Skip to main content
Top
Published in: Skeletal Radiology 1/2011

01-01-2011 | Case Report

Bone metastasis of glandular cardiac myxoma mimicking a metastatic carcinoma

Authors: Shantveer G. Uppin, Nirmala Jambhekar, Ajay Puri, Rajiv Kumar, Manish Agarwal, Darshana Sanghvi

Published in: Skeletal Radiology | Issue 1/2011

Login to get access

Abstract

Skeletal metastasis from a cardiac myxoma is rare. We describe an extremely unusual case of a cardiac myxoma metastasing to the femur in a 46-year-old female presenting with pain in the right hip. Radiographs showed an expansile lytic lesion with pathological fracture involving the neck and proximal shaft of the right femur. Histology revealed features of cardiac myxoma with heterologous glandular elements, which was initially mistaken for a metastatic mucin-secreting adenocarcinoma.
Literature
1.
go back to reference Molina JE, Edwards JE, Ward HB. Primary cardiac tumors: experience at the University of Minnesota. Thorac Cardiovasc Surg. 1990;38 Suppl 2:183–91.CrossRefPubMed Molina JE, Edwards JE, Ward HB. Primary cardiac tumors: experience at the University of Minnesota. Thorac Cardiovasc Surg. 1990;38 Suppl 2:183–91.CrossRefPubMed
2.
go back to reference Nielsen GP, O’Connell JX, Rosenberg AE. Intramuscular myxoma: a clinicopathologic study of 51 cases with emphasis on hypercellular and hypervascular variants. Am J Surg Pathol. 1998;22:1222–7.CrossRefPubMed Nielsen GP, O’Connell JX, Rosenberg AE. Intramuscular myxoma: a clinicopathologic study of 51 cases with emphasis on hypercellular and hypervascular variants. Am J Surg Pathol. 1998;22:1222–7.CrossRefPubMed
3.
go back to reference Ghose BC, Huvos AG, Gerold FP, Miller TR. Myxoma of the jaw bones. Cancer. 1973;31:237–40.CrossRef Ghose BC, Huvos AG, Gerold FP, Miller TR. Myxoma of the jaw bones. Cancer. 1973;31:237–40.CrossRef
4.
go back to reference Burke AP, Tazelaaar H, Gomez-Roman JJ, et al. Benign tumors of pluripotent mesenchyme. In: Travis WD, Brambilla E, Muller-Hermelimk HK, Harris CC, editors. World Health Organisation Classification of Tumors. Pathology and Genetics of Tumors of Lung, Pleura, Thymus and Heart. 2nd ed. Lyon, France: IARC Press; 2004. p. 260–3. Burke AP, Tazelaaar H, Gomez-Roman JJ, et al. Benign tumors of pluripotent mesenchyme. In: Travis WD, Brambilla E, Muller-Hermelimk HK, Harris CC, editors. World Health Organisation Classification of Tumors. Pathology and Genetics of Tumors of Lung, Pleura, Thymus and Heart. 2nd ed. Lyon, France: IARC Press; 2004. p. 260–3.
5.
go back to reference Gray IR, Williams WG. Recurring cardiac myxoma. Br Med J. 1985;53:645–9. Gray IR, Williams WG. Recurring cardiac myxoma. Br Med J. 1985;53:645–9.
6.
go back to reference Hannah H, Eisemann G, Hiszezynskyj R, Winsky M, Cohen L. Invasive atrial myxoma: documentation of malignant potential of cardiac myxomas. Am Heart J. 1982;104:881–3.CrossRefPubMed Hannah H, Eisemann G, Hiszezynskyj R, Winsky M, Cohen L. Invasive atrial myxoma: documentation of malignant potential of cardiac myxomas. Am Heart J. 1982;104:881–3.CrossRefPubMed
7.
go back to reference Hou YC, Chang S, Lo HM, Hsiao CH, Lin FY. Recurrent cardiac myxoma with multiple distant metastasis and malignant change. J Formos Med Assoc. 2001;100:63–5.PubMed Hou YC, Chang S, Lo HM, Hsiao CH, Lin FY. Recurrent cardiac myxoma with multiple distant metastasis and malignant change. J Formos Med Assoc. 2001;100:63–5.PubMed
8.
go back to reference Burke AP, Virmani R. Myxoma. A clinicopathologic study. Am J Clin Pathol. 1993;10:671–80. Burke AP, Virmani R. Myxoma. A clinicopathologic study. Am J Clin Pathol. 1993;10:671–80.
9.
go back to reference Goldman BI, Frydman C, Harpaz N, Ryan SF, Loiterman D. Glandular cardiac myxomas. Histologic, immunohistochemical, and ultrastructural evidence of epithelial differentiation. Cancer. 1987;59:1767–75.CrossRefPubMed Goldman BI, Frydman C, Harpaz N, Ryan SF, Loiterman D. Glandular cardiac myxomas. Histologic, immunohistochemical, and ultrastructural evidence of epithelial differentiation. Cancer. 1987;59:1767–75.CrossRefPubMed
10.
go back to reference Pucci A, Gagliardotto P, Zanini C, Pansini S, di Summa M, Mollo F. Histopathologic and clinical characterization of cardiac myxoma: a review of 53 cases from a single institution. Am Heart J. 2000;140:134–8.CrossRefPubMed Pucci A, Gagliardotto P, Zanini C, Pansini S, di Summa M, Mollo F. Histopathologic and clinical characterization of cardiac myxoma: a review of 53 cases from a single institution. Am Heart J. 2000;140:134–8.CrossRefPubMed
11.
go back to reference Rosai J. Rosai and Ackerman’s Surgical Pathology. 9th ed. St. Louis: Mosby; 2004. Rosai J. Rosai and Ackerman’s Surgical Pathology. 9th ed. St. Louis: Mosby; 2004.
12.
go back to reference McClure DK, Dahlin DC. Myxoma of bone. Report of three cases. Mayo Clin Proc. 1977;52:249–53.PubMed McClure DK, Dahlin DC. Myxoma of bone. Report of three cases. Mayo Clin Proc. 1977;52:249–53.PubMed
13.
go back to reference Hill JA, Victor TA, Dawson JW, Milgram JW. Myxoma of toe. J Bone J Surg. 1978;60:128–30. Hill JA, Victor TA, Dawson JW, Milgram JW. Myxoma of toe. J Bone J Surg. 1978;60:128–30.
15.
go back to reference Sundaram M, Janney C, McDonald DJ. Myxoma of the humerus: an exceptional site of origin. Skeletal Radiol. 2000;29:57–60.CrossRefPubMed Sundaram M, Janney C, McDonald DJ. Myxoma of the humerus: an exceptional site of origin. Skeletal Radiol. 2000;29:57–60.CrossRefPubMed
16.
go back to reference Read RC, White HJ, Murphy ML, William D, Sun CN, Flanagan WH. The malignant potentiality of left atrial myxoma. J Thorac Cardiovasc Surg. 1974;68:857–68.PubMed Read RC, White HJ, Murphy ML, William D, Sun CN, Flanagan WH. The malignant potentiality of left atrial myxoma. J Thorac Cardiovasc Surg. 1974;68:857–68.PubMed
17.
go back to reference Jungreis CA, Sekhar LN, Martinez AJ, Hirsch BE. Cardiac myxoma metastatic to temporal bone. Radiology. 1989;170:244.PubMed Jungreis CA, Sekhar LN, Martinez AJ, Hirsch BE. Cardiac myxoma metastatic to temporal bone. Radiology. 1989;170:244.PubMed
18.
go back to reference Moran C, Braunstein EM, Ulbright T, Colyer RA. Case report 689. Metastatic atrial myxoma to the pubis. Skeletal Radiol. 1991;20:465–7.CrossRefPubMed Moran C, Braunstein EM, Ulbright T, Colyer RA. Case report 689. Metastatic atrial myxoma to the pubis. Skeletal Radiol. 1991;20:465–7.CrossRefPubMed
19.
go back to reference Rupp GM, Heyman RA, Martinez AJ, Sekhar LN, Jungreis CA. The pathology of metastatic cardiac myxoma. Am J Clin Pathol. 1989;91:221–7.PubMed Rupp GM, Heyman RA, Martinez AJ, Sekhar LN, Jungreis CA. The pathology of metastatic cardiac myxoma. Am J Clin Pathol. 1989;91:221–7.PubMed
20.
go back to reference Carney JA, Hruska L, Beauchamp GD. Dominant inheritance of the complex of myxomas, spotty pigmentation and endocrine overactivity. Mayo Clin Proc. 1986;61:165–72.PubMed Carney JA, Hruska L, Beauchamp GD. Dominant inheritance of the complex of myxomas, spotty pigmentation and endocrine overactivity. Mayo Clin Proc. 1986;61:165–72.PubMed
21.
go back to reference Carney JA, Boccon-Gibod L, Jarka DE, et al. Osteochondromyxoma of bone: a congenital tumor associated with lentigines and other unusual disorders. Am J Surg Pathol. 2001;25:164–76.CrossRefPubMed Carney JA, Boccon-Gibod L, Jarka DE, et al. Osteochondromyxoma of bone: a congenital tumor associated with lentigines and other unusual disorders. Am J Surg Pathol. 2001;25:164–76.CrossRefPubMed
22.
go back to reference Johansson L. Histogenesis of cardiac myxoma: an immunohistochemical study of 19 cases, including one with glandular structures, and review of literature. Arch Path Lab Med. 1989;113:735–41.PubMed Johansson L. Histogenesis of cardiac myxoma: an immunohistochemical study of 19 cases, including one with glandular structures, and review of literature. Arch Path Lab Med. 1989;113:735–41.PubMed
23.
go back to reference Moiyadi AV, Moiyadi AA, Sampath S, et al. Intracranial metastasis from a glandular variant of atrial myxoma. Acta Neurochir (Wien). 2007;149:1157–62.CrossRef Moiyadi AV, Moiyadi AA, Sampath S, et al. Intracranial metastasis from a glandular variant of atrial myxoma. Acta Neurochir (Wien). 2007;149:1157–62.CrossRef
Metadata
Title
Bone metastasis of glandular cardiac myxoma mimicking a metastatic carcinoma
Authors
Shantveer G. Uppin
Nirmala Jambhekar
Ajay Puri
Rajiv Kumar
Manish Agarwal
Darshana Sanghvi
Publication date
01-01-2011
Publisher
Springer-Verlag
Published in
Skeletal Radiology / Issue 1/2011
Print ISSN: 0364-2348
Electronic ISSN: 1432-2161
DOI
https://doi.org/10.1007/s00256-010-0966-5

Other articles of this Issue 1/2011

Skeletal Radiology 1/2011 Go to the issue