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Published in: European Journal of Nuclear Medicine and Molecular Imaging 1/2005

01-01-2005 | Controversies-Against

Pulmonary embolism: is multislice CT the method of choice?

Author: Carl Schuemichen

Published in: European Journal of Nuclear Medicine and Molecular Imaging | Issue 1/2005

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Excerpt

Nobody is perfect—and this is also true of imaging techniques. In the case of ventilation/perfusion (V/Q) scintigraphy of the lung for diagnosis of acute pulmonary embolism (PE), this was clear from the beginning. Indirect visualisation of the embolus by functional imaging of the lung may cause false positive results and hence low specificity of the examination. It has also long been clear that V/Q scintigraphy should be replaced by a non-invasive procedure for direct visualisation of the embolus as soon as such a procedure is available. The introduction of multislice (multidetector row) technology has drastically reduced motion blurring in CT angiography and thus detection of small peripheral emboli seems to be possible. In some countries, multislice CT (MSCT) is already recommended as a first-line modality for the management of suspected acute pulmonary embolism (for example, the British Thoracic Society makes this recommendation). So which arguments besides the availability of MSCT still favour V/Q scintigraphy? …
Literature
1.
go back to reference Parker JA, Coleman RE, Siegel BA, Sostman HD, McKusick KA, Royal HD. Procedure guideline for lung scintigraphy: 1.0. Society of Nuclear Medicine. J Nucl Med 1996;37(11):1906–10.PubMed Parker JA, Coleman RE, Siegel BA, Sostman HD, McKusick KA, Royal HD. Procedure guideline for lung scintigraphy: 1.0. Society of Nuclear Medicine. J Nucl Med 1996;37(11):1906–10.PubMed
2.
go back to reference Reinartz P, Schirp U, Zimny M, Sabri O, Nowak B, Schäfer W, et al. Optimizing ventilation-perfusion lung scintigraphy: parting with planar imaging. Nuklearmedizin 2001;40(2):38–43.PubMed Reinartz P, Schirp U, Zimny M, Sabri O, Nowak B, Schäfer W, et al. Optimizing ventilation-perfusion lung scintigraphy: parting with planar imaging. Nuklearmedizin 2001;40(2):38–43.PubMed
3.
go back to reference Bajc M, Olsson CG, Olsson B, Palmer J, Jonson B. Diagnostic evaluation of planar and tomographic ventilation/perfusion lung images in patients with suspected pulmonary emboli. Clin Physiol Funct Imaging 2004;24:in press. Bajc M, Olsson CG, Olsson B, Palmer J, Jonson B. Diagnostic evaluation of planar and tomographic ventilation/perfusion lung images in patients with suspected pulmonary emboli. Clin Physiol Funct Imaging 2004;24:in press.
4.
go back to reference Bajc M, Bitzen U, Olsson B, Perez de Sa V, Palmer J, Jonson B. Lung ventilation/perfusion SPECT in the artificially embolized pig. J Nucl Med 2002;43:640–7.PubMed Bajc M, Bitzen U, Olsson B, Perez de Sa V, Palmer J, Jonson B. Lung ventilation/perfusion SPECT in the artificially embolized pig. J Nucl Med 2002;43:640–7.PubMed
5.
go back to reference Blachere H, Latrabe V, Montaudon M, Valli N, Couffinhal T, Raherisson C, et al. Pulmonary embolism revealed on helical CT angiography: comparison with ventilation-perfusion radionuclide lung scanning. Am J Roentgenol 2000;174(4):1041–7. Blachere H, Latrabe V, Montaudon M, Valli N, Couffinhal T, Raherisson C, et al. Pulmonary embolism revealed on helical CT angiography: comparison with ventilation-perfusion radionuclide lung scanning. Am J Roentgenol 2000;174(4):1041–7.
6.
go back to reference PIOPED Investigators. Value of the ventilation/perfusion scan in acute pulmonary embolism: results of the prospective investigation of pulmonary embolism diagnosis (PIOPED). JAMA 1990;263:2753–9. PIOPED Investigators. Value of the ventilation/perfusion scan in acute pulmonary embolism: results of the prospective investigation of pulmonary embolism diagnosis (PIOPED). JAMA 1990;263:2753–9.
7.
go back to reference Forbes KP, Reid JH, Murchison JT. Do preliminary chest X-ray findings define the optimum role of pulmonary scintigraphy in suspected pulmonary embolism? Clin Radiol 2001;56(5):397–400. Forbes KP, Reid JH, Murchison JT. Do preliminary chest X-ray findings define the optimum role of pulmonary scintigraphy in suspected pulmonary embolism? Clin Radiol 2001;56(5):397–400.
8.
go back to reference Gottschalk A. New criteria for ventilation-perfusion lung scan interpretation: a basis for optimal interaction with helical CT angiography. Radiographics 2000;20:1206–10.PubMed Gottschalk A. New criteria for ventilation-perfusion lung scan interpretation: a basis for optimal interaction with helical CT angiography. Radiographics 2000;20:1206–10.PubMed
9.
go back to reference Nilsson T, Mare K, Carlsson A. Value of structured clinical and scintigraphic protocols in acute pulmonary embolism. J Intern Med 2001;250(3):213–8.CrossRefPubMed Nilsson T, Mare K, Carlsson A. Value of structured clinical and scintigraphic protocols in acute pulmonary embolism. J Intern Med 2001;250(3):213–8.CrossRefPubMed
10.
go back to reference Baile EM, King GG, Muller NL, D’Yachkova Y, Coche EE, Pare PD, Mayo JR. Spiral computed tomography is comparable to angiography for the diagnosis of pulmonary embolism. Am J Respir Crit Care Med 2000;161:1010–5.PubMed Baile EM, King GG, Muller NL, D’Yachkova Y, Coche EE, Pare PD, Mayo JR. Spiral computed tomography is comparable to angiography for the diagnosis of pulmonary embolism. Am J Respir Crit Care Med 2000;161:1010–5.PubMed
11.
go back to reference Lorut C, Ghossains M, Horellou MH, Achkar A, Fretault J, Laaban JP. A noninvasive diagnostic strategy including spiral computed tomography in patients with suspected pulmonary embolism. Am J Respir Crit Care Med 2000;162(4):1413–8.PubMed Lorut C, Ghossains M, Horellou MH, Achkar A, Fretault J, Laaban JP. A noninvasive diagnostic strategy including spiral computed tomography in patients with suspected pulmonary embolism. Am J Respir Crit Care Med 2000;162(4):1413–8.PubMed
12.
go back to reference Perrier A, Howarth N, Didier D, Loubeyre P, Unger PF, de Moerloose P, et al. Performance of helical computed tomography in unselected outpatients with suspected pulmonary embolism. Ann Intern Med 2000;235(2):88–97. Perrier A, Howarth N, Didier D, Loubeyre P, Unger PF, de Moerloose P, et al. Performance of helical computed tomography in unselected outpatients with suspected pulmonary embolism. Ann Intern Med 2000;235(2):88–97.
13.
go back to reference van Rossum AB, Pattynama PM, Mallens WM, Hermans J, Heijerman HG. Can helical CT replace scintigraphy in the diagnostic process in suspected pulmonary embolism? A retrolective-prolective cohort study focusing on total diagnostic yield. Eur Radiol 1998;8(1):90–6.CrossRefPubMed van Rossum AB, Pattynama PM, Mallens WM, Hermans J, Heijerman HG. Can helical CT replace scintigraphy in the diagnostic process in suspected pulmonary embolism? A retrolective-prolective cohort study focusing on total diagnostic yield. Eur Radiol 1998;8(1):90–6.CrossRefPubMed
14.
go back to reference Schümichen C. V/Q-scanning/SPECT for the diagnosis of pulmonary embolism. Respiration 2003;70;329–42.CrossRefPubMed Schümichen C. V/Q-scanning/SPECT for the diagnosis of pulmonary embolism. Respiration 2003;70;329–42.CrossRefPubMed
15.
go back to reference Schoepf UJ, Costello P. CT angiography for diagnosis of pulmonary embolism: state of the art. Radiology 2004:230.(2):329–37PubMed Schoepf UJ, Costello P. CT angiography for diagnosis of pulmonary embolism: state of the art. Radiology 2004:230.(2):329–37PubMed
16.
go back to reference Mayo JR, Remy-Jardin M, Muller NL, Remy J, Worsley DF, Hossein-Foucher C, et al. Pulmonary embolism: prospective comparison of spiral CT with ventilations-perfusions scintigraphy. Radiology 1997;205(2):447–52.PubMed Mayo JR, Remy-Jardin M, Muller NL, Remy J, Worsley DF, Hossein-Foucher C, et al. Pulmonary embolism: prospective comparison of spiral CT with ventilations-perfusions scintigraphy. Radiology 1997;205(2):447–52.PubMed
17.
go back to reference van Erkel AR, van Rossum AB, Bloem JL, Kievit J, Pattynama PM. Spiral CT angiography for suspected pulmonary embolism: a cost-effectiveness analysis. Radiology 1996;201(1):29–36.PubMed van Erkel AR, van Rossum AB, Bloem JL, Kievit J, Pattynama PM. Spiral CT angiography for suspected pulmonary embolism: a cost-effectiveness analysis. Radiology 1996;201(1):29–36.PubMed
18.
go back to reference Otmani A, Tribouilloy C, Leborgne L, Vermes E, Trojette F, Beckers C, et al. Diagnostic value of echocardiography and thoracic spiral CT angiography in the diagnosis of acute pulmonary embolism. Ann Cardiol Angeiol 1998;47(10):707–15. Otmani A, Tribouilloy C, Leborgne L, Vermes E, Trojette F, Beckers C, et al. Diagnostic value of echocardiography and thoracic spiral CT angiography in the diagnosis of acute pulmonary embolism. Ann Cardiol Angeiol 1998;47(10):707–15.
19.
go back to reference Kettner BI, Einzweiler C, Sandrock D, Reisinger I, Munz DL. Electron beam computed tomography and ventilation perfusion scintigraphy in the diagnosis of pulmonary embolism. Eur J Nucl Med Mol Imaging 2002;29(5):585–90.CrossRefPubMed Kettner BI, Einzweiler C, Sandrock D, Reisinger I, Munz DL. Electron beam computed tomography and ventilation perfusion scintigraphy in the diagnosis of pulmonary embolism. Eur J Nucl Med Mol Imaging 2002;29(5):585–90.CrossRefPubMed
20.
go back to reference Reinarzt P, Wildberger JE, Schäfer W, Nowak B, Wieres FJ, Setani K, Büll U. Die SPECT-Technik in der Diagnostik pulmonaler Embolien: Vergleich zwischen V/Q-Lungenszintigraphie und Mehrschicht-Spiral-CT. Nuklearmedizin 2003;42(2):A70. Reinarzt P, Wildberger JE, Schäfer W, Nowak B, Wieres FJ, Setani K, Büll U. Die SPECT-Technik in der Diagnostik pulmonaler Embolien: Vergleich zwischen V/Q-Lungenszintigraphie und Mehrschicht-Spiral-CT. Nuklearmedizin 2003;42(2):A70.
21.
go back to reference Goodman LR, Lipchik RJ, Kuzo RS, Liu Y, McAuliffe TL, O’Brien DJ. Subsequent pulmonary embolism: risk after a negative helical CT pulmonary angiogram-prospective comparison with scintigraphy. Radiology 2000;215:535–42. Goodman LR, Lipchik RJ, Kuzo RS, Liu Y, McAuliffe TL, O’Brien DJ. Subsequent pulmonary embolism: risk after a negative helical CT pulmonary angiogram-prospective comparison with scintigraphy. Radiology 2000;215:535–42.
22.
go back to reference Tillie-Leblond I, Mastora I, Radenne F, Paillard S, Tonnel AB, Remy J, Remy-Jardin M. Risk of pulmonary embolism after a negative spiral CT angiogram in patients with pulmonary disease: 1-year clinical follow-up study. Radiology 2002;223(2):461–7.PubMed Tillie-Leblond I, Mastora I, Radenne F, Paillard S, Tonnel AB, Remy J, Remy-Jardin M. Risk of pulmonary embolism after a negative spiral CT angiogram in patients with pulmonary disease: 1-year clinical follow-up study. Radiology 2002;223(2):461–7.PubMed
23.
go back to reference Swensen SJ, Sheedy PF II, Ryu JH, Pickett DD, Schleck CD, Ilstrup DM, Heit JA. Outcomes after withholding anticoagulation from patients with suspected acute pulmonary embolism and negative computed tomographic findings: a cohort study. Mayo Clin Proc 2002;77(2):130–138.PubMed Swensen SJ, Sheedy PF II, Ryu JH, Pickett DD, Schleck CD, Ilstrup DM, Heit JA. Outcomes after withholding anticoagulation from patients with suspected acute pulmonary embolism and negative computed tomographic findings: a cohort study. Mayo Clin Proc 2002;77(2):130–138.PubMed
24.
go back to reference Henry JW, Relyea B, Stein PD. Continuing risk of thromboemboli among patients with normal pulmonary angiograms. Chest 1995;107(5):1375–8.PubMed Henry JW, Relyea B, Stein PD. Continuing risk of thromboemboli among patients with normal pulmonary angiograms. Chest 1995;107(5):1375–8.PubMed
25.
go back to reference Schümichen C. Leitlinien für die Lungenszintigraphie. Nuklearmedizin 1999;38(6a):233–6.PubMed Schümichen C. Leitlinien für die Lungenszintigraphie. Nuklearmedizin 1999;38(6a):233–6.PubMed
26.
go back to reference Nishizawa K, Matsumoto M, Iwai K, Tonari A, Yoshida T, Takayama M. Dose evaluation and effective dose estimation from multi detector CT. Igaku Butsuri 2002;22(3):152–8.PubMed Nishizawa K, Matsumoto M, Iwai K, Tonari A, Yoshida T, Takayama M. Dose evaluation and effective dose estimation from multi detector CT. Igaku Butsuri 2002;22(3):152–8.PubMed
27.
go back to reference Mahesh M, Scatariger JC, Cooper J, Fishmann EK. Dose and pitch relationship for a particular multislice CT scanner. Am J Roentgenol 2001;177(6):11273–5. Mahesh M, Scatariger JC, Cooper J, Fishmann EK. Dose and pitch relationship for a particular multislice CT scanner. Am J Roentgenol 2001;177(6):11273–5.
28.
go back to reference Land CE, Tokunaga M, Tokuoka S, Nakamura N. Early-onset breast cancer in A-bomb survivors. Lancet 1993;342(8865):237.CrossRef Land CE, Tokunaga M, Tokuoka S, Nakamura N. Early-onset breast cancer in A-bomb survivors. Lancet 1993;342(8865):237.CrossRef
29.
go back to reference Hopper KD, King SH, Lobell ME, TenHave TR, Weaver JS. The breast: in plane X-ray protection during diagnostic thoracic CT-shielding with bismuth radioprotective garments. Radiology 1997;205:853–8.PubMed Hopper KD, King SH, Lobell ME, TenHave TR, Weaver JS. The breast: in plane X-ray protection during diagnostic thoracic CT-shielding with bismuth radioprotective garments. Radiology 1997;205:853–8.PubMed
30.
go back to reference Valentin J. Radiation dose to patients from radiopharmaceuticals. Addendum 2 to ICRP Publication 53. ICRP Publication 80. Ann ICRP 1998;28(3):1.CrossRef Valentin J. Radiation dose to patients from radiopharmaceuticals. Addendum 2 to ICRP Publication 53. ICRP Publication 80. Ann ICRP 1998;28(3):1.CrossRef
31.
go back to reference Greess H, Lutz J, Nomayr A, Wolf H, Hothorn T, Kalender WA, Bautz W. Dose reduction in subsecond multislice spiral CT examination of children by online tube current modulation. Eur Radiol 2004;14(6):995–9. Greess H, Lutz J, Nomayr A, Wolf H, Hothorn T, Kalender WA, Bautz W. Dose reduction in subsecond multislice spiral CT examination of children by online tube current modulation. Eur Radiol 2004;14(6):995–9.
32.
go back to reference Greess H, Wolf H, Suess C, Kalender WA, Bautz W, Baum U. Automatic exposure control to reduce the dose in subsecond multislice spiral CT: phantom measurements and clinical results. Röfo 2004;176(6):862–9. Greess H, Wolf H, Suess C, Kalender WA, Bautz W, Baum U. Automatic exposure control to reduce the dose in subsecond multislice spiral CT: phantom measurements and clinical results. Röfo 2004;176(6):862–9.
33.
go back to reference Mastora I, Remy-Jardin M, Delannoy V, Duhamel A, Scherf C, Suess C, Remy J. Multi-detector row spiral CT angiography of the thoracic outlet: dose reduction with anatomically adapted online tube current modulation and preset dose savings. Radiology 2004;230(1):116–24.PubMed Mastora I, Remy-Jardin M, Delannoy V, Duhamel A, Scherf C, Suess C, Remy J. Multi-detector row spiral CT angiography of the thoracic outlet: dose reduction with anatomically adapted online tube current modulation and preset dose savings. Radiology 2004;230(1):116–24.PubMed
34.
go back to reference Thomsen HS, Morcos SK. Management of acute adverse reactions to contrast media. Eur Radiol 2004;14:476–81.CrossRefPubMed Thomsen HS, Morcos SK. Management of acute adverse reactions to contrast media. Eur Radiol 2004;14:476–81.CrossRefPubMed
Metadata
Title
Pulmonary embolism: is multislice CT the method of choice?
Author
Carl Schuemichen
Publication date
01-01-2005
Publisher
Springer-Verlag
Published in
European Journal of Nuclear Medicine and Molecular Imaging / Issue 1/2005
Print ISSN: 1619-7070
Electronic ISSN: 1619-7089
DOI
https://doi.org/10.1007/s00259-004-1679-6

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