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Skeletal Radiology
Published in: Skeletal Radiology 4/2019

01-04-2019 | Scientific Article

Magnetic resonance imaging of the craniovertebral junction in early rheumatoid arthritis

Authors: Marina Carotti, Fausto Salaffi, Marco Di Carlo, Francesco Sessa, Andrea Giovagnoni

Published in: Skeletal Radiology | Issue 4/2019

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Abstract

Objective

To assess the involvement of the atlantoaxial joint in patients with early rheumatoid arthritis (ERA) and to elucidate the risk profile for the individual patient.

Materials and methods

Consecutive ERA patients (disease duration < 12 months) were included in our study. A cervical spine magnetic resonance imaging (MRI) and X-rays (cervical spine, hands, wrists, and feet) were performed in all patients. The MRI features were correlated with clinical, radiological, and biochemical variables.

Results

Fifty patients (13 men and 37 women) with a mean age of 58.2 years (range, 36–79 years) were included in the study. In 12 (24%) patients were detectable MRI findings suggestive of the craniovertebral junction involvement. Compared with patients without cervical involvement, the patients with atlantoaxial synovitis showed a significantly higher anti-citrullinated protein antibodies (ACPA) titer [mean 200.25 UI (SD 262.44) vs. mean 22.05 (SD 40.21) (p < 0.001)]; a worse Disease Activity Score 44 joints (DAS44) [mean 5.72 (SD 0.44) vs. mean 4.52 (SD 0.53) (p < 0.001)]; a worse Health Assessment Questionnaire Disability Index (HAQ-DI) [mean 1.55 (SD 0.37) vs. mean 1.09 (SD 0.33) (p < 0.001)], and a higher Simple Erosion Narrowing Score (SENS) [mean 15.83 (SD 4.52) vs. mean 7.71 (SD 3.43) (p < 0.001)]. The multivariate analysis revealed a meaningful relationship between atlantoaxial synovitis and ACPA, DAS44, and the presence of an erosive disease.

Conclusions

The craniovertebral junction is frequently involved in ERA patients. ACPA, high disease activity, and erosive disease at baseline are predictors of atlantoaxial involvement.
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Metadata
Title
Magnetic resonance imaging of the craniovertebral junction in early rheumatoid arthritis
Authors
Marina Carotti
Fausto Salaffi
Marco Di Carlo
Francesco Sessa
Andrea Giovagnoni
Publication date
01-04-2019
Publisher
Springer Berlin Heidelberg
Published in
Skeletal Radiology / Issue 4/2019
Print ISSN: 0364-2348
Electronic ISSN: 1432-2161
DOI
https://doi.org/10.1007/s00256-018-3055-9

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