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Published in: Skeletal Radiology 4/2022

01-04-2022 | Ultrasound | Review Article

Ultrasound of myxofibrosarcoma

Authors: Yoav Morag, David R. Lucas

Published in: Skeletal Radiology | Issue 4/2022

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Abstract

The ultrasound appearance of myxofibrosarcoma is highly variable corresponding to its variable and at times heterogeneous histopathologic appearance. Myxofibrosarcomas may mimic a benign process and the infiltrative tumor margins may be difficult to precisely delineate on ultrasound imaging. These tumor characteristics pose a diagnostic challenge on ultrasound evaluation. The radiologist should be aware of the variable morphologic presentation and infiltrative nature of myxofibrosarcoma and the limitations of ultrasound in the initial diagnosis, biopsy guidance, and post-surgical follow-up of this tumor.
Literature
1.
go back to reference Waters B, Panicek DM, Lefkowitz RA, Antonescu CR, Healey JH, Athanasian EA, et al. Low-grade myxofibrosarcoma: CT and MRI patterns in recurrent disease. AJR Am J Roentgenol. 2007;188(2):W193–8.CrossRef Waters B, Panicek DM, Lefkowitz RA, Antonescu CR, Healey JH, Athanasian EA, et al. Low-grade myxofibrosarcoma: CT and MRI patterns in recurrent disease. AJR Am J Roentgenol. 2007;188(2):W193–8.CrossRef
2.
go back to reference Petscavage-Thomas JM, Walker EA, Logie CI, Clarke LE, Duryea DM, Murphey MD. Soft-tissue myxomatous lesions: review of salient imaging features with pathologic comparison. Radiographics. 2014;34(4):964–80.CrossRef Petscavage-Thomas JM, Walker EA, Logie CI, Clarke LE, Duryea DM, Murphey MD. Soft-tissue myxomatous lesions: review of salient imaging features with pathologic comparison. Radiographics. 2014;34(4):964–80.CrossRef
3.
go back to reference Roland CL, Wang WL, Lazar AJ, Torres KE. Myxofibrosarcoma. Surg Oncol Clin N Am. 2016;25(4):775–88.CrossRef Roland CL, Wang WL, Lazar AJ, Torres KE. Myxofibrosarcoma. Surg Oncol Clin N Am. 2016;25(4):775–88.CrossRef
4.
go back to reference Hornick JL. Subclassification of pleomorphic sarcomas: how and why should we care? Ann Diagn Pathol. 2018;37:118–24.CrossRef Hornick JL. Subclassification of pleomorphic sarcomas: how and why should we care? Ann Diagn Pathol. 2018;37:118–24.CrossRef
5.
go back to reference Mentzel T, Calonje E, Wadden C, Camplejohn RS, Beham A, Smith MA, et al. Myxofibrosarcoma. Clinicopathologic analysis of 75 cases with emphasis on the low-grade variant. Am J Surg Pathol. 1996;20(4):391–405. Mentzel T, Calonje E, Wadden C, Camplejohn RS, Beham A, Smith MA, et al. Myxofibrosarcoma. Clinicopathologic analysis of 75 cases with emphasis on the low-grade variant. Am J Surg Pathol. 1996;20(4):391–405.
6.
go back to reference Charnock M. Soft-tissue sarcoma masquerading as a haematoma. J Med Ultrasound. 2019;27(1):50–3.CrossRef Charnock M. Soft-tissue sarcoma masquerading as a haematoma. J Med Ultrasound. 2019;27(1):50–3.CrossRef
7.
go back to reference Wada T, Hasegawa T, Nagoya S, Kawaguchi S, Kaya M, Ishii S. Myxofibrosarcoma with an infiltrative growth pattern: a case report. Jpn J Clin Oncol. 2000;30(10):458–62.CrossRef Wada T, Hasegawa T, Nagoya S, Kawaguchi S, Kaya M, Ishii S. Myxofibrosarcoma with an infiltrative growth pattern: a case report. Jpn J Clin Oncol. 2000;30(10):458–62.CrossRef
8.
go back to reference Yoo HJ, Hong SH, Kang Y, Choi JY, Moon KC, Kim HS, et al. MR imaging of myxofibrosarcoma and undifferentiated sarcoma with emphasis on tail sign; diagnostic and prognostic value. Eur Radiol. 2014;24(8):1749–57.CrossRef Yoo HJ, Hong SH, Kang Y, Choi JY, Moon KC, Kim HS, et al. MR imaging of myxofibrosarcoma and undifferentiated sarcoma with emphasis on tail sign; diagnostic and prognostic value. Eur Radiol. 2014;24(8):1749–57.CrossRef
9.
go back to reference Huang HY, Lal P, Qin J, Brennan MF, Antonescu CR. Low-grade myxofibrosarcoma: a clinicopathologic analysis of 49 cases treated at a single institution with simultaneous assessment of the efficacy of 3-tier and 4-tier grading systems. Hum Pathol. 2004;35(5):612–21.CrossRef Huang HY, Lal P, Qin J, Brennan MF, Antonescu CR. Low-grade myxofibrosarcoma: a clinicopathologic analysis of 49 cases treated at a single institution with simultaneous assessment of the efficacy of 3-tier and 4-tier grading systems. Hum Pathol. 2004;35(5):612–21.CrossRef
10.
go back to reference Kikuta K, Kubota D, Yoshida A, Morioka H, Toyama Y, Chuuman H, et al. An analysis of factors related to the tail-like pattern of myxofibrosarcoma seen on MRI. Skeletal Radiol. 2015;44(1):55–62.CrossRef Kikuta K, Kubota D, Yoshida A, Morioka H, Toyama Y, Chuuman H, et al. An analysis of factors related to the tail-like pattern of myxofibrosarcoma seen on MRI. Skeletal Radiol. 2015;44(1):55–62.CrossRef
11.
go back to reference Kaya M, Wada T, Nagoya S, Sasaki M, Matsumura T, Yamaguchi T, et al. MRI and histological evaluation of the infiltrative growth pattern of myxofibrosarcoma. Skeletal Radiol. 2008;37(12):1085–90.CrossRef Kaya M, Wada T, Nagoya S, Sasaki M, Matsumura T, Yamaguchi T, et al. MRI and histological evaluation of the infiltrative growth pattern of myxofibrosarcoma. Skeletal Radiol. 2008;37(12):1085–90.CrossRef
12.
go back to reference Scoccianti G, Ranucci V, Frenos F, Greto D, Beltrami G, Capanna R, et al. Soft tissue myxofibrosarcoma: a clinico-pathological analysis of a series of 75 patients with emphasis on the epithelioid variant. J Surg Oncol. 2016;114(1):50–5.CrossRef Scoccianti G, Ranucci V, Frenos F, Greto D, Beltrami G, Capanna R, et al. Soft tissue myxofibrosarcoma: a clinico-pathological analysis of a series of 75 patients with emphasis on the epithelioid variant. J Surg Oncol. 2016;114(1):50–5.CrossRef
13.
go back to reference Ghazala CG, Agni NR, Ragbir M, Dildey P, Lee D, Rankin KS, et al. Myxofibrosarcoma of the extremity and trunk: a multidisciplinary approach leads to good local rates of LOCAL control. Bone Joint J. 2016;98-B(12):1682–8. Ghazala CG, Agni NR, Ragbir M, Dildey P, Lee D, Rankin KS, et al. Myxofibrosarcoma of the extremity and trunk: a multidisciplinary approach leads to good local rates of LOCAL control. Bone Joint J. 2016;98-B(12):1682–8.
15.
go back to reference Catalano O, Varelli C, Sbordone C, Corvino A, De Rosa D, Vallone G, et al. A bump: what to do next? Ultrasound imaging of superficial soft-tissue palpable lesions. J Ultrasound. 2020;23(3):287–300.CrossRef Catalano O, Varelli C, Sbordone C, Corvino A, De Rosa D, Vallone G, et al. A bump: what to do next? Ultrasound imaging of superficial soft-tissue palpable lesions. J Ultrasound. 2020;23(3):287–300.CrossRef
16.
go back to reference Murphey MD, Ruble CM, Tyszko SM, Zbojniewicz AM, Potter BK, Miettinen M. From the archives of the AFIP: musculoskeletal fibromatoses: radiologic-pathologic correlation. Radiographics. 2009;29(7):2143–73.CrossRef Murphey MD, Ruble CM, Tyszko SM, Zbojniewicz AM, Potter BK, Miettinen M. From the archives of the AFIP: musculoskeletal fibromatoses: radiologic-pathologic correlation. Radiographics. 2009;29(7):2143–73.CrossRef
17.
go back to reference Spinnato P, Clinca R. MRI tail sign in soft-tissue sarcoma. Radiology. 2021;299(2):276.CrossRef Spinnato P, Clinca R. MRI tail sign in soft-tissue sarcoma. Radiology. 2021;299(2):276.CrossRef
18.
go back to reference Mutter RW, Singer S, Zhang Z, Brennan MF, Alektiar KM. The enigma of myxofibrosarcoma of the extremity. Cancer. 2012;118(2):518–27.CrossRef Mutter RW, Singer S, Zhang Z, Brennan MF, Alektiar KM. The enigma of myxofibrosarcoma of the extremity. Cancer. 2012;118(2):518–27.CrossRef
19.
go back to reference Wagner JM, Rebik K, Spicer PJ. Ultrasound of soft tissue masses and fluid collections. Radiol Clin North Am. 2019;57(3):657–69.CrossRef Wagner JM, Rebik K, Spicer PJ. Ultrasound of soft tissue masses and fluid collections. Radiol Clin North Am. 2019;57(3):657–69.CrossRef
20.
go back to reference Hung EH, Griffith JF, Ng AW, Lee RK, Lau DT, Leung JC. Ultrasound of musculoskeletal soft-tissue tumors superficial to the investing fascia. AJR Am J Roentgenol. 2014;202(6):W532–40.CrossRef Hung EH, Griffith JF, Ng AW, Lee RK, Lau DT, Leung JC. Ultrasound of musculoskeletal soft-tissue tumors superficial to the investing fascia. AJR Am J Roentgenol. 2014;202(6):W532–40.CrossRef
21.
go back to reference Rowbotham E, Bhuva S, Gupta H, Robinson P. Assessment of referrals into the soft tissue sarcoma service: evaluation of imaging early in the pathway process. Sarcoma. 2012;2012:781723. Rowbotham E, Bhuva S, Gupta H, Robinson P. Assessment of referrals into the soft tissue sarcoma service: evaluation of imaging early in the pathway process. Sarcoma. 2012;2012:781723.
22.
go back to reference Lakkaraju A, Sinha R, Garikipati R, Edward S, Robinson P. Ultrasound for initial evaluation and triage of clinically suspicious soft-tissue masses. Clin Radiol. 2009;64(6):615–21.CrossRef Lakkaraju A, Sinha R, Garikipati R, Edward S, Robinson P. Ultrasound for initial evaluation and triage of clinically suspicious soft-tissue masses. Clin Radiol. 2009;64(6):615–21.CrossRef
23.
go back to reference Schulte M, von Baer A, Schultheiss M, Scheil-Bertram S. Classification of solid soft tissue tumours by ultrasonography. Ultraschall Med. 2010;31(2):182–90.CrossRef Schulte M, von Baer A, Schultheiss M, Scheil-Bertram S. Classification of solid soft tissue tumours by ultrasonography. Ultraschall Med. 2010;31(2):182–90.CrossRef
24.
go back to reference Gruber L, Loizides A, Luger AK, Glodny B, Moser P, Henninger B, et al. Soft-tissue tumor contrast enhancement patterns: diagnostic value and comparison between ultrasound and MRI. AJR Am J Roentgenol. 2017;208(2):393–401.CrossRef Gruber L, Loizides A, Luger AK, Glodny B, Moser P, Henninger B, et al. Soft-tissue tumor contrast enhancement patterns: diagnostic value and comparison between ultrasound and MRI. AJR Am J Roentgenol. 2017;208(2):393–401.CrossRef
25.
go back to reference Rohela H, Lee C, Yoo HJ, Kim HS, Kim Y, Cho HS, et al. Comparison of the diagnostic performances of core needle biopsy in myxoid versus non-myxoid tumors. Eur J Surg Oncol. 2019;45(7):1293–8.CrossRef Rohela H, Lee C, Yoo HJ, Kim HS, Kim Y, Cho HS, et al. Comparison of the diagnostic performances of core needle biopsy in myxoid versus non-myxoid tumors. Eur J Surg Oncol. 2019;45(7):1293–8.CrossRef
26.
go back to reference Riouallon G, Larousserie F, Pluot E, Anract P. Superficial myxofibrosarcoma: assessment of recurrence risk according to the surgical margin following resection. A series of 21 patients. Orthop Traumatol Surg Res. 2013;99(4):473–7. Riouallon G, Larousserie F, Pluot E, Anract P. Superficial myxofibrosarcoma: assessment of recurrence risk according to the surgical margin following resection. A series of 21 patients. Orthop Traumatol Surg Res. 2013;99(4):473–7.
28.
go back to reference Peer S, Freuis T, Loizides A, Gruber H. Ultrasound guided core needle biopsy of soft tissue tumors; a fool proof technique? Med Ultrason. 2011;13(3):187–94.PubMed Peer S, Freuis T, Loizides A, Gruber H. Ultrasound guided core needle biopsy of soft tissue tumors; a fool proof technique? Med Ultrason. 2011;13(3):187–94.PubMed
29.
go back to reference Yoshimoto M, Yamada Y, Ishihara S, Kohashi K, Toda Y, Ito Y, et al. Comparative study of myxofibrosarcoma with undifferentiated pleomorphic sarcoma: histopathologic and clinicopathologic review. Am J Surg Pathol. 2020;44(1):87–97.CrossRef Yoshimoto M, Yamada Y, Ishihara S, Kohashi K, Toda Y, Ito Y, et al. Comparative study of myxofibrosarcoma with undifferentiated pleomorphic sarcoma: histopathologic and clinicopathologic review. Am J Surg Pathol. 2020;44(1):87–97.CrossRef
30.
go back to reference Kilpatrick SE, Ward WG. Myxofibrosarcoma of soft tissues: cytomorphologic analysis of a series. Diagn Cytopathol. 1999;20(1):6–9.CrossRef Kilpatrick SE, Ward WG. Myxofibrosarcoma of soft tissues: cytomorphologic analysis of a series. Diagn Cytopathol. 1999;20(1):6–9.CrossRef
31.
go back to reference Meek RD, Mills MK, Hanrahan CJ, Beckett BR, Leake RL, Allen H, et al. Pearls and pitfalls for soft-tissue and bone biopsies: a cross-institutional review. Radiographics. 2020;40(1):266–90.CrossRef Meek RD, Mills MK, Hanrahan CJ, Beckett BR, Leake RL, Allen H, et al. Pearls and pitfalls for soft-tissue and bone biopsies: a cross-institutional review. Radiographics. 2020;40(1):266–90.CrossRef
Metadata
Title
Ultrasound of myxofibrosarcoma
Authors
Yoav Morag
David R. Lucas
Publication date
01-04-2022
Publisher
Springer Berlin Heidelberg
Published in
Skeletal Radiology / Issue 4/2022
Print ISSN: 0364-2348
Electronic ISSN: 1432-2161
DOI
https://doi.org/10.1007/s00256-021-03869-7

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