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Published in: European Journal of Nuclear Medicine and Molecular Imaging 9/2007

01-09-2007 | Original article

Development of a cost-effective modular SPECT/CT scanner

Authors: Dale L. Bailey, Paul J. Roach, Elizabeth A. Bailey, James Hewlett, Ronnie Keijzers

Published in: European Journal of Nuclear Medicine and Molecular Imaging | Issue 9/2007

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Abstract

Purpose

To develop a combined SPECT/CT based on a conventional gamma camera with the following design goals: (i) the subject is scanned on the same bed without moving between SPECT and CT scans, (ii) maintenance of full diagnostic utility of both scanners, (iii) a minimal equipment footprint which is adaptable to different site configurations, (iv) a modular design so that either scanner can be upgraded without impacting the other scanner and (v) cost-effectiveness.

Methods

A Philips SKYLight gamma camera was combined with a single-slice helical CT. The CT bed has been modified by mounting on wheels and is attached to a track in the floor when required. The CT bed is used for both the CT and the SPECT scans. The CT bed is parked outside the SKYLight’s active area when not required. The CT data are used for anatomical localisation, attenuation correction and definition of anatomical boundaries (e.g. lobar boundaries in the lungs).

Results

The combined SPECT/CT system is installed in a 6.2 m×4.6 m room. The CT can scan up to 1.3 m of the subject, which is usually sufficient for registration with the SPECT scan. More than 200 subjects have had SPECT/CT scans in the first year of operation. Initially, the main outcome has been improved confidence of localisation of abnormalities. Attenuation correction for all relevant radionuclides has been implemented.

Conclusion

We have developed a combined SPECT/CT using a novel approach based on a low-cost CT scanner. The design is compact, is readily upgradeable and does not compromise either machine’s diagnostic or functional capabilities.
Literature
1.
go back to reference Kuhl DE, Hale J, Eaton WL. Transmission scanning: a useful adjunct to conventional emission scanning for accurately keying isotope deposition to radiographic anatomy. Radiology 1966;87:278.PubMed Kuhl DE, Hale J, Eaton WL. Transmission scanning: a useful adjunct to conventional emission scanning for accurately keying isotope deposition to radiographic anatomy. Radiology 1966;87:278.PubMed
2.
go back to reference Anger HO, McRae J. Transmission scintiphotography. J Nucl Med 1968;9(6):267–9.PubMed Anger HO, McRae J. Transmission scintiphotography. J Nucl Med 1968;9(6):267–9.PubMed
3.
go back to reference Sorenson JA, Briggs RC, Cameron JR. 99mTc point source for transmission scanning. J Nucl Med 1969;10(5):252–3.PubMed Sorenson JA, Briggs RC, Cameron JR. 99mTc point source for transmission scanning. J Nucl Med 1969;10(5):252–3.PubMed
4.
go back to reference Phelps ME, Hoffman EJ, Mullani NA, Ter-Pogossian MM. Application of annihilation coincidence detection to transaxial reconstruction tomography. J Nucl Med 1975;16(3):210–24.PubMed Phelps ME, Hoffman EJ, Mullani NA, Ter-Pogossian MM. Application of annihilation coincidence detection to transaxial reconstruction tomography. J Nucl Med 1975;16(3):210–24.PubMed
5.
go back to reference Morozumi T, Nakajima M, Ogawa K, Yuta S. Attenuation correction methods using the information of attenuation distribution for single photon emission CT. Med Imag Tech 1984;2:20–8. Morozumi T, Nakajima M, Ogawa K, Yuta S. Attenuation correction methods using the information of attenuation distribution for single photon emission CT. Med Imag Tech 1984;2:20–8.
6.
go back to reference Bailey DL, Hutton BF, Walker PJ. Improved SPECT using simultaneous emission and transmission tomography. J Nucl Med 1987;28(5):844–51.PubMed Bailey DL, Hutton BF, Walker PJ. Improved SPECT using simultaneous emission and transmission tomography. J Nucl Med 1987;28(5):844–51.PubMed
7.
go back to reference Butler SP, Bailey DL, McLaughlin AF, Khafagi FA, Stephens FO. SPECT evaluation of arterial perfusion in regional chemotherapy. J Nucl Med 1988;29(5):593–8.PubMed Butler SP, Bailey DL, McLaughlin AF, Khafagi FA, Stephens FO. SPECT evaluation of arterial perfusion in regional chemotherapy. J Nucl Med 1988;29(5):593–8.PubMed
8.
go back to reference Beyer T, Kinahan PE, Townsend DW, Sashin D. The use of X-ray CT for attenuation correction of PET data. In: Trendler RC (ed) IEEE Nuclear Science Symposium and Medical Imaging Conference; 1994; Norfolk, VA, USA: Inst of Electrical and Electronic Engineers; 1994. p. 1573–7. Beyer T, Kinahan PE, Townsend DW, Sashin D. The use of X-ray CT for attenuation correction of PET data. In: Trendler RC (ed) IEEE Nuclear Science Symposium and Medical Imaging Conference; 1994; Norfolk, VA, USA: Inst of Electrical and Electronic Engineers; 1994. p. 1573–7.
9.
go back to reference Beyer T, Townsend DW, Brun T, Kinahan PE, Charron M, Roddy R, et al. A combined PET/CT scanner for clinical oncology. J Nucl Med 2000;41(8):1369–79.PubMed Beyer T, Townsend DW, Brun T, Kinahan PE, Charron M, Roddy R, et al. A combined PET/CT scanner for clinical oncology. J Nucl Med 2000;41(8):1369–79.PubMed
10.
go back to reference Lang TF, Hasegawa BH, Liew SC, Brown JK, Blankespoor SC, Reilly SM, et al. Description of a prototype emission-transmission computed tomography imaging system. J Nucl Med 1992;33(10):1881–7.PubMed Lang TF, Hasegawa BH, Liew SC, Brown JK, Blankespoor SC, Reilly SM, et al. Description of a prototype emission-transmission computed tomography imaging system. J Nucl Med 1992;33(10):1881–7.PubMed
11.
go back to reference Bocher M, Balan A, Krausz Y, Shrem Y, Lonn A, Wilk M, et al. Gamma camera-mounted anatomical X-ray tomography: technology, system characteristics and first images. Eur J Nucl Med 2000;27(6):619–27.PubMedCrossRef Bocher M, Balan A, Krausz Y, Shrem Y, Lonn A, Wilk M, et al. Gamma camera-mounted anatomical X-ray tomography: technology, system characteristics and first images. Eur J Nucl Med 2000;27(6):619–27.PubMedCrossRef
12.
go back to reference Tan P, Bailey DL, Meikle SR, Eberl S, Fulton RR, Hutton BF. A scanning line source for simultaneous emission and transmission measurements in SPECT. J Nucl Med 1993;34(10):1752–60.PubMed Tan P, Bailey DL, Meikle SR, Eberl S, Fulton RR, Hutton BF. A scanning line source for simultaneous emission and transmission measurements in SPECT. J Nucl Med 1993;34(10):1752–60.PubMed
13.
go back to reference Hudson HM, Larkin RS. Accelerated image reconstruction using ordered subsets of projection data. IEEE Trans Med Imag 1994;MI-13(4):601–9.CrossRef Hudson HM, Larkin RS. Accelerated image reconstruction using ordered subsets of projection data. IEEE Trans Med Imag 1994;MI-13(4):601–9.CrossRef
14.
go back to reference Brown S, Bailey DL, Baldock CA. Relationship between CT Hounsfield units and linear attenuation coefficients for a number of single photon-emitting radionuclides [abstract]. J Nucl Med 2006;47(5 Suppl):381P. Brown S, Bailey DL, Baldock CA. Relationship between CT Hounsfield units and linear attenuation coefficients for a number of single photon-emitting radionuclides [abstract]. J Nucl Med 2006;47(5 Suppl):381P.
15.
go back to reference Philips. Installation and Siting Support - CT/PQ SERIES SYSTEM (400 VAC); 2000. Philips. Installation and Siting Support - CT/PQ SERIES SYSTEM (400 VAC); 2000.
16.
go back to reference Moss M, McLean D. Paediatric and adult computed tomography practice and patient dose in Australia. Australasian Radiol 2006;50:33–40.CrossRef Moss M, McLean D. Paediatric and adult computed tomography practice and patient dose in Australia. Australasian Radiol 2006;50:33–40.CrossRef
17.
go back to reference Kneifel S. Radiation dose and radiation protection. In: von Shultness GK (ed) Clinical molecular anatomic imaging. Philadelphia: Lippincott; 2003. p. 68–71. Kneifel S. Radiation dose and radiation protection. In: von Shultness GK (ed) Clinical molecular anatomic imaging. Philadelphia: Lippincott; 2003. p. 68–71.
18.
go back to reference ICRP. ICRP Publication 53: Radiation dose to patients from radiopharmaceuticals; 1988. ICRP. ICRP Publication 53: Radiation dose to patients from radiopharmaceuticals; 1988.
20.
go back to reference Towson JEC. Radiation dosimetry and protection in PET. In: Valk P, Bailey DL, Townsend DW, Maisey MN (eds) Positron emission tomography: basic science and clinical practice. London: Springer, 2003. Towson JEC. Radiation dosimetry and protection in PET. In: Valk P, Bailey DL, Townsend DW, Maisey MN (eds) Positron emission tomography: basic science and clinical practice. London: Springer, 2003.
21.
go back to reference Roach PJ, Schembri GP, Ho Shon IA, Bailey EA, Bailey DL. SPECT/CT imaging using a spiral CT scanner for anatomical localisation: impact on diagnostic accuracy and reporter confidence in clinical practice. Nucl Med Commun 2006;27:977–87.PubMedCrossRef Roach PJ, Schembri GP, Ho Shon IA, Bailey EA, Bailey DL. SPECT/CT imaging using a spiral CT scanner for anatomical localisation: impact on diagnostic accuracy and reporter confidence in clinical practice. Nucl Med Commun 2006;27:977–87.PubMedCrossRef
22.
go back to reference Delbeke D, Coleman RE, Guiberteau MJ, Brown ML, Royal HD, Siegel BA, et al. Procedure guideline for SPECT/CT imaging 1.0. J Nucl Med 2006;47(7):1227–34.PubMed Delbeke D, Coleman RE, Guiberteau MJ, Brown ML, Royal HD, Siegel BA, et al. Procedure guideline for SPECT/CT imaging 1.0. J Nucl Med 2006;47(7):1227–34.PubMed
23.
go back to reference Bailey DL. Is PET the future of nuclear medicine? (Invited Commentary). Eur J Nucl Med Mol Imag 2003;30(7):1045–6.CrossRef Bailey DL. Is PET the future of nuclear medicine? (Invited Commentary). Eur J Nucl Med Mol Imag 2003;30(7):1045–6.CrossRef
24.
go back to reference Kashiwagi T, Yutani K, Fukuchi M, Naruse H, Iwasaki T, Yokozuka K, et al. Correction of nonuniform attenuation and image fusion in SPECT imaging by means of separate X-ray CT. Ann Nucl Med 2002;16(4):255–61.PubMedCrossRef Kashiwagi T, Yutani K, Fukuchi M, Naruse H, Iwasaki T, Yokozuka K, et al. Correction of nonuniform attenuation and image fusion in SPECT imaging by means of separate X-ray CT. Ann Nucl Med 2002;16(4):255–61.PubMedCrossRef
25.
go back to reference Nehmeh SA, Erdi YE, Ling CC, Rosenzweig KE, Squire OD, Braban LE, et al. Effect of respiratory gating on reducing lung motion artifacts in PET imaging of lung cancer. Med Phys 2002;29(3):366–71.PubMedCrossRef Nehmeh SA, Erdi YE, Ling CC, Rosenzweig KE, Squire OD, Braban LE, et al. Effect of respiratory gating on reducing lung motion artifacts in PET imaging of lung cancer. Med Phys 2002;29(3):366–71.PubMedCrossRef
26.
go back to reference Lardinois D, Weder W, Hany TF, Kamel EM, Korom S, Seifert B, et al. Staging of non-small-cell lung cancer with integrated positron-emission tomography and computed tomography. N Engl J Med 2003;348:2500–7.PubMedCrossRef Lardinois D, Weder W, Hany TF, Kamel EM, Korom S, Seifert B, et al. Staging of non-small-cell lung cancer with integrated positron-emission tomography and computed tomography. N Engl J Med 2003;348:2500–7.PubMedCrossRef
27.
go back to reference Bar-Shalom R, Yefremov N, Guralnik L, Gaitini D, Frenkel A, Kuten A, et al. Clinical performance of PET/CT in evaluation of cancer: additional value for diagnostic imaging and patient management. J Nucl Med 2003;44(8):1200–9.PubMed Bar-Shalom R, Yefremov N, Guralnik L, Gaitini D, Frenkel A, Kuten A, et al. Clinical performance of PET/CT in evaluation of cancer: additional value for diagnostic imaging and patient management. J Nucl Med 2003;44(8):1200–9.PubMed
28.
go back to reference Coleman R, Delbeke D, Guiberteau M, Conti P, Royal H, Weinreb J, et al. Concurrent PET/CT with an integrated imaging system: intersociety dialogue from the Joint Working Group of the American College of Radiology, the Society of Nuclear Medicine, and the Society of Computed Body Tomography and Magnetic Resonance. J Nucl Med 2005;46:1225–39.PubMed Coleman R, Delbeke D, Guiberteau M, Conti P, Royal H, Weinreb J, et al. Concurrent PET/CT with an integrated imaging system: intersociety dialogue from the Joint Working Group of the American College of Radiology, the Society of Nuclear Medicine, and the Society of Computed Body Tomography and Magnetic Resonance. J Nucl Med 2005;46:1225–39.PubMed
29.
go back to reference Townsend DW, Cherry SR. Combining anatomy and function: the path to true image fusion. Eur Radiol 2001;11(10):1968–74.PubMedCrossRef Townsend DW, Cherry SR. Combining anatomy and function: the path to true image fusion. Eur Radiol 2001;11(10):1968–74.PubMedCrossRef
Metadata
Title
Development of a cost-effective modular SPECT/CT scanner
Authors
Dale L. Bailey
Paul J. Roach
Elizabeth A. Bailey
James Hewlett
Ronnie Keijzers
Publication date
01-09-2007
Publisher
Springer-Verlag
Published in
European Journal of Nuclear Medicine and Molecular Imaging / Issue 9/2007
Print ISSN: 1619-7070
Electronic ISSN: 1619-7089
DOI
https://doi.org/10.1007/s00259-006-0364-3

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