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Skeletal Radiology
Published in: Skeletal Radiology 12/2008

01-12-2008 | Scientific Article

Diffusion-weighted MRI of denervated muscle: a clinical and experimental study

Authors: Nathalie Holl, Andoni Echaniz-Laguna, Guillaume Bierry, Michel Mohr, Jean-Philippe Loeffler, Thomas Moser, Jean-Louis Dietemann, Stéphane Kremer

Published in: Skeletal Radiology | Issue 12/2008

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Abstract

Objective

The aim of this study was to investigate skeletal muscle denervation using diffusion-weighted magnetic resonance imaging (DWMRI).

Materials and methods

Sciatic nerve axotomy was performed in a group of nine New Zealand White rabbits, and electromyographic (EMG), pathological, and DWMRI studies were conducted on ipsilateral hamstring muscles 1 and 8 days after axotomy. In addition, DWMRI studies were carried out on leg muscles of ten patients with acute and subacute lumbosacral radiculopathy.

Results

High intensity signals on short tau inversion recovery (STIR) magnetic resonance imaging and an increased apparent diffusion coefficient (ADC) were observed in denervated muscles of the animals 1 and 8 days after axotomy as well as in denervated muscles of the patients with radiculopathy. In the clinical study, ADC was 1.26 ± 0.18 × 10−9 m2/s in normal muscle and increased to 1.56 ± 0.23 × 10−9 m2/s in denervated muscles (p = 0.0016). In animals, EMG and muscle pathological studies were normal 1 day after axotomy, and the muscles demonstrated spontaneous activity on EMG and neurogenic atrophy on histological studies 7 days later.

Conclusion

This DWMRI study demonstrates that enlargement of extracellular fluid space in muscle denervation is an early phenomenon occurring several days before the appearance of EMG and histological abnormalities.
Appendix
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Metadata
Title
Diffusion-weighted MRI of denervated muscle: a clinical and experimental study
Authors
Nathalie Holl
Andoni Echaniz-Laguna
Guillaume Bierry
Michel Mohr
Jean-Philippe Loeffler
Thomas Moser
Jean-Louis Dietemann
Stéphane Kremer
Publication date
01-12-2008
Publisher
Springer Berlin Heidelberg
Published in
Skeletal Radiology / Issue 12/2008
Print ISSN: 0364-2348
Electronic ISSN: 1432-2161
DOI
https://doi.org/10.1007/s00256-008-0552-2

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