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Skeletal Radiology
Published in: Skeletal Radiology 8/2018

01-08-2018 | Scientific Article

Peripheral DXA measurement around ankle joint to diagnose osteoporosis as assessed by central DXA measurement

Authors: Ki Hyuk Sung, Young Choi, Gyeong Hee Cho, Chin Youb Chung, Moon Seok Park, Kyoung Min Lee

Published in: Skeletal Radiology | Issue 8/2018

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Abstract

Objective

This study evaluated the correlation between central and peripheral bone mineral density (BMD) of the ankle joint, using dual-energy X-ray absorptiometry (DXA). We also investigated whether peripheral ankle BMD could be used to identify individuals who were diagnosed with osteoporosis, using central DXA.

Methods

We recruited 134 volunteers aged 20–90 years who agreed to participate in this study. Central BMD of the lumbar spine and left femur, and peripheral BMD of the medial malleolus, distal tibia, lateral malleolus, and talus were measured with DXA.

Results

Among the peripheral sites of the ankle, the highest and lowest BMD were observed in the talus and lateral malleolus, respectively. All peripheral DXA measurements of the ankle joint were significantly correlated with central DXA measurements. There was a good correlation (r: 0.656–0.725) between peripheral and central BMD for the older age group (> 50 years), but fair-to-good correlation (r: 0.263–0.654) for the younger age group (< 50 years). The cut-off values for peripheral BMD of the ankle joint between osteoporosis and non-osteoporosis were 0.548 g/cm2 (sensitivity, 89.0%; specificity, 69.0%) for the medial malleolus, 0.626 g/cm2 (sensitivity, 83.3%; specificity, 82.8%) for the distal tibia, 0.47 g/cm2 (sensitivity, 100.0%; specificity, 65.5%) for the lateral malleolus, and 0.973 g/cm2 (sensitivity, 72.2%; specificity, 83.6%) for the talus (p < 0.001).

Conclusions

This study showed good correlation between peripheral BMD around ankle joint and central BMD for older age group. Further study is required to use the ankle DXA as a valid clinical tool for the diagnosis of osteoporosis and fracture risk assessment.
Appendix
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Metadata
Title
Peripheral DXA measurement around ankle joint to diagnose osteoporosis as assessed by central DXA measurement
Authors
Ki Hyuk Sung
Young Choi
Gyeong Hee Cho
Chin Youb Chung
Moon Seok Park
Kyoung Min Lee
Publication date
01-08-2018
Publisher
Springer Berlin Heidelberg
Published in
Skeletal Radiology / Issue 8/2018
Print ISSN: 0364-2348
Electronic ISSN: 1432-2161
DOI
https://doi.org/10.1007/s00256-018-2876-x

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