Top

Published in:

01-04-2008 | Case Report

Dedifferentiated parosteal osteosarcoma with giant cell tumor component

Authors: Diana M. Cardona, Jacquelyn A. Knapik, John D. Reith

Published in: Skeletal Radiology | Issue 4/2008

Abstract

Dedifferentiated parosteal osteosarcoma is characterized histologically by the admixture of low-grade fibroblastic osteosarcoma and a high-grade component typically resembling conventional osteosarcoma or malignant fibrous histiocytoma. We report an unusual distal femoral dedifferentiated parosteal osteosarcoma in which the dedifferentiated component resembled a giant cell tumor of bone. This phenotype is rarely described in the dedifferentiated component of a dedifferentiated parosteal osteosarcoma. The clinical, radiographic, and pathologic features of this unusual tumor are described to further expand the histologic spectrum of dedifferentiated parosteal osteosarcoma.

Dei Tos AP, Pedeutour F. Dedifferentiated liposarcoma. In: Fletcher CDM, Unni KK, Mertens F, editors. Pathology and genetics. Tumours of soft tissue and bone. Lyon: IARC; 2002. p. 38–39.

Milchgrub S, Hogendoorn P. Dedifferentiated chondrosarcoma. In: Fletcher CDM, Unni KK, Mertens F, editors. Pathology and genetics. Tumours of soft tissue and bone. Lyon: IARC; 2002. p. 252–254.

Unni KK, Knuutila S. Parosteal osteosarcoma. In: Fletcher CDM, Unni KK, Mertens F, editors. Pathology and genetics. Tumours of soft tissue and bone. Lyon: IARC; 2002. p. 279–281.

Reith JD, Donahue FI, Hornicek FJ. Dedifferentiated parosteal osteosarcoma with rhabdomyosarcomatous differentiation. Skeletal Radiol 1999; 28: 527–531.PubMedCrossRef

Wines A, Bonar F, Lam P, et al. Telangiectatic dedifferentiation of a parosteal osteosarcoma. Skeletal Radiol 2000; 29: 597–600.PubMedCrossRef

Estrada E, Ayala A, Valerie L, Czerniak B. Dedifferentiated chondrosarcoma with a noncartilaginous component mimicking a conventional giant cell tumor of bone. Ann Diagn Pathol 2002; 6: 159–163.PubMedCrossRef

Ishida T, Dorfman HD, Habermann ET. Dedifferentiated chondrosarcoma of humerus with giant cell tumor-like features. Skeletal Radiol 1995; 24: 76–80.PubMedCrossRef

Mirra JM. Bone tumors. Clinical, radiologic, and pathologic correlations. Philadelphia: Lea and Febiger, 1989.

Sissons HA, Matlen JA, Lewis MM. Dedifferentiated chondrosarcoma. Report of an unusual case. J Bone Joint Surg Am 1991; 73: 294–300.PubMed

10.

Bertoni F, Bacchini P, Staals EL, Davidovitz P. Dedifferentiated parosteal osteosarcoma: the experience of the Rizzoli Institute. Cancer 2005; 103: 2373–2382.PubMedCrossRef

11.

Dahlin DC, Unni KK. Bone tumors. Springfield: Thomas, 1986.

12.

Shuhaibar H, Friedman L. Dedifferentiated parosteal osteosarcoma with high-grade osteoclast-rich osteogenic sarcoma at presentation. Skeletal Radiol 1998; 27: 574–577.PubMedCrossRef

13.

Wold LE, Unni KK, Beabout JW, Sim FH, Dahlin DC. Dedifferentiated parosteal osteosarcoma. J Bone Joint Surg Am 1984; 66: 53–59.PubMed

14.

Dunham WK, Wilborn WH, Zarzour RJ. A large parosteal osteosarcoma with transformation to high-grade osteosarcoma. A case report. Cancer 1979; 44: 1495–1500.PubMedCrossRef

15.

Okada K, Frassica FJ, Sim FH, Beabout JW, Bond JR, Unni KK. Parosteal osteosarcoma. A clinicopathological study. J Bone Joint Surg Am 1994; 76: 366–378.PubMed

16.

Sheth DS, Yasko AW, Raymond AE, et al. Conventional and dedifferentiated parosteal osteosarcoma. Diagnosis, treatment, and outcome. Cancer 1996; 78: 2136–2145.PubMedCrossRef

17.

Campanacci M, Picci P, Gherlinzoni F, Guerra A, Bertoni F, Neff JR. Parosteal osteosarcoma. J Bone Joint Surg Br 1984; 66: 313–321.PubMed

18.

Bertoni F, Present D, Hudson T, Enneking WF. The meaning of radiolucencies in parosteal osteosarcoma. J Bone Joint Surg Am 1985; 67: 901–910.PubMed

19.

Futani H, Okayama A, Maruo S, Kinoshita G, Ishikura R. The role of imaging modalities in the diagnosis of primary dedifferentiated parosteal osteosarcoma. J Orthop Sci 2001; 6: 290–294.PubMedCrossRef

20.

Jelinek JS, Murphey MD, Kransdorf MJ, Shmookler BM, Malawer MM, Hur RC. Parosteal osteosarcoma: value of MR imaging and CT in the prediction of histologic grade. Radiology 1996; 201: 837–842.PubMed

21.

Partovi S, Logan PM, Janzen DL, O’Connell JX, Connell DG. Low-grade parosteal osteosarcoma of the ulna with dedifferentiation into high-grade osteosarcoma. Skeletal Radiol 1996; 25: 497–500.PubMedCrossRef

22.

Sciot R, Samson I, Dal Cin P, et al. Giant cell rich parosteal osteosarcoma. Histopathology 1995; 27: 51–55.PubMedCrossRef

Title: Dedifferentiated parosteal osteosarcoma with giant cell tumor component
Authors: Diana M. Cardona
Jacquelyn A. Knapik
John D. Reith
Publication date: 01-04-2008
Publisher: Springer-Verlag
Published in: Skeletal Radiology / Issue 4/2008
Print ISSN: 0364-2348
Electronic ISSN: 1432-2161
DOI: https://doi.org/10.1007/s00256-007-0440-1

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Dedifferentiated parosteal osteosarcoma with giant cell tumor component

Abstract

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Abstract

Please log in to get access to this content

Other articles of this Issue 4/2008

Callus patterns in femur lengthening using a monolateral external fixator

Society of Skeletal Radiology 2008 Annual Meeting, Scientific Presentation Sessions, 9–12 March 2008, La Quinta Resort and Club, La Quinta, CA, USA

Distinguishing benign notochordal cell tumors from vertebral chordoma

Automated bony region identification using artificial neural networks: reliability and validation measurements

Angioleiomyoma in the palm of an 11-year-old boy

BROWSER’S NOTES