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Published in: Skeletal Radiology 12/2018

01-12-2018 | Technical Report

T2-mapping of the sacroiliac joints at 1.5 Tesla: a feasibility and reproducibility study

Authors: Domenico Albano, Vito Chianca, Renato Cuocolo, Rodolfo Bignone, Francesco Ciccia, Luca Maria Sconfienza, Massimo Midiri, Arturo Brunetti, Roberto Lagalla, Massimo Galia

Published in: Skeletal Radiology | Issue 12/2018

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Abstract

Objective

To evaluate the reproducibility of T2 relaxation time measurements of the sacroiliac joints at 1.5 T.

Materials and methods

Healthy volunteers underwent an oblique axial multislice multiecho spin-echo sequence of the sacroiliac joints at 1.5 T. Regions of interest were manually drawn using a dedicated software by two musculoskeletal radiologists to include the cartilaginous part of the sacroiliac joints. A senior radiologist performed the measurement twice, while a resident measured once. Intra- and inter-observer reproducibility was tested using the Bland-Altman method. Association between sex and T2 relaxation times was tested using the Mann-Whitney U test. Correlation between T2 relaxation times and body mass index (BMI) was tested using the Spearman’s rho.

Results

Eighty sacroiliac joints of 40 subjects (mean age: 28 ± 4.8 years, range: 20–43; mean BMI: 23.3 ± 3.1, range: 18.9–30) were imaged. The mean T2 values obtained by the senior radiologist in the first series of measurements were 42 ± 4.4 ms, whereas in the second series were 40.7 ± 4.5 ms. The mean T2 values obtained by the radiology resident were 41.1 ± 4.2 ms. Intra-observer reproducibility was 88% (coefficient of repeatability = 3.8; bias = 1.28; p < .001), while inter-observer reproducibility was 86% (4.7; −.88; p < .001). There was significant association between sex and T2 relaxation times (p = .024) and significant inverse correlation between T2 relaxation times and BMI (r = −.340, p = .002).

Conclusion

The assessment of T2 relaxation time measurements of sacroiliac joints seems to be highly reproducible at 1.5 T. Further studies could investigate the potential clinical application of this tool in the sacroiliac joints.
Literature
1.
go back to reference Hafezi-Nejad N, Zikria B, Eng J, Carrino JA, Demehri S. Predictive value of semi-quantitative MRI-based scoring systems for future knee replacement: data from the osteoarthritis initiative. Skelet Radiol. 2015;44:1655–62.CrossRef Hafezi-Nejad N, Zikria B, Eng J, Carrino JA, Demehri S. Predictive value of semi-quantitative MRI-based scoring systems for future knee replacement: data from the osteoarthritis initiative. Skelet Radiol. 2015;44:1655–62.CrossRef
2.
go back to reference Albano D, Martinelli N, Bianchi A, Messina C, Malerba F, Sconfienza LM. Clinical and imaging outcome of osteochondral lesions of the talus treated using autologous matrix induced chondrogenesis technique with a biomimetic scaffold. BMC Musculoskelet Disord. 2017;18:306.CrossRef Albano D, Martinelli N, Bianchi A, Messina C, Malerba F, Sconfienza LM. Clinical and imaging outcome of osteochondral lesions of the talus treated using autologous matrix induced chondrogenesis technique with a biomimetic scaffold. BMC Musculoskelet Disord. 2017;18:306.CrossRef
3.
go back to reference Quirbach S, Trattnig S, Marlovits S, et al. Initial results of in vivo high-resolution morphological and biochemical cartilage imaging of patients after matrix-associated autologous chondrocyte transplantation (MACT) of the ankle. Skelet Radiol. 2009;38:751–60.CrossRef Quirbach S, Trattnig S, Marlovits S, et al. Initial results of in vivo high-resolution morphological and biochemical cartilage imaging of patients after matrix-associated autologous chondrocyte transplantation (MACT) of the ankle. Skelet Radiol. 2009;38:751–60.CrossRef
4.
go back to reference Albano D, Martinelli N, Bianchi A, Giacalone A, Sconfienza LM. Evaluation of reproducibility of the MOCART score in patients with osteochondral lesions of the talus repaired using the autologous matrix-induced chondrogenesis technique. Radiol Med. 2017;122:909–17.CrossRef Albano D, Martinelli N, Bianchi A, Giacalone A, Sconfienza LM. Evaluation of reproducibility of the MOCART score in patients with osteochondral lesions of the talus repaired using the autologous matrix-induced chondrogenesis technique. Radiol Med. 2017;122:909–17.CrossRef
5.
go back to reference Apprich S, Welsch GH, Mamisch TC, et al. Detection of degenerative cartilage disease: comparison of high-resolution morphological MR and quantitative T2 mapping at 3.0 Tesla. Osteoarthr Cartil. 2010;18:1211–7.CrossRef Apprich S, Welsch GH, Mamisch TC, et al. Detection of degenerative cartilage disease: comparison of high-resolution morphological MR and quantitative T2 mapping at 3.0 Tesla. Osteoarthr Cartil. 2010;18:1211–7.CrossRef
6.
go back to reference Kim T, Min BH, Yoon SH, Kim H, Park S, Lee HY, et al. An in vitro comparative study of T2 and T2* mappings of human articular cartilage at 3-Tesla MRI using histology as the standard of reference. Skelet Radiol. 2014;43:947–54.CrossRef Kim T, Min BH, Yoon SH, Kim H, Park S, Lee HY, et al. An in vitro comparative study of T2 and T2* mappings of human articular cartilage at 3-Tesla MRI using histology as the standard of reference. Skelet Radiol. 2014;43:947–54.CrossRef
7.
go back to reference David-Vaudey E, Ghosh S, Ries M, et al. T2 relaxation time measurements in osteoarthritis. Magn Reson Imaging. 2004;22:673–82.CrossRef David-Vaudey E, Ghosh S, Ries M, et al. T2 relaxation time measurements in osteoarthritis. Magn Reson Imaging. 2004;22:673–82.CrossRef
8.
go back to reference Dunn TC, Lu Y, Jin H, Ries MD, Majumdar S. T2 relaxation time of cartilage at MR imaging: comparison with severity of knee osteoarthritis. Radiology. 2004;232:592–8.CrossRef Dunn TC, Lu Y, Jin H, Ries MD, Majumdar S. T2 relaxation time of cartilage at MR imaging: comparison with severity of knee osteoarthritis. Radiology. 2004;232:592–8.CrossRef
9.
go back to reference Lee S, Yoon YC, Kim JH. T2 mapping of the articular cartilage in the ankle: correlation to the status of anterior talofibular ligament. Clin Radiol. 2013;68:e355–61.CrossRef Lee S, Yoon YC, Kim JH. T2 mapping of the articular cartilage in the ankle: correlation to the status of anterior talofibular ligament. Clin Radiol. 2013;68:e355–61.CrossRef
10.
go back to reference Watanabe A, Boesch C, Siebenrock K, Obata T, Anderson SE. T2 mapping of hip articular cartilage in healthy volunteers at 3T: a study of topographic variation. J Magn Reson Imaging. 2007;26:165–71.CrossRef Watanabe A, Boesch C, Siebenrock K, Obata T, Anderson SE. T2 mapping of hip articular cartilage in healthy volunteers at 3T: a study of topographic variation. J Magn Reson Imaging. 2007;26:165–71.CrossRef
11.
go back to reference Maizlin ZV, Clement JJ, Patola WB, et al. T2 mapping of articular cartilage of glenohumeral joint with routine MRI correlation: initial experience. HSS J. 2009;5:61–6.CrossRef Maizlin ZV, Clement JJ, Patola WB, et al. T2 mapping of articular cartilage of glenohumeral joint with routine MRI correlation: initial experience. HSS J. 2009;5:61–6.CrossRef
12.
go back to reference Marzo-Ortega H, McGonagle D, Bennett AN. Magnetic resonance imaging in spondyloarthritis. Curr Opin Rheumatol. 2010;22:381–7.CrossRef Marzo-Ortega H, McGonagle D, Bennett AN. Magnetic resonance imaging in spondyloarthritis. Curr Opin Rheumatol. 2010;22:381–7.CrossRef
13.
go back to reference Lefebvre G, Bergère A, El Rafei M, Duhamel A, Teixeira P, Cotten A. T2 mapping of the sacroiliac joints with 3-T MRI: a preliminary study. AJR Am J Roentgenol. 2017;209:389–94.CrossRef Lefebvre G, Bergère A, El Rafei M, Duhamel A, Teixeira P, Cotten A. T2 mapping of the sacroiliac joints with 3-T MRI: a preliminary study. AJR Am J Roentgenol. 2017;209:389–94.CrossRef
14.
go back to reference Pan J, Pialat J-B, Joseph T, et al. Knee cartilage T2 characteristics and evolution in relation to morphologic abnormalities detected at 3-T MR imaging: a longitudinal study of the normal control cohort from the osteoarthritis initiative. Radiology. 2011;261:507–15.CrossRef Pan J, Pialat J-B, Joseph T, et al. Knee cartilage T2 characteristics and evolution in relation to morphologic abnormalities detected at 3-T MR imaging: a longitudinal study of the normal control cohort from the osteoarthritis initiative. Radiology. 2011;261:507–15.CrossRef
15.
go back to reference Larbre JP, Da Silva JA, Moore AR, James IT, Scott DL, Willoughby DA. Cartilage contribution to gender differences in joint disease progression. A study with rat articular cartilage. Clin Exp Rheumatol. 1994;12:401–8.PubMed Larbre JP, Da Silva JA, Moore AR, James IT, Scott DL, Willoughby DA. Cartilage contribution to gender differences in joint disease progression. A study with rat articular cartilage. Clin Exp Rheumatol. 1994;12:401–8.PubMed
16.
go back to reference Felson D. Epidemiology of osteoarthritis. In: Brandt KD, Doherty M, Lohmander LS, editors. Osteoarthritis. New York: Oxford University Press; 1998. p. 13–22. Felson D. Epidemiology of osteoarthritis. In: Brandt KD, Doherty M, Lohmander LS, editors. Osteoarthritis. New York: Oxford University Press; 1998. p. 13–22.
17.
go back to reference Felson DT, Naimark A, Anderson J, Kazis L, Castelli W, Meenan RF. The prevalence of knee osteoarthritis in the elderly. The Framingham osteoarthritis study. Arthritis Rheum. 1987;30:914–8.CrossRef Felson DT, Naimark A, Anderson J, Kazis L, Castelli W, Meenan RF. The prevalence of knee osteoarthritis in the elderly. The Framingham osteoarthritis study. Arthritis Rheum. 1987;30:914–8.CrossRef
18.
go back to reference Mosher TJ, Collins CM, Smith HE, et al. Effect of gender on in vivo cartilage magnetic resonance imaging T2 mapping. J Magn Reson Imaging. 2004;19:323–8.CrossRef Mosher TJ, Collins CM, Smith HE, et al. Effect of gender on in vivo cartilage magnetic resonance imaging T2 mapping. J Magn Reson Imaging. 2004;19:323–8.CrossRef
19.
go back to reference Mosher TJ, Liu Y, Yang QX, et al. Age dependency of cartilage magnetic resonance imaging T2 relaxation times in asymptomatic women. Arthritis Rheum. 2004;50:2820–8.CrossRef Mosher TJ, Liu Y, Yang QX, et al. Age dependency of cartilage magnetic resonance imaging T2 relaxation times in asymptomatic women. Arthritis Rheum. 2004;50:2820–8.CrossRef
20.
go back to reference Lusse S, Claassen H, Gehrke T, et al. Evaluation of water content by spatially resolved transverse relaxation times of human articular cartilage. Magn Reson Imaging. 2000;18:423–30.CrossRef Lusse S, Claassen H, Gehrke T, et al. Evaluation of water content by spatially resolved transverse relaxation times of human articular cartilage. Magn Reson Imaging. 2000;18:423–30.CrossRef
21.
go back to reference Baum T, Joseph GB, Nardo L, et al. MRI-based knee cartilage T2 measurements and focal knee lesions correlate with BMI - 36 month follow-up data from the osteoarthritis initiative. Arthritis Care Res. 2013;65:23–33.CrossRef Baum T, Joseph GB, Nardo L, et al. MRI-based knee cartilage T2 measurements and focal knee lesions correlate with BMI - 36 month follow-up data from the osteoarthritis initiative. Arthritis Care Res. 2013;65:23–33.CrossRef
22.
go back to reference Doniselli FM, Albano D, Chianca V, Cimmino MA, Sconfienza LM. Gadolinium accumulation after contrast-enhanced magnetic resonance imaging: what rheumatologists should know. Clin Rheumatol. 2017;36:977–80.CrossRef Doniselli FM, Albano D, Chianca V, Cimmino MA, Sconfienza LM. Gadolinium accumulation after contrast-enhanced magnetic resonance imaging: what rheumatologists should know. Clin Rheumatol. 2017;36:977–80.CrossRef
23.
go back to reference Savarino E, Chianca V, Bodini G, et al. Gadolinium accumulation after contrast-enhanced magnetic resonance imaging: which implications in patients with Crohn’s disease? Dig Liver Dis. 2017;49:728–30.CrossRef Savarino E, Chianca V, Bodini G, et al. Gadolinium accumulation after contrast-enhanced magnetic resonance imaging: which implications in patients with Crohn’s disease? Dig Liver Dis. 2017;49:728–30.CrossRef
Metadata
Title
T2-mapping of the sacroiliac joints at 1.5 Tesla: a feasibility and reproducibility study
Authors
Domenico Albano
Vito Chianca
Renato Cuocolo
Rodolfo Bignone
Francesco Ciccia
Luca Maria Sconfienza
Massimo Midiri
Arturo Brunetti
Roberto Lagalla
Massimo Galia
Publication date
01-12-2018
Publisher
Springer Berlin Heidelberg
Published in
Skeletal Radiology / Issue 12/2018
Print ISSN: 0364-2348
Electronic ISSN: 1432-2161
DOI
https://doi.org/10.1007/s00256-018-2951-3

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