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European Journal of Nuclear Medicine and Molecular Imaging
Published in: European Journal of Nuclear Medicine and Molecular Imaging 9/2007

01-09-2007 | Original Article

Fully automatic differential diagnosis system for dementia with Lewy bodies and Alzheimer’s disease using FDG-PET and 3D-SSP

Authors: Atsushi K. Kono, Kazunari Ishii, Keitaro Sofue, Naokazu Miyamoto, Setsu Sakamoto, Etsuro Mori

Published in: European Journal of Nuclear Medicine and Molecular Imaging | Issue 9/2007

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Abstract

Purpose

To evaluate a fully automatic computer-assisted diagnostic system for mild dementia with Lewy bodies (DLB), permitting distinction from mild Alzheimer’s disease (AD).

Methods

Using 18F-fluorodeoxyglucose and positron emission tomography (FDG-PET), glucose metabolic images were obtained from mild DLB and mild AD patients. Two groups consisting of 16 mild DLB patients and 21 mild AD patients were recruited for diagnostic evaluation between mild DLB and mild AD. The mean age ± SD of the mild DLB group and the mild AD group was 74.3 ± 4.9 and 71.7 ± 2.1 years, respectively, and the mean scores of the MMSE for the mild DLB and the mild AD group were 21.7 ± 1.9 and 23.1 ± 2.1, respectively. A receiver operating characteristic (ROC) analysis was performed to compare the diagnostic performance, in terms of discrimination between DLB and AD, of conventional axial FDG-PET images inspected visually by experts and beginners with that of our fully automatic diagnosis system using the statistical brain mapping method and Z scores obtained with the DLB template.

Results

The diagnostic performance of the automatic system was comparable to that of visual inspection by experts. The area under the ROC curve for the automatic diagnosis system was 0.77. The mean area under the ROC curve for visual inspection by experts and beginners was 0.76 and 0.65, respectively.

Conclusion

The fully automatic differential diagnosis system for distinction between mild DLB and AD showed a similar diagnostic accuracy to visual inspection by experts. It would be a useful diagnostic tool to distinguish mild DLB from mild AD in clinical practice.
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Metadata
Title
Fully automatic differential diagnosis system for dementia with Lewy bodies and Alzheimer’s disease using FDG-PET and 3D-SSP
Authors
Atsushi K. Kono
Kazunari Ishii
Keitaro Sofue
Naokazu Miyamoto
Setsu Sakamoto
Etsuro Mori
Publication date
01-09-2007
Publisher
Springer-Verlag
Published in
European Journal of Nuclear Medicine and Molecular Imaging / Issue 9/2007
Print ISSN: 1619-7070
Electronic ISSN: 1619-7089
DOI
https://doi.org/10.1007/s00259-007-0380-y

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