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European Journal of Nuclear Medicine and Molecular Imaging

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01-03-2009 | Short Communication

¹¹C-Acetate PET imaging for renal cell carcinoma

Authors: Nobuyuki Oyama, Hidehiko Okazawa, Naoya Kusukawa, Taisei Kaneda, Yoshiji Miwa, Hironobu Akino, Yasuhisa Fujibayashi, Yoshiharu Yonekura, Michael J. Welch, Osamu Yokoyama

Published in: European Journal of Nuclear Medicine and Molecular Imaging | Issue 3/2009

Abstract

Purpose

In this study, we investigated the effectiveness of positron emission tomography (PET) with ¹¹C-acetate (AC) for evaluation of renal cell carcinoma.

Methods

Enrolled in the study were 20 patients with suspected renal tumour, one of whom had three renal lesions. In all, 22 renal lesions were evaluated. Following administration of 350 MBq (10 mCi) of AC, whole-body PET images were obtained. Based on these PET findings, kidney lesions were scored as positive or negative. The PET results were correlated with the CT findings and histological diagnosis after surgery.

Results

In 18 patients, 20 tumours were diagnosed as renal cell carcinoma. Lesions in the remaining two patients were diagnosed as complicated cyst without malignant tissue. Of the 20 renal cell carcinomas. 14 (70%) showed positive AC PET findings; 6 were negative. The two patients with complicated cyst had negative AC PET findings. Of the 20 renal cell carcinomas, 19 were clear-cell carcinoma and 1 was a papillary cell carcinoma. This papillary cell carcinoma showed high AC uptake.

Conclusion

AC demonstrates marked uptake in renal cell carcinoma. These preliminary data show that AC is a possible PET tracer for detection of renal cancer.

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Title: 11C-Acetate PET imaging for renal cell carcinoma
Authors: Nobuyuki Oyama
Hidehiko Okazawa
Naoya Kusukawa
Taisei Kaneda
Yoshiji Miwa
Hironobu Akino
Yasuhisa Fujibayashi
Yoshiharu Yonekura
Michael J. Welch
Osamu Yokoyama
Publication date: 01-03-2009
Publisher: Springer-Verlag
Published in: European Journal of Nuclear Medicine and Molecular Imaging / Issue 3/2009
Print ISSN: 1619-7070
Electronic ISSN: 1619-7089
DOI: https://doi.org/10.1007/s00259-008-0981-0

At a glance: The STEP trials

Springer Medicine

¹¹C-Acetate PET imaging for renal cell carcinoma

Abstract

Purpose

Methods

Results

Conclusion

At a glance: The STEP trials

Springer Medicine

Abstract

Purpose

Methods

Results

Conclusion

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