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European Journal of Nuclear Medicine and Molecular Imaging
Published in: European Journal of Nuclear Medicine and Molecular Imaging 2/2012

01-02-2012 | Image of the Month

Voriconazole-induced periostitis

Authors: Christine Rossier, Vincent Dunet, Frederic Tissot, Berengère Aubry-Rozier, Olivier Marchetti, Ariane Boubaker

Published in: European Journal of Nuclear Medicine and Molecular Imaging | Issue 2/2012

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Excerpt

We report the case of a 42-year-old woman receiving voriconazole for a fungal endophthalmitis, who presented with diffuse and severe musculoskeletal pain after 4 months of therapy. In the absence of an obvious aetiology, the patient was referred for three-phase bone scintigraphy. The anterior whole-body scan acquired 20 min after injection showed multiple and intense linear-shaped foci throughout the skeleton affecting predominantly the diaphyses of the long bones (a), corresponding to increased tracer uptake in the cortical bone on the delayed anterior whole-body scan affecting the upper and lower limbs, clavicles, scapulas and ribs (b, c). …
Literature
1.
Wermers RA, Cooper K, Razonable RR, Deziel PJ, Whitford GM, Kremers WK, et al. Fluoride excess and periostitis in transplant patients receiving long-term voriconazole therapy. Clin Infect Dis. 2011;52:604–11.PubMedCrossRef
2.
Wang TF, Wang T, Altman R, Eshaghian P, Lynch JP 3rd, Ross DJ, et al. Periostitis secondary to prolonged voriconazole therapy in lung transplant recipients. Am J Transplant. 2009;9:2845–50.PubMedCrossRef
3.
Martinez-Lavin M, Pineda C. Hypertrophic osteoarthropathy. In: Hochberg MC, Silman AJ, Smolen JS, Weinblatt ME, Weisman MH, editors. Rheumatology. London: Mosby; 2003. p. 1763.
Metadata
Title
Voriconazole-induced periostitis
Authors
Christine Rossier
Vincent Dunet
Frederic Tissot
Berengère Aubry-Rozier
Olivier Marchetti
Ariane Boubaker
Publication date
01-02-2012
Publisher
Springer-Verlag
Published in
European Journal of Nuclear Medicine and Molecular Imaging / Issue 2/2012
Print ISSN: 1619-7070
Electronic ISSN: 1619-7089
DOI
https://doi.org/10.1007/s00259-011-1922-x

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