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European Journal of Nuclear Medicine and Molecular Imaging
Published in: European Journal of Nuclear Medicine and Molecular Imaging 2/2007

01-02-2007 | Original article

Resolution recovery in pinhole SPECT based on multi-ray projections: a phantom study

Authors: Christian Vanhove, Andriy Andreyev, Michel Defrise, Johan Nuyts, Axel Bossuyt

Published in: European Journal of Nuclear Medicine and Molecular Imaging | Issue 2/2007

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Abstract

Purpose

Low sensitivity can become a major problem when very small pinholes are used in SPECT imaging. Although a larger pinhole aperture will improve the sensitivity, this will be at the cost of the spatial resolution. With a view to improving the resolution–sensitivity trade-off, this paper explores an iterative reconstruction algorithm that models the pinhole aperture based on multi-ray projections.

Methods

This new implementation was validated using simulated data and phantom experiments. Two approaches were investigated. Firstly, the pinhole aperture was modelled in both the forward and the back projector. Secondly, the dual matrix implementation was investigated by modelling the pinhole aperture only in the forward projector. The systematic error, the full-width at half-maximum (FWHM) and the statistical error were quantified using the simulated data. Experimental phantom data were acquired for visual comparison with the reconstructions obtained from the simulated data.

Results

For a predefined number of iterations, the systematic error, the FWHM and the statistical error could be decreased when the pinhole aperture was modelled during iterative reconstruction. For a fixed, predefined statistical error of ±10%, smaller systematic errors and smaller FWHM were obtained when modelling the pinhole opening. When the dual matrix implementation was used, equivalent results could be obtained as when modelling the pinhole opening in both the forward and the back projector.

Conclusion

The multi-ray method to accomplish resolution recovery during the reconstruction of pinhole SPECT projection images offers a better trade-off between spatial resolution and noise compared with a reconstruction which does not model the pinhole aperture.
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Metadata
Title
Resolution recovery in pinhole SPECT based on multi-ray projections: a phantom study
Authors
Christian Vanhove
Andriy Andreyev
Michel Defrise
Johan Nuyts
Axel Bossuyt
Publication date
01-02-2007
Publisher
Springer-Verlag
Published in
European Journal of Nuclear Medicine and Molecular Imaging / Issue 2/2007
Print ISSN: 1619-7070
Electronic ISSN: 1619-7089
DOI
https://doi.org/10.1007/s00259-006-0225-0

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