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Skeletal Radiology
Published in: Skeletal Radiology 5/2013

01-05-2013 | Review Article

The imaging of cartilaginous bone tumours. II. Chondrosarcoma

Authors: H. Douis, A. Saifuddin

Published in: Skeletal Radiology | Issue 5/2013

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Abstract

Chondrosarcoma is the third most common primary malignant bone tumour. There are various histological subtypes of chondrosarcomas, of which conventional intramedullary chondrosarcoma is by far the most common. Rarer sub-types include clear cell chondrosarcoma, myxoid chondrosarcoma, mesenchymal chondrosarcoma and dedifferentiated chondrosarcoma. Chondrosarcoma is also classified into central, peripheral and periosteal, dependent upon the lesion site, and into primary chondrosarcoma if the lesion arises de novo and secondary chondrosarcoma if the tumour arises in a pre-existing lesion. The various subtypes of chondrosarcoma have characteristic imaging features that may aid diagnosis and may guide biopsy, therefore potentially preventing misdiagnosis. The aim of this article is to provide an overview of the pertinent clinical and imaging findings of the different forms of chondrosarcoma.
Literature
1.
Brien EW, Mirra JM, Kerr R. Benign and malignant cartilage tumors of bone and joint: their anatomic and theoretical basis with an emphasis on radiology, pathology and clinical biology. I. The intramedullary cartilage tumors. Skeletal Radiol. 1997;26:325–53.PubMedCrossRef
2.
Marco RA, Gitelis S, Brebach GT, Healey JH. Cartilage tumors: evaluation and treatment. J Am Acad Orthop Surg. 2000;8:292–304.PubMed
3.
Flemming DJ, Murphey MD. Enchondroma and chondrosarcoma. Semin Musculoskelet Radiol. 2000;4:59–71.PubMedCrossRef
4.
Aigner T. Towards a new understanding and classification of chondrogenic neoplasias of the skeleton—biochemistry and cell biology of chondrosarcoma and its variants. Virchows Arch. 2002;441:219–30.PubMedCrossRef
5.
Murphey MD, Walker EA, Wilson AJ, Kransdorf MJ, Temple HT, Gannon FH. From the archives of the AFIP: imaging of primary chondrosarcoma: radiologic–pathologic correlation. Radiographics. 2003;23:1245–78.PubMedCrossRef
6.
Ahmed AR, Tan TS, Unni KK, Collins MS, Wenger DE, Sim FH. Secondary chondrosarcoma in osteochondroma: report of 107 patients. Clin Orthop Relat Res. 2003;193–206.
7.
Altay M, Bayrakci K, Yildiz Y, Erekul S, Saglik Y. Secondary chondrosarcoma in cartilage bone tumors: report of 32 patients. J Orthop Sci. 2007;12:415–23.PubMedCrossRef
8.
Bovee JV, van Roggen JF, Cleton-Jansen AM, Taminiau AH, van der Woude HJ, Hogendoorn PC. Malignant progression in multiple enchondromatosis (Ollier’s disease): an autopsy-based molecular genetic study. Hum Pathol. 2000;31:1299–303.PubMedCrossRef
9.
Shah ZK, Peh WC, Wong Y, Shek TW, Davies AM. Sarcomatous transformation in diaphyseal aclasis. Australas Radiol. 2007;51:110–9.PubMedCrossRef
10.
Skeletal Lesions Interobserver Correlation among Expert Diagnosticians (SLICED) Study Group. Reliability of histopathologic and radiologic grading of cartilaginous neoplasms in long bones. J Bone Joint Surg Am. 2007;89:2113–23.CrossRef
11.
Eefting D, Schrage YM, Geirnaerdt MJ, Le Cessie S, Taminiau AH, Bovee JV, et al. Assessment of interobserver variability and histologic parameters to improve reliability in classification and grading of central cartilaginous tumors. Am J Surg Pathol. 2009;33:50–7.PubMedCrossRef
12.
Reith JD, Horodyski MB, Scarborough MT. Grade 2 chondrosarcoma: stage I or stage II tumor? Clin Orthop Relat Res. 2003;45–51.
13.
O’Connor MI, Bancroft LW. Benign and malignant cartilage tumors of the hand. Hand Clin. 2004;20:317–23. vi.PubMedCrossRef
14.
Patil S, de Silva MV, Crossan J, Reid R. Chondrosarcoma of the bones of the feet. J Foot Ankle Surg. 2003;42:290–5.PubMedCrossRef
15.
Duarte MP, Maldjian C, Katta US, Kenan S. Conventional intramedullary chondrosarcoma with subarticular involvement. Clin Imaging. 2008;32:69–72.PubMedCrossRef
16.
Douis H, James SL, Grimer RJ, Davies MA. Is bone scintigraphy necessary in the initial surgical staging of chondrosarcoma of bone? Skeletal Radiol. 2012;41:429–36.PubMedCrossRef
17.
Leerapun T, Hugate RR, Inwards CY, Scully SP, Sim FH. Surgical management of conventional grade I chondrosarcoma of long bones. Clin Orthop Relat Res. 2007;463:166–72.PubMed
18.
Jones K, Pacella J, Kirby AD, Pervez N. Unusual behaviour of low-grade chondrosarcoma of bone. J Med Imaging Radiat Oncol. 2008;52:95–6.PubMedCrossRef
19.
Damron TA, Ward WG, Stewart A. Osteosarcoma, chondrosarcoma, and Ewing’s sarcoma: National Cancer Data Base report. Clin Orthop Relat Res. 2007;459:40–7.PubMedCrossRef
20.
Schwab JH, Wenger D, Unni K, Sim FH. Does local recurrence impact survival in low-grade chondrosarcoma of the long bones? Clin Orthop Relat Res. 2007;462:175–80.PubMedCrossRef
21.
Fong YC, Pairolero PC, Sim FH, Cha SS, Blanchard CL, Scully SP. Chondrosarcoma of the chest wall: a retrospective clinical analysis. Clin Orthop Relat Res. 2004;184–9.
22.
Pant R, Yasko AW, Lewis VO, Raymond K, Lin PP. Chondrosarcoma of the scapula: long-term oncologic outcome. Cancer. 2005;104:149–58.PubMedCrossRef
23.
Jawad MU, Haleem AA, Scully SP. Malignant sarcoma of the pelvic bones: treatment outcomes and prognostic factors vary by histopathology. Cancer. 2011;117:1529–41.PubMedCrossRef
24.
Pring ME, Weber KL, Unni KK, Sim FH. Chondrosarcoma of the pelvis. A review of sixty-four cases. J Bone Joint Surg Am. 2001;83-A:1630–42.PubMed
25.
Schneiderbauer MM, Blanchard C, Gullerud R, Harmsen WS, Rock MG, Shives TC, et al. Scapular chondrosarcomas have high rates of local recurrence and metastasis. Clin Orthop Relat Res. 2004;232–8.
26.
Giuffrida AY, Burgueno JE, Koniaris LG, Gutierrez JC, Duncan R, Scully SP. Chondrosarcoma in the United States (1973 to 2003): an analysis of 2890 cases from the SEER database. J Bone Joint Surg Am. 2009;91:1063–72.PubMedCrossRef
27.
Bramer JA, Abudu AA, Grimer RJ, Carter SR, Tillman RM. Do pathological fractures influence survival and local recurrence rate in bony sarcomas? Eur J Cancer. 2007;43:1944–51.PubMedCrossRef
28.
Ehara S, Nakayama T, Nishida J, Shiraishi H, Yoshioka H, Aoki J. Bone scintigraphic and CT evaluation of chondrosarcoma of the rib: correlation with histological grade in 6 cases. Ann Nucl Med. 2004;18:633–6.PubMedCrossRef
29.
Feldman F, Van Heertum R, Saxena C, Parisien M. 18FDG-PET applications for cartilage neoplasms. Skeletal Radiol. 2005;34:367–74.PubMedCrossRef
30.
Brenner W, Conrad EU, Eary JF. FDG PET imaging for grading and prediction of outcome in chondrosarcoma patients. Eur J Nucl Med Mol Imaging. 2004;31:189–95.PubMedCrossRef
31.
Yoo HJ, Hong SH, Choi JY, Moon KC, Kim HS, Choi JA, et al. Differentiating high-grade from low-grade chondrosarcoma with MR imaging. Eur Radiol. 2009;19:3008–14.PubMedCrossRef
32.
Collins MS, Koyama T, Swee RG, Inwards CY. Clear cell chondrosarcoma: radiographic, computed tomographic, and magnetic resonance findings in 34 patients with pathologic correlation. Skeletal Radiol. 2003;32:687–94.PubMedCrossRef
33.
Itala A, Leerapun T, Inwards C, Collins M, Scully SP. An institutional review of clear cell chondrosarcoma. Clin Orthop Relat Res. 2005;440:209–12.PubMedCrossRef
34.
Donati D, Yin JQ, Colangeli M, Colangeli S, Bella CD, Bacchini P, et al. Clear cell chondrosarcoma of bone: long time follow-up of 18 cases. Arch Orthop Trauma Surg. 2008;128:137–42.PubMedCrossRef
35.
Kaim AH, Hugli R, Bonel HM, Jundt G. Chondroblastoma and clear cell chondrosarcoma: radiological and MRI characteristics with histopathological correlation. Skeletal Radiol. 2002;31:88–95.PubMedCrossRef
36.
Memis A, Arkun R, Basdemir G, Sabah D, Ustun EE. Clear cell chondrosarcoma: unusual radiologic appearances with histologic correlation. Eur Radiol. 2002;12:427–30.PubMedCrossRef
37.
Corradi D, Bacchini P, Campanini N, Bertoni F. Aggressive clear cell chondrosarcomas: do distinctive characteristics exist?: a report of 4 cases. Arch Pathol Lab Med. 2006;130:1673–9.PubMed
38.
Kalil RK, Inwards CY, Unni KK, Bertoni F, Bacchini P, Wenger DE, et al. Dedifferentiated clear cell chondrosarcoma. Am J Surg Pathol. 2000;24:1079–86.PubMedCrossRef
39.
Cesari M, Bertoni F, Bacchini P, Mercuri M, Palmerini E, Ferrari S. Mesenchymal chondrosarcoma. An analysis of patients treated at a single institution. Tumori. 2007;93:423–7.PubMed
40.
Littrell LA, Wenger DE, Wold LE, Bertoni F, Unni KK, White LM, et al. Radiographic, CT, and MR imaging features of dedifferentiated chondrosarcomas: a retrospective review of 174 de novo cases. Radiographics. 2004;24:1397–409.PubMedCrossRef
41.
Staals EL, Bacchini P, Bertoni F. Dedifferentiated central chondrosarcoma. Cancer. 2006;106:2682–91.PubMedCrossRef
42.
Okada K, Hasegawa T, Tateishi U, Endo M, Itoi E. Dedifferentiated chondrosarcoma with telangiectatic osteosarcoma-like features. J Clin Pathol. 2006;59:1200–2.PubMedCrossRef
43.
Estrada EG, Ayala AG, Lewis V, Czerniak B. Dedifferentiated chondrosarcoma with a noncartilaginous component mimicking a conventional giant cell tumor of bone. Ann Diagn Pathol. 2002;6:159–63.PubMedCrossRef
44.
Grimer RJ, Gosheger G, Taminiau A, Biau D, Matejovsky Z, Kollender Y, et al. Dedifferentiated chondrosarcoma: prognostic factors and outcome from a European group. Eur J Cancer. 2007;43:2060–5.PubMedCrossRef
45.
Dickey ID, Rose PS, Fuchs B, Wold LE, Okuno SH, Sim FH, et al. Dedifferentiated chondrosarcoma: the role of chemotherapy with updated outcomes. J Bone Joint Surg Am. 2004;86-A:2412–8.PubMed
46.
Mitchell AD, Ayoub K, Mangham DC, Grimer RJ, Carter SR, Tillman RM. Experience in the treatment of dedifferentiated chondrosarcoma. J Bone Joint Surg Br. 2000;82:55–61.PubMedCrossRef
47.
MacSweeney F, Darby A, Saifuddin A. Dedifferentiated chondrosarcoma of the appendicular skeleton: MRI-pathological correlation. Skeletal Radiol. 2003;32:671–8.PubMedCrossRef
48.
Saifuddin A, Mann BS, Mahroof S, Pringle JA, Briggs TW, Cannon SR. Dedifferentiated chondrosarcoma: use of MRI to guide needle biopsy. Clin Radiol. 2004;59:268–72.PubMedCrossRef
49.
Brien EW, Mirra JM, Luck Jr JV. Benign and malignant cartilage tumors of bone and joint: their anatomic and theoretical basis with an emphasis on radiology, pathology and clinical biology. II. Juxtacortical cartilage tumors. Skeletal Radiol. 1999;28:1–20.PubMedCrossRef
50.
Robinson P, White LM, Sundaram M, Kandel R, Wunder J, McDonald DJ, et al. Periosteal chondroid tumors: radiologic evaluation with pathologic correlation. AJR Am J Roentgenol. 2001;177:1183–8.PubMedCrossRef
51.
Vanel D, De Paolis M, Monti C, Mercuri M, Picci P. Radiological features of 24 periosteal chondrosarcomas. Skeletal Radiol. 2001;30:208–12.PubMedCrossRef
52.
Papagelopoulos PJ, Galanis EC, Mavrogenis AF, Savvidou OD, Bond JR, Unni KK, et al. Survivorship analysis in patients with periosteal chondrosarcoma. Clin Orthop Relat Res. 2006;448:199–207.PubMedCrossRef
53.
Chaabane S, Bouaziz MC, Drissi C, Abid L, Ladeb MF. Periosteal chondrosarcoma. AJR Am J Roentgenol. 2009;192:W1–6.PubMedCrossRef
54.
Murphey MD, Choi JJ, Kransdorf MJ, Flemming DJ, Gannon FH. Imaging of osteochondroma: variants and complications with radiologic–pathologic correlation. Radiographics. 2000;20:1407–34.PubMed
55.
Staals EL, Bacchini P, Mercuri M, Bertoni F. Dedifferentiated chondrosarcomas arising in preexisting osteochondromas. J Bone Joint Surg Am. 2007;89:987–93.PubMedCrossRef
56.
Lee KC, Davies AM, Cassar-Pullicino VN. Imaging the complications of osteochondromas. Clin Radiol. 2002;57:18–28.PubMedCrossRef
57.
Woertler K, Lindner N, Gosheger G, Brinkschmidt C, Heindel W. Osteochondroma: MR imaging of tumor-related complications. Eur Radiol. 2000;10:832–40.PubMedCrossRef
58.
Feldman F, Vanheertum R, Saxena C. 18fluoro-deoxyglucose positron emission tomography evaluation of benign versus malignant osteochondromas: preliminary observations. J Comput Assist Tomogr. 2006;30:858–64.PubMedCrossRef
59.
Bernard SA, Murphey MD, Flemming DJ, Kransdorf MJ. Improved differentiation of benign osteochondromas from secondary chondrosarcomas with standardized measurement of cartilage cap at CT and MR imaging. Radiology. 2010;255:857–65.PubMedCrossRef
Metadata
Title
The imaging of cartilaginous bone tumours. II. Chondrosarcoma
Authors
H. Douis
A. Saifuddin
Publication date
01-05-2013
Publisher
Springer-Verlag
Published in
Skeletal Radiology / Issue 5/2013
Print ISSN: 0364-2348
Electronic ISSN: 1432-2161
DOI
https://doi.org/10.1007/s00256-012-1521-3

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