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European Journal of Nuclear Medicine and Molecular Imaging

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Open Access 01-09-2007 | Original Article

Accuracy of 3D acquisition mode for myocardial FDG PET studies using a BGO-based scanner

Authors: Arno P. van der Weerdt, Ronald Boellaard, Frans C. Visser, Adriaan A. Lammertsma

Published in: European Journal of Nuclear Medicine and Molecular Imaging | Issue 9/2007

Abstract

Purpose

The aim of the present study was to evaluate the quantitative and qualitative accuracy of 3D PET acquisitions for myocardial FDG studies.

Methods

Phantom studies were performed with both a homogeneous and an inhomogeneous phantom. Activity profiles were generated along the phantoms using 2D and several 3D reconstructions, varying the 3D scaling value to adjust the scatter correction algorithm. Furthermore, ten patients underwent a dynamic myocardial FDG PET scan, using an interleaved protocol consisting of frames with alternating 2D and 3D acquisition. For each myocardial study, 13 volumes of interest were defined, representing 13 myocardial segments. First, the optimal scaling value for the scatter correction algorithm was determined using data from the phantom and four patient studies. This scaling value was then applied to all ten patients. 2D and 3D acquisitions were compared for both static (i.e. activity concentrations in the last 2D and 3D frames) and dynamic imaging (calculation of the metabolic rate of glucose).

Results

For both phantom and patient studies, suboptimal results were obtained when the default scaling value for the scatter correction algorithm was used. After adjusting the scaling value, for all ten myocardial FDG studies, a very good correlation (r ² = 0.99) was obtained between 2D and 3D data. With the present protocol no significant differences were observed in qualitative interpretation.

Conclusion

The 3D FDG acquisition mode is accurate and has clear advantages over the 2D mode for myocardial FDG studies. A prerequisite is, however, optimisation of the 3D scatter correction algorithm.

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Title: Accuracy of 3D acquisition mode for myocardial FDG PET studies using a BGO-based scanner
Authors: Arno P. van der Weerdt
Ronald Boellaard
Frans C. Visser
Adriaan A. Lammertsma
Publication date: 01-09-2007
Publisher: Springer-Verlag
Published in: European Journal of Nuclear Medicine and Molecular Imaging / Issue 9/2007
Print ISSN: 1619-7070
Electronic ISSN: 1619-7089
DOI: https://doi.org/10.1007/s00259-007-0367-8

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Accuracy of 3D acquisition mode for myocardial FDG PET studies using a BGO-based scanner

Abstract

Purpose

Methods

Results

Conclusion

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Abstract

Purpose

Methods

Results

Conclusion

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