Skip to main content
Top
Published in: Skeletal Radiology 1/2016

01-01-2016 | Review Article

Melanotic schwannoma: an 11-year case series

Authors: Michael Khoo, Ian Pressney, Rikin Hargunani, Roberto Tirabosco

Published in: Skeletal Radiology | Issue 1/2016

Login to get access

Abstract

Melanotic or melanocytic schwannoma is a rare tumour usually involving spinal nerve roots but can also present at other anatomical locations. Although there are less than 200 cases reported, melanotic schwannomas can have distinctive imaging features but there is limited recent literature on its often characteristic radiological appearances. Recent publication of the largest case series thus far has suggested melanotic schwannoma to be a separate entity to other schwannomata and that its reclassification to a malignant lesion be under consideration. We present a case series over an 11-year period to highlight salient imaging features with reference to the current concerns regarding its malignant potential.
Literature
1.
go back to reference Millar WG. A malignant melanotic tumour of ganglion cells arising from a thoracic sympathetic ganglion. J Pathol Bacteriol. 1932;35:351–7.CrossRef Millar WG. A malignant melanotic tumour of ganglion cells arising from a thoracic sympathetic ganglion. J Pathol Bacteriol. 1932;35:351–7.CrossRef
2.
go back to reference Carney JA. Psammomatous melanotic schwannoma. a distinctive, heritable tumor with special associations, including cardiac myxoma and the Cushing syndrome: Am J Surg Pathol. 1990;14:206–22. Carney JA. Psammomatous melanotic schwannoma. a distinctive, heritable tumor with special associations, including cardiac myxoma and the Cushing syndrome: Am J Surg Pathol. 1990;14:206–22.
3.
go back to reference Akiyoshi T, Ueda Y, Yanai K, Yamaguchi H, Kawamoto M, Toyoda K, et al. Melanotic schwannoma of the pancreas: report of a case. Surg Today. 2004;34:550–3.CrossRefPubMed Akiyoshi T, Ueda Y, Yanai K, Yamaguchi H, Kawamoto M, Toyoda K, et al. Melanotic schwannoma of the pancreas: report of a case. Surg Today. 2004;34:550–3.CrossRefPubMed
4.
go back to reference Bendszus M, Urbach H, Wolf HK, Schramm J, Solymosi L. Magnetic resonance imaging of intraspinal melanotic schwannoma. Eur Radiol. 1998;8:1197.CrossRefPubMed Bendszus M, Urbach H, Wolf HK, Schramm J, Solymosi L. Magnetic resonance imaging of intraspinal melanotic schwannoma. Eur Radiol. 1998;8:1197.CrossRefPubMed
5.
go back to reference De Cerchio L, Contratti F, Fraioli MF. Dorsal dumb-bell melanotic schwannoma operated on by posterior and anterior approach: case report and a review of the literature. Eur Spine J. 2006;15:664–9.PubMedCentralCrossRefPubMed De Cerchio L, Contratti F, Fraioli MF. Dorsal dumb-bell melanotic schwannoma operated on by posterior and anterior approach: case report and a review of the literature. Eur Spine J. 2006;15:664–9.PubMedCentralCrossRefPubMed
7.
go back to reference Liessi G, Barbazza R, Sartori F, Sabbadin P, Scapinello A. CT and MR imaging of melanocytic schwannomas: report of three cases. Eur J Radiol. 1990;11:138–42.CrossRefPubMed Liessi G, Barbazza R, Sartori F, Sabbadin P, Scapinello A. CT and MR imaging of melanocytic schwannomas: report of three cases. Eur J Radiol. 1990;11:138–42.CrossRefPubMed
8.
go back to reference Marton E, Feletti A, Orvieto E, Longatti P. Dumbbell-shaped C-2 psammomatous melanotic malignant schwannoma: case report and review of the literature. J Neurosurg Spine. 2007;6:591–9.CrossRefPubMed Marton E, Feletti A, Orvieto E, Longatti P. Dumbbell-shaped C-2 psammomatous melanotic malignant schwannoma: case report and review of the literature. J Neurosurg Spine. 2007;6:591–9.CrossRefPubMed
9.
go back to reference Vallat-Decouvelaere AV, Wassef M, Lot G, Catala M, Moussalam M, Caruel N, et al. Spinal melanotic schwannoma: a tumour with poor prognosis. Histopathology. 1999;35:558–66.CrossRefPubMed Vallat-Decouvelaere AV, Wassef M, Lot G, Catala M, Moussalam M, Caruel N, et al. Spinal melanotic schwannoma: a tumour with poor prognosis. Histopathology. 1999;35:558–66.CrossRefPubMed
10.
go back to reference Yokota H, Isobe K, Murakami M, Kubosawa H, Uno T. Dumbbell-shaped nonpsammomatous malignant melanotic schwannoma of the cervical spinal root. Spine J Off J North Am Spine Soc. 2012;12:e14–7.CrossRef Yokota H, Isobe K, Murakami M, Kubosawa H, Uno T. Dumbbell-shaped nonpsammomatous malignant melanotic schwannoma of the cervical spinal root. Spine J Off J North Am Spine Soc. 2012;12:e14–7.CrossRef
11.
go back to reference Zhang H, Yang G, Chen H, Wei B, Ke Q, Guo H, et al. Clinicopathological, immunohistochemical, and ultrastructural study of 13 cases of melanotic schwannoma. Chin Med J (Engl). 2005;118:1451–61. Zhang H, Yang G, Chen H, Wei B, Ke Q, Guo H, et al. Clinicopathological, immunohistochemical, and ultrastructural study of 13 cases of melanotic schwannoma. Chin Med J (Engl). 2005;118:1451–61.
12.
go back to reference Bernd, WS, James, MW, Robert AE. Atlas of tumor pathology: tumors of the peripheral nervous system. 3rd ed. Washington, DC: Armed Forces Institute of Pathology; 1999. Bernd, WS, James, MW, Robert AE. Atlas of tumor pathology: tumors of the peripheral nervous system. 3rd ed. Washington, DC: Armed Forces Institute of Pathology; 1999.
13.
go back to reference Torres-Mora J, Dry S, Li X, Binder S, Amin M, Folpe AL. Malignant melanotic schwannian tumor: a clinicopathologic, immunohistochemical, and gene expression profiling study of 40 cases, with a proposal for the reclassification of “melanotic schwannoma”. Am J Surg Pathol. 2014;38:94–105.CrossRefPubMed Torres-Mora J, Dry S, Li X, Binder S, Amin M, Folpe AL. Malignant melanotic schwannian tumor: a clinicopathologic, immunohistochemical, and gene expression profiling study of 40 cases, with a proposal for the reclassification of “melanotic schwannoma”. Am J Surg Pathol. 2014;38:94–105.CrossRefPubMed
14.
go back to reference Buhl R, Barth H, Hugo HH, Mautner VF, Mehdorn HM. Intracranial and spinal melanotic schwannoma in the same patient. J Neurooncol. 2004;68:249–54.CrossRefPubMed Buhl R, Barth H, Hugo HH, Mautner VF, Mehdorn HM. Intracranial and spinal melanotic schwannoma in the same patient. J Neurooncol. 2004;68:249–54.CrossRefPubMed
15.
go back to reference Culhaci N, Dikicioĝlu E, Meteoğlu I, Boylu S. Multiple melanotic schwannoma. Ann Diagn Pathol. 2003;7:254–8.CrossRefPubMed Culhaci N, Dikicioĝlu E, Meteoğlu I, Boylu S. Multiple melanotic schwannoma. Ann Diagn Pathol. 2003;7:254–8.CrossRefPubMed
16.
go back to reference Höllinger P, Godoy N, Sturzenegger M. Magnetic resonance imaging findings in isolated spinal psammomatous melanotic schwannoma. J Neurol. 1999;246:1100–2.CrossRefPubMed Höllinger P, Godoy N, Sturzenegger M. Magnetic resonance imaging findings in isolated spinal psammomatous melanotic schwannoma. J Neurol. 1999;246:1100–2.CrossRefPubMed
Metadata
Title
Melanotic schwannoma: an 11-year case series
Authors
Michael Khoo
Ian Pressney
Rikin Hargunani
Roberto Tirabosco
Publication date
01-01-2016
Publisher
Springer Berlin Heidelberg
Published in
Skeletal Radiology / Issue 1/2016
Print ISSN: 0364-2348
Electronic ISSN: 1432-2161
DOI
https://doi.org/10.1007/s00256-015-2256-8

Other articles of this Issue 1/2016

Skeletal Radiology 1/2016 Go to the issue