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European Journal of Nuclear Medicine and Molecular Imaging

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01-11-2009 | Image of the Month

Monitoring of systemic candidiasis by 18F-FDG PET/CT

Authors: John Avet Jr., Denise Granjon, Nathalie Prevot-Bitot, Vanina Isnardi, Claire Berger, Jean Louis Stephan, Francis Dubois

Published in: European Journal of Nuclear Medicine and Molecular Imaging | Issue 11/2009

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A 16-year-old patient was treated for leukemia and after chemotherapy developed fever, myalgia, myocardial dysfunction, and athralgia. Blood culture showed Candida tropicalis. Contrast-enhanced computed tomography showed multiple kidney and spleen abscesses. After antifungal therapy (TRIFLUCAN) and before restarting chemotherapy, ¹⁸F-FDG PET/CT was performed [1], which demonstrated multiple high metabolic activity lesions in the spleen and kidneys, and unknown disseminated lesions in muscles, myocardium, the right lung, and liver [2, 3]. Bone-marrow-increased metabolic activity seems to be related to the recent chemotherapy treatment. Clinical and ¹⁸F-FDG PET/CT evolution was successful after a new antifungal therapy (NOXAFIL). …

O’Doherty MJ, Barrington SF, Klein JL. Opportunistic infection and nuclear medicine. Semin Nucl Med. 2009;39(2):88–102.CrossRefPubMed

Bleeker-Rovers CP, Vos FJ, Wanten GJ, van der Meer JW, Corstens FH, Kullberg BJ, et al. FDG PET in detecting metastatic infectious disease. J Nucl Med. 2005;46(12):2014–9.PubMed

Zhuang H, Yu JQ, Alavi A. Applications of FDG PET imaging in detection of infection and inflammation and other benign disorders. Radiol Clin North Am. 2005;43(1):121–34.CrossRefPubMed

Bleeker-Rovers CP, Warris A, Drenth JP, Cortens FH, Oven WJ, Kullberg BJ. Diagnosis of Candida lung abscesses by 18F-fluorodeoxyglucose positron emission tomography. Clin Microbiol Infect. 2005;11(6):493–5.CrossRefPubMed

Title: Monitoring of systemic candidiasis by 18F-FDG PET/CT
Authors: John Avet Jr.
Denise Granjon
Nathalie Prevot-Bitot
Vanina Isnardi
Claire Berger
Jean Louis Stephan
Francis Dubois
Publication date: 01-11-2009
Publisher: Springer-Verlag
Published in: European Journal of Nuclear Medicine and Molecular Imaging / Issue 11/2009
Print ISSN: 1619-7070
Electronic ISSN: 1619-7089
DOI: https://doi.org/10.1007/s00259-009-1255-1

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Monitoring of systemic candidiasis by 18F-FDG PET/CT

Excerpt

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