of Nuclear Medicine and Molecular Imaging | Special Issue 1/2012

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Abstract

68Ga has attracted tremendous interest as a radionuclide for PET based on its suitable half-life of 68 min, high positron emission yield and ready availability from 68Ge/68Ga generators, making it independent of cyclotron production. 68Ga-labelled DOTA-conjugated somatostatin analogues, including DOTA-TOC, DOTA-TATE and DOTA-NOC, have driven the development of technologies to provide such radiopharmaceuticals for clinical applications mainly in the diagnosis of somatostatin receptor-expressing tumours. We summarize the issues determining the feasibility and availability of 68Ga-labelled peptides, including generator technology, 68Ga generator eluate postprocessing methods, radiolabelling, automation and peptide developments, and also quality assurance and regulatory aspects. 68Ge/68Ga generators based on SnO2, TiO2 or organic matrices are today routinely supplied to nuclear medicine departments, and a variety of automated systems for postprocessing and radiolabelling have been developed. New developments include improved chelators for 68Ga that could open new ways to utilize this technology. Challenges and limitations in the on-site preparation and use of 68Ga-labelled peptides outside the marketing authorization track are also discussed.
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Metadata
Title
Feasibility and availability of 68Ga-labelled peptides
Authors
Clemens Decristoforo
Roger D. Pickett
Alfons Verbruggen
Publication date
01-02-2012
Publisher
Springer-Verlag
Published in
European Journal of Nuclear Medicine and Molecular Imaging / Issue Special Issue 1/2012
Print ISSN: 1619-7070
Electronic ISSN: 1619-7089
DOI
https://doi.org/10.1007/s00259-011-1988-5

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