Skip to main content
Key Specialties
Cardiology Diabetology Endocrinology Gastroenterology Geriatrics and Gerontology Gynecology and Obstetrics Hematology Infectious Disease Internal Medicine Nephrology Neurology Oncology Pediatrics Respiratory Medicine Rheumatology Surgery
Congress Coverage
2024 ACC Congress 2023 ESMO Congress 2023 EASD Congress 2023 ERS Congress 2023 ESC Congress
Clinical Collections
Advances in Alzheimer’s

At a glance: The STEP trials

A round-up of the STEP phase 3 clinical trials evaluating semaglutide for weight loss in people with overweight or obesity.
ADVANCED SEARCH
Log in
Top
European Journal of Nuclear Medicine and Molecular Imaging
Published in: European Journal of Nuclear Medicine and Molecular Imaging 11/2009

01-11-2009 | Short Communication

Comparative evaluations of norepinephrine transporter radioligands with reference tissue models in rhesus monkeys: (S,S)-[18F]FMeNER-D2 and (S,S)-[11C]MeNER

Authors: Akihiro Takano, Balázs Gulyás, Andrea Varrone, Christer Halldin

Published in: European Journal of Nuclear Medicine and Molecular Imaging | Issue 11/2009

Login to get access

Abstract

Purpose

Although two norepinephrine transporter (NET) radioligands, (S,S)-[18F]FMeNER-D2 and (S,S)-[11C]MeNER, have been reported to have different characteristics, there has not been a direct comparative study in vivo.

Methods

In this preliminary study, two rhesus monkeys underwent three PET measurements each, one with (S,S)-[18F]FMeNER-D2 and two with different radioactivity of (S,S)-[11C]MeNER (360 and 175 MBq). The regional brain uptakes and BPND values from reference tissue models with different time lengths were compared.

Results

The regional uptakes in the thalamus and the brainstem with (S,S)-[11C]MeNER did not always reach the peak during 123-min measurements while those with (S,S)-[18F]FMeNER-D2 reached the peak before 30 min. The regional BPND values of (S,S)-[18F]FMeNER-D2 were stable after 150-min measurement lengths while those of (S,S)-[11C]MeNER were not stable during 123-min measurements.

Conclusion

(S,S)-[18F]FMeNER-D2 appears to be superior for the quantitative analysis with reference tissue models in the rhesus monkey.
Literature
1.
Schou M, Halldin C, Sóvágó J, Pike VW, Gulyás B, Mozley PD, et al. Specific in vivo binding to the norepinephrine transporter demonstrated with the PET radioligand, (S,S)-[11C]MeNER. Nucl Med Biol 2003;30:707–14.CrossRefPubMed
2.
Ding YS, Lin KS, Garza V, Carter P, Alexoff D, Logan J, et al. Evaluation of a new norepinephrine transporter PET ligand in baboons, both in brain and peripheral organs. Synapse 2003;50:345–52.CrossRefPubMed
3.
Schou M, Halldin C, Sóvágó J, Pike VW, Hall H, Gulyás B, et al. PET evaluation of novel radiofluorinated reboxetine analogs as norepinephrine transporter probes in the monkey brain. Synapse 2004;53:57–67.CrossRefPubMed
4.
Logan J, Wang GJ, Telang F, Fowler JS, Alexoff D, Zabroski J, et al. Imaging the norepinephrine transporter in humans with (S,S)-[11C]O-methyl reboxetine and PET: problems and progress. Nucl Med Biol 2007;34:667–79.CrossRefPubMed
5.
Seneca N, Gulyás B, Varrone A, Schou M, Airaksinen A, Tauscher J, et al. Atomoxetine occupies the norepinephrine transporter in a dose-dependent fashion: a PET study in nonhuman primate brain using (S,S)-[18F]FMeNER-D2. Psychopharmacology (Berl) 2006;188:119–27.CrossRef
6.
Varrone A, Sjöholm N, Eriksson L, Gulyás B, Halldin C, Farde L. Advancement in PET quantification using 3D-OP-OSEM point spread function reconstruction with the HRRT. Eur J Nucl Med Mol Imaging 2009; in press.
7.
Takano A, Gulyás B, Varrone A, Maguire RP, Halldin C. Saturated norepinephrine transporter occupancy by atomoxetine relevant to clinical doses: a rhesus monkey study with (S,S)-[18F]FMeNER-D2. Eur J Nucl Med Mol Imaging 2009; in press.
8.
Lammertsma AA, Hume SP. Simplified reference tissue model for PET receptor studies. Neuroimage 1996;4:153–8.CrossRefPubMed
9.
Ichise M, Liow JS, Lu JQ, Takano A, Model K, Toyama H, et al. Linearized reference tissue parametric imaging methods: application to [11C]DASB positron emission tomography studies of the serotonin transporter in human brain. J Cereb Blood Flow Metab 2003;23:1096–112.CrossRefPubMed
10.
Logan J, Fowler JS, Volkow ND, Wang GJ, Ding YS, Alexoff DL. Distribution volume ratios without blood sampling from graphical analysis of PET data. J Cereb Blood Flow Metab 1996;16:834–40.CrossRefPubMed
Metadata
Title
Comparative evaluations of norepinephrine transporter radioligands with reference tissue models in rhesus monkeys: (S,S)-[18F]FMeNER-D2 and (S,S)-[11C]MeNER
Authors
Akihiro Takano
Balázs Gulyás
Andrea Varrone
Christer Halldin
Publication date
01-11-2009
Publisher
Springer-Verlag
Published in
European Journal of Nuclear Medicine and Molecular Imaging / Issue 11/2009
Print ISSN: 1619-7070
Electronic ISSN: 1619-7089
DOI
https://doi.org/10.1007/s00259-009-1194-x

Other articles of this Issue 11/2009

European Journal of Nuclear Medicine and Molecular Imaging 11/2009 Go to the issue

Image of the Month

Intractable hiccups causing avid FDG uptake in the muscles of respiration

Original Article

Detection of bone metastases in patients with lung cancer: 99mTc-MDP planar bone scintigraphy, 18F-fluoride PET or 18F-FDG PET/CT

Editorial

Diagnostic pathway of integrated SPECT/CT for coronary artery disease

Original Article

Absorbed dose and biologically effective dose in patients with high-risk non-Hodgkin’s lymphoma treated with high-activity myeloablative 90Y-ibritumomab tiuxetan (Zevalin®)

Guidelines

Joint practice guidelines for radionuclide lymphoscintigraphy for sentinel node localization in oral/oropharyngeal squamous cell carcinoma

Original Article

99mTcO(MAG2-3G3-dimer): a new integrin αvβ3-targeted SPECT radiotracer with high tumor uptake and favorable pharmacokinetics