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Published in: Skeletal Radiology 7/2014

01-07-2014 | Case Report

Atypical vertebral Paget’s disease

Authors: Constance Beaudouin, Anthony Dohan, Toufic Nasrallah, Caroline Parlier, Sébastien Touraine, Korng Ea, Rachid Kaci, Jean-Denis Laredo

Published in: Skeletal Radiology | Issue 7/2014

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Abstract

A 40-year-old Mauritanian man consulted for back pain. A computed tomography of the spine showed patchy sclerosis of the fifth and seventh thoracic vertebral bodies with normal neural arch of T5 and sclerosis and hypertrophy of the neural arch of T7, as well as diffuse sclerosis of the T11 vertebral body with a normal neural arch. At MRI, low signal-intensity on T1-weighted images and high signal-intensity on T2-weighted images involved the whole T5 and T7 vertebrae and the vertebral body of T11. Working diagnoses included metastatic disease and lymphoma, and a biopsy of T7 and then T11 was carried out. Both showed pathological findings very suggestive of Paget’s disease. Since CT is usually the more specific radiological examination in vertebral Paget’s disease, we thought it could be useful to report this atypical CT presentation (patchy sclerosis of the vertebral body without diffuse bone texture changes and isolated involvement of the vertebral body) of vertebral Paget’s disease.
Literature
1.
go back to reference Altman RD. Musculoskeletal manifestations of Paget’s disease of bone. Arthritis Rheum. 1980;23(10):1121–7.PubMedCrossRef Altman RD. Musculoskeletal manifestations of Paget’s disease of bone. Arthritis Rheum. 1980;23(10):1121–7.PubMedCrossRef
2.
go back to reference Resnick D. Diagnosis of bone and joint disorders. Philadelphia: Saunders; 1995. Resnick D. Diagnosis of bone and joint disorders. Philadelphia: Saunders; 1995.
3.
go back to reference Pestka JM, Seitz S, Zustin J, Puschel K, Amling M, Barvencik F. Paget disease of the spine: an evaluation of 101 patients with a histomorphometric analysis of 29 cases. Eur Spine J. 2012;21(5):999–1006.PubMedCentralPubMedCrossRef Pestka JM, Seitz S, Zustin J, Puschel K, Amling M, Barvencik F. Paget disease of the spine: an evaluation of 101 patients with a histomorphometric analysis of 29 cases. Eur Spine J. 2012;21(5):999–1006.PubMedCentralPubMedCrossRef
4.
go back to reference Maldague B, Malghem J. Radiological aspects of Paget’s disease of bone (author’s transl). J Belge Rhumatol Med Phys. 1974;29(5–6):293–321.PubMed Maldague B, Malghem J. Radiological aspects of Paget’s disease of bone (author’s transl). J Belge Rhumatol Med Phys. 1974;29(5–6):293–321.PubMed
5.
go back to reference Zlatkin MB, Lander PH, Hadjipavlou AG, Levine JS. Paget disease of the spine: CT with clinical correlation. Radiology. 1986;160(1):155–9.PubMed Zlatkin MB, Lander PH, Hadjipavlou AG, Levine JS. Paget disease of the spine: CT with clinical correlation. Radiology. 1986;160(1):155–9.PubMed
7.
go back to reference Dohan A, Parlier-Cuau C, Bourillon C, Petrover D, Bousson V, Chicheportiche V, et al. Vertebral involvement in Paget’s disease: CT and MR appearances of a mad bone. Chicago: Radiological Society of North America. 2011. Dohan A, Parlier-Cuau C, Bourillon C, Petrover D, Bousson V, Chicheportiche V, et al. Vertebral involvement in Paget’s disease: CT and MR appearances of a mad bone. Chicago: Radiological Society of North America. 2011.
8.
go back to reference Chretien J. Vertebral localizations of Paget disease. Ann Radiol (Paris). 1995;38(4):169–76. Chretien J. Vertebral localizations of Paget disease. Ann Radiol (Paris). 1995;38(4):169–76.
9.
go back to reference Vande Berg BC, Malghem J, Lecouvet FE, Maldague B. Magnetic resonance appearance of uncomplicated Paget’s disease of bone. Semin Musculoskelet Radiol. 2001;5(1):69–77.PubMedCrossRef Vande Berg BC, Malghem J, Lecouvet FE, Maldague B. Magnetic resonance appearance of uncomplicated Paget’s disease of bone. Semin Musculoskelet Radiol. 2001;5(1):69–77.PubMedCrossRef
10.
go back to reference Godefroy D, Chevrot A, Ranoux C, Horreard P, Moutounet J, Pallardy G. The posterior arch of the Paget’s ivory vertebra. Biopsy of six cases (author’s transl). J Radiol. 1980;61(10):611–4.PubMed Godefroy D, Chevrot A, Ranoux C, Horreard P, Moutounet J, Pallardy G. The posterior arch of the Paget’s ivory vertebra. Biopsy of six cases (author’s transl). J Radiol. 1980;61(10):611–4.PubMed
11.
go back to reference Maldague B, Malghem J. Radiological aspects of Paget’s disease of bone (author’s transl). Acta Orthop Belg. 1974;40(4):425–53.PubMed Maldague B, Malghem J. Radiological aspects of Paget’s disease of bone (author’s transl). Acta Orthop Belg. 1974;40(4):425–53.PubMed
12.
go back to reference Smith SE, Murphey MD, Motamedi K, Mulligan ME, Resnik CS, Gannon FH. From the archives of the AFIP. Radiologic spectrum of Paget disease of bone and its complications with pathologic correlation. Radiographics. 2002;22(5):1191–216.PubMedCrossRef Smith SE, Murphey MD, Motamedi K, Mulligan ME, Resnik CS, Gannon FH. From the archives of the AFIP. Radiologic spectrum of Paget disease of bone and its complications with pathologic correlation. Radiographics. 2002;22(5):1191–216.PubMedCrossRef
13.
go back to reference Sprecher S, Steinberg R, Lichtenstein D, Witt KM, Barginear M. Magnetic resonance imaging presentation of lytic Paget’s disease of the cervical spine. J Bone Miner Res. 2002;17(11):1929–30.PubMedCrossRef Sprecher S, Steinberg R, Lichtenstein D, Witt KM, Barginear M. Magnetic resonance imaging presentation of lytic Paget’s disease of the cervical spine. J Bone Miner Res. 2002;17(11):1929–30.PubMedCrossRef
14.
go back to reference Steinbach LS, Johnston JO. Case report 777. Osteolytic Paget’s disease of the fifth lumbar vertebra. Skeletal Radiol. 1993;22(3):203–5.PubMedCrossRef Steinbach LS, Johnston JO. Case report 777. Osteolytic Paget’s disease of the fifth lumbar vertebra. Skeletal Radiol. 1993;22(3):203–5.PubMedCrossRef
15.
go back to reference Rosen MA, Wesolowski DP, Herkowitz HN. Osteolytic monostotic Paget’s disease of the axis. A case report. Spine. 1988;13:125–7.PubMedCrossRef Rosen MA, Wesolowski DP, Herkowitz HN. Osteolytic monostotic Paget’s disease of the axis. A case report. Spine. 1988;13:125–7.PubMedCrossRef
Metadata
Title
Atypical vertebral Paget’s disease
Authors
Constance Beaudouin
Anthony Dohan
Toufic Nasrallah
Caroline Parlier
Sébastien Touraine
Korng Ea
Rachid Kaci
Jean-Denis Laredo
Publication date
01-07-2014
Publisher
Springer Berlin Heidelberg
Published in
Skeletal Radiology / Issue 7/2014
Print ISSN: 0364-2348
Electronic ISSN: 1432-2161
DOI
https://doi.org/10.1007/s00256-013-1799-9

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